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[Genetic basis for skeletal disease. Genetic factors of osteoarthritis with particular reference to skeletal dysplasia].
Clin Calcium. 2010 Aug; 20(8):1166-73.CC

Abstract

Osteoarthritis (OA) is a degenerative disease of articular cartilage. Etiologically, it is classified as primary (idiopathic) and secondary forms. Primary OA is a polygenic disease based on genetic and environmental factors. Identification of its genetic factor, i.e., the susceptibility genes is rapidly in progress. Skeletal dysplasia, inherent failure of formation and/or development of the skeleton, is the frequent cause of secondary OA. Many diseases that belong to skeletal dysplasia, in particular, those which have epiphyseal dysplasia frequently associate OA. Recently, identification of disease genes for skeletal dysplasias is also rapidly in progress. In this paper, I review recent advance in the study of OA susceptibility genes with focus on the relation to disease genes for skeletal dysplasia.

Authors+Show Affiliations

Laboratory for Bone and Joint Diseases, Center for Genomic Medicine, RIKEN/Japanese Skeletal Dysplasia Consortium.

Pub Type(s)

English Abstract
Journal Article
Review

Language

jpn

PubMed ID

20675926

Citation

Ikegawa, Shiro. "[Genetic Basis for Skeletal Disease. Genetic Factors of Osteoarthritis With Particular Reference to Skeletal Dysplasia]." Clinical Calcium, vol. 20, no. 8, 2010, pp. 1166-73.
Ikegawa S. [Genetic basis for skeletal disease. Genetic factors of osteoarthritis with particular reference to skeletal dysplasia]. Clin Calcium. 2010;20(8):1166-73.
Ikegawa, S. (2010). [Genetic basis for skeletal disease. Genetic factors of osteoarthritis with particular reference to skeletal dysplasia]. Clinical Calcium, 20(8), 1166-73. https://doi.org/CliCa100811661173
Ikegawa S. [Genetic Basis for Skeletal Disease. Genetic Factors of Osteoarthritis With Particular Reference to Skeletal Dysplasia]. Clin Calcium. 2010;20(8):1166-73. PubMed PMID: 20675926.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Genetic basis for skeletal disease. Genetic factors of osteoarthritis with particular reference to skeletal dysplasia]. A1 - Ikegawa,Shiro, PY - 2010/8/3/entrez PY - 2010/8/3/pubmed PY - 2010/10/22/medline SP - 1166 EP - 73 JF - Clinical calcium JO - Clin Calcium VL - 20 IS - 8 N2 - Osteoarthritis (OA) is a degenerative disease of articular cartilage. Etiologically, it is classified as primary (idiopathic) and secondary forms. Primary OA is a polygenic disease based on genetic and environmental factors. Identification of its genetic factor, i.e., the susceptibility genes is rapidly in progress. Skeletal dysplasia, inherent failure of formation and/or development of the skeleton, is the frequent cause of secondary OA. Many diseases that belong to skeletal dysplasia, in particular, those which have epiphyseal dysplasia frequently associate OA. Recently, identification of disease genes for skeletal dysplasias is also rapidly in progress. In this paper, I review recent advance in the study of OA susceptibility genes with focus on the relation to disease genes for skeletal dysplasia. SN - 0917-5857 UR - https://www.unboundmedicine.com/medline/citation/20675926/[Genetic_basis_for_skeletal_disease__Genetic_factors_of_osteoarthritis_with_particular_reference_to_skeletal_dysplasia]_ L2 - https://medlineplus.gov/osteoarthritis.html DB - PRIME DP - Unbound Medicine ER -