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[Brazilian lyme-like disease or Baggio-Yoshinari syndrome: exotic and emerging Brazilian tick-borne zoonosis].

Abstract

Lyme disease (LD) is a frequent zoonosis found in the Northern Hemisphere and is considered an infectious disease caused by spirochetes belonging sensu lato to the Borrelia burgdorferi complex transmitted by ticks of the Ixodes ricinus group. In 1992, first cases similar to LD were described in Brazil, when brothers, after a tick bite episode developed symptoms , as erythema migrans, general flu-like symptoms and arthritis. Careful analysis of Brazilian LD-like illness casuistry showed that epidemiological, clinical and laboratorial features in the country were very different from those exhibited by North American and Eurasian LD patients. Human blood-suckers Ixodes ricinus complex ticks were absent at risk areas; the disease is recurrent in the country; Borrelia burgdorferi was never isolated in Brazil and specific serologic tests have shown little positivity with inconsistent results. Furthermore, peripheral blood analysis of patients on electron microscopy exhibited structures resembling Mycoplasma spp, Chlamydia spp and spirochete-like microorganisms. In fact, they were assumed to be latent forms of spirochetes (L form or cell wall deficient bacteria) adapted to survive at inhospitable conditions in vertebrate and invertebrate hosts. For these reasons, the Brazilian zoonosis was named Baggio-Yoshinari Syndrome (BYS) and defined as: "Exotic and emerging Brazilian infectious disease, transmitted by ticks not belonging to the Ixodes ricinus complex, caused by latent spirochetes with atypical morphology, which originates LD-like symptoms, except for occurrence of relapsing episodes and auto-immune disorders".

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  • Authors+Show Affiliations

    ,

    Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP. yoshinari@lim17.fm.usp.br

    , , ,

    Source

    MeSH

    Animals
    Borrelia burgdorferi
    Brazil
    Communicable Diseases, Emerging
    Humans
    Lyme Disease
    Syndrome
    Tick-Borne Diseases

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng por

    PubMed ID

    20676548

    Citation

    TY - JOUR T1 - [Brazilian lyme-like disease or Baggio-Yoshinari syndrome: exotic and emerging Brazilian tick-borne zoonosis]. AU - Yoshinari,Natalino Hajime, AU - Mantovani,Elenice, AU - Bonoldi,Virgínia Lucia Nazario, AU - Marangoni,Roberta Gonçalves, AU - Gauditano,Giancarla, PY - 2009/09/30/received PY - 2010/03/11/accepted PY - 2010/8/3/entrez PY - 2010/8/3/pubmed PY - 2011/8/30/medline SP - 363 EP - 9 JF - Revista da Associacao Medica Brasileira (1992) JO - Rev Assoc Med Bras (1992) VL - 56 IS - 3 N2 - Lyme disease (LD) is a frequent zoonosis found in the Northern Hemisphere and is considered an infectious disease caused by spirochetes belonging sensu lato to the Borrelia burgdorferi complex transmitted by ticks of the Ixodes ricinus group. In 1992, first cases similar to LD were described in Brazil, when brothers, after a tick bite episode developed symptoms , as erythema migrans, general flu-like symptoms and arthritis. Careful analysis of Brazilian LD-like illness casuistry showed that epidemiological, clinical and laboratorial features in the country were very different from those exhibited by North American and Eurasian LD patients. Human blood-suckers Ixodes ricinus complex ticks were absent at risk areas; the disease is recurrent in the country; Borrelia burgdorferi was never isolated in Brazil and specific serologic tests have shown little positivity with inconsistent results. Furthermore, peripheral blood analysis of patients on electron microscopy exhibited structures resembling Mycoplasma spp, Chlamydia spp and spirochete-like microorganisms. In fact, they were assumed to be latent forms of spirochetes (L form or cell wall deficient bacteria) adapted to survive at inhospitable conditions in vertebrate and invertebrate hosts. For these reasons, the Brazilian zoonosis was named Baggio-Yoshinari Syndrome (BYS) and defined as: "Exotic and emerging Brazilian infectious disease, transmitted by ticks not belonging to the Ixodes ricinus complex, caused by latent spirochetes with atypical morphology, which originates LD-like symptoms, except for occurrence of relapsing episodes and auto-immune disorders". SN - 1806-9282 UR - https://www.unboundmedicine.com/medline/citation/20676548/full_citation/[Brazilian_lyme_like_disease_or_baggio_yoshinari_syndrome:_exotic_and_emerging_brazilian_tick_borne_zoonosis_] L2 - http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302010000300025&lng=en&nrm=iso&tlng=en ER -