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Enantioselective construction of spiroindolenines by Ir-catalyzed allylic alkylation reactions.
J Am Chem Soc. 2010 Aug 25; 132(33):11418-9.JA

Abstract

With 2-methyl-1,2,3,4-tetrahydroquinoline-derived phosphoramidite ligand (R,R(a))-L(6), Ir-catalyzed intramolecular C-3 allylic alkylation of indoles has been realized to afford highly enantioenriched spiroindolenine derivatives in 92-98% yields with up to >99/1 dr and 97% ee.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Wu QF
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China.
He H
No affiliation info available
Liu WB
No affiliation info available
You SL
No affiliation info available

MeSH

AlkylationAllyl CompoundsCatalysisIndolesIridiumMolecular StructureSpiro CompoundsStereoisomerism

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20677752

Citation

Wu, Qing-Feng, et al. "Enantioselective Construction of Spiroindolenines By Ir-catalyzed Allylic Alkylation Reactions." Journal of the American Chemical Society, vol. 132, no. 33, 2010, pp. 11418-9.
Wu QF, He H, Liu WB, et al. Enantioselective construction of spiroindolenines by Ir-catalyzed allylic alkylation reactions. J Am Chem Soc. 2010;132(33):11418-9.
Wu, Q. F., He, H., Liu, W. B., & You, S. L. (2010). Enantioselective construction of spiroindolenines by Ir-catalyzed allylic alkylation reactions. Journal of the American Chemical Society, 132(33), 11418-9. https://doi.org/10.1021/ja105111n
Wu QF, et al. Enantioselective Construction of Spiroindolenines By Ir-catalyzed Allylic Alkylation Reactions. J Am Chem Soc. 2010 Aug 25;132(33):11418-9. PubMed PMID: 20677752.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Enantioselective construction of spiroindolenines by Ir-catalyzed allylic alkylation reactions. AU - Wu,Qing-Feng, AU - He,Hu, AU - Liu,Wen-Bo, AU - You,Shu-Li, PY - 2010/8/4/entrez PY - 2010/8/4/pubmed PY - 2010/12/14/medline SP - 11418 EP - 9 JF - Journal of the American Chemical Society JO - J Am Chem Soc VL - 132 IS - 33 N2 - With 2-methyl-1,2,3,4-tetrahydroquinoline-derived phosphoramidite ligand (R,R(a))-L(6), Ir-catalyzed intramolecular C-3 allylic alkylation of indoles has been realized to afford highly enantioenriched spiroindolenine derivatives in 92-98% yields with up to >99/1 dr and 97% ee. SN - 1520-5126 UR - https://www.unboundmedicine.com/medline/citation/20677752/Enantioselective_construction_of_spiroindolenines_by_Ir_catalyzed_allylic_alkylation_reactions_ L2 - https://doi.org/10.1021/ja105111n DB - PRIME DP - Unbound Medicine ER -