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Neuroprotective xanthone glycosides from Swertia punicea.
J Nat Prod. 2010 Aug 27; 73(8):1422-6.JN

Abstract

Two new dimeric xanthone O-glycosides, puniceasides A (1) and B (2), a new trimeric O-glycoside, puniceaside C (3), and two new trimeric C-glycosides, puniceasides D (4) and E (5), together with 12 known xanthones were isolated from the entire plant of Swertia punicea. The structures of 1-5 were determined by HRESIMS and NMR spectroscopic methods. Compounds 2, 6, and 7 exhibited potent neuroprotective activity against H(2)O(2)-induced PC12 cell damage.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Du XG
The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, People's Republic of China.
Wang W
No affiliation info available
Zhang SP
No affiliation info available
Pu XP
No affiliation info available
Zhang QY
No affiliation info available
Ye M
No affiliation info available
Zhao YY
No affiliation info available
Wang BR
No affiliation info available
Khan IA
No affiliation info available
Guo DA
No affiliation info available

MeSH

AnimalsDrugs, Chinese HerbalGlycosidesHydrogen PeroxideMolecular StructureNeuroprotective AgentsNuclear Magnetic Resonance, BiomolecularPC12 CellsRatsSwertiaXanthones

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20677781

Citation

Du, Xin-Gang, et al. "Neuroprotective Xanthone Glycosides From Swertia Punicea." Journal of Natural Products, vol. 73, no. 8, 2010, pp. 1422-6.
Du XG, Wang W, Zhang SP, et al. Neuroprotective xanthone glycosides from Swertia punicea. J Nat Prod. 2010;73(8):1422-6.
Du, X. G., Wang, W., Zhang, S. P., Pu, X. P., Zhang, Q. Y., Ye, M., Zhao, Y. Y., Wang, B. R., Khan, I. A., & Guo, D. A. (2010). Neuroprotective xanthone glycosides from Swertia punicea. Journal of Natural Products, 73(8), 1422-6. https://doi.org/10.1021/np100008r
Du XG, et al. Neuroprotective Xanthone Glycosides From Swertia Punicea. J Nat Prod. 2010 Aug 27;73(8):1422-6. PubMed PMID: 20677781.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuroprotective xanthone glycosides from Swertia punicea. AU - Du,Xin-Gang, AU - Wang,Wei, AU - Zhang,Shi-Ping, AU - Pu,Xiao-Ping, AU - Zhang,Qing-Ying, AU - Ye,Min, AU - Zhao,Yu-Ying, AU - Wang,Bao-Rong, AU - Khan,Ikhlas A, AU - Guo,De-An, PY - 2010/8/4/entrez PY - 2010/8/4/pubmed PY - 2010/9/23/medline SP - 1422 EP - 6 JF - Journal of natural products JO - J Nat Prod VL - 73 IS - 8 N2 - Two new dimeric xanthone O-glycosides, puniceasides A (1) and B (2), a new trimeric O-glycoside, puniceaside C (3), and two new trimeric C-glycosides, puniceasides D (4) and E (5), together with 12 known xanthones were isolated from the entire plant of Swertia punicea. The structures of 1-5 were determined by HRESIMS and NMR spectroscopic methods. Compounds 2, 6, and 7 exhibited potent neuroprotective activity against H(2)O(2)-induced PC12 cell damage. SN - 1520-6025 UR - https://www.unboundmedicine.com/medline/citation/20677781/Neuroprotective_xanthone_glycosides_from_Swertia_punicea_ DB - PRIME DP - Unbound Medicine ER -