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Cognition in transmembrane domain neuregulin 1 mutant mice.
Neuroscience. 2010 Oct 27; 170(3):800-7.N

Abstract

Neuregulin 1 (NRG1), which has been implicated in the development of schizophrenia, is expressed widely throughout the brain and influences key neurodevelopmental processes such as myelination and neuronal migration. The heterozygous transmembrane domain Nrg1 mutant mouse (Nrg1 TM HET) exhibits a neurobehavioural phenotype relevant for schizophrenia research, characterized by the development of locomotor hyperactivity, social withdrawal, increased sensitivity to environmental manipulation, and changes to the serotonergic system. As only limited data are available on the learning and memory performance of Nrg1 TM HET mice, we conducted a comprehensive examination of these mice and their wild type-like littermates in a variety of paradigms, including fear conditioning (FC), radial arm maze (RAM), Y maze, object exploration and passive avoidance (PA). Male neuregulin 1 hypomorphic mice displayed impairments in the novel object recognition and FC tasks, including reduced interest in the novel object and reduced FC to a context, but not a discrete cue. These cognitive deficits were task-specific, as no differences were seen between mutant and control mice in spatial learning (i.e. RAM and Y maze) for both working and reference memory measures, or in the PA paradigm. These findings indicate that neuregulin 1 plays a moderate role in cognition and present further behavioural validation of this genetic mouse model for the schizophrenia candidate gene neuregulin 1.

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Authors+Show Affiliations

Duffy L
Schizophrenia Research Institute, Sydney, NSW 2010, Australia.
Cappas E
No affiliation info available
Lai D
No affiliation info available
Boucher AA
No affiliation info available
Karl T
No affiliation info available

MeSH

AnimalsBehavior, AnimalCognitionDisease Models, AnimalHeterozygoteMaleMiceMice, Inbred C57BLMice, Mutant StrainsNeuregulin-1PhenotypeSchizophrenia

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20678553

Citation

Duffy, L, et al. "Cognition in Transmembrane Domain Neuregulin 1 Mutant Mice." Neuroscience, vol. 170, no. 3, 2010, pp. 800-7.
Duffy L, Cappas E, Lai D, et al. Cognition in transmembrane domain neuregulin 1 mutant mice. Neuroscience. 2010;170(3):800-7.
Duffy, L., Cappas, E., Lai, D., Boucher, A. A., & Karl, T. (2010). Cognition in transmembrane domain neuregulin 1 mutant mice. Neuroscience, 170(3), 800-7. https://doi.org/10.1016/j.neuroscience.2010.07.042
Duffy L, et al. Cognition in Transmembrane Domain Neuregulin 1 Mutant Mice. Neuroscience. 2010 Oct 27;170(3):800-7. PubMed PMID: 20678553.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cognition in transmembrane domain neuregulin 1 mutant mice. AU - Duffy,L, AU - Cappas,E, AU - Lai,D, AU - Boucher,A A, AU - Karl,T, Y1 - 2010/08/01/ PY - 2010/03/23/received PY - 2010/07/02/revised PY - 2010/07/21/accepted PY - 2010/8/4/entrez PY - 2010/8/4/pubmed PY - 2011/1/12/medline SP - 800 EP - 7 JF - Neuroscience JO - Neuroscience VL - 170 IS - 3 N2 - Neuregulin 1 (NRG1), which has been implicated in the development of schizophrenia, is expressed widely throughout the brain and influences key neurodevelopmental processes such as myelination and neuronal migration. The heterozygous transmembrane domain Nrg1 mutant mouse (Nrg1 TM HET) exhibits a neurobehavioural phenotype relevant for schizophrenia research, characterized by the development of locomotor hyperactivity, social withdrawal, increased sensitivity to environmental manipulation, and changes to the serotonergic system. As only limited data are available on the learning and memory performance of Nrg1 TM HET mice, we conducted a comprehensive examination of these mice and their wild type-like littermates in a variety of paradigms, including fear conditioning (FC), radial arm maze (RAM), Y maze, object exploration and passive avoidance (PA). Male neuregulin 1 hypomorphic mice displayed impairments in the novel object recognition and FC tasks, including reduced interest in the novel object and reduced FC to a context, but not a discrete cue. These cognitive deficits were task-specific, as no differences were seen between mutant and control mice in spatial learning (i.e. RAM and Y maze) for both working and reference memory measures, or in the PA paradigm. These findings indicate that neuregulin 1 plays a moderate role in cognition and present further behavioural validation of this genetic mouse model for the schizophrenia candidate gene neuregulin 1. SN - 1873-7544 UR - https://www.unboundmedicine.com/medline/citation/20678553/Cognition_in_transmembrane_domain_neuregulin_1_mutant_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-4522(10)01045-6 DB - PRIME DP - Unbound Medicine ER -