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Sustained release coating of tablets with Eudragit(®) RS/RL using a novel electrostatic dry powder coating process.
Int J Pharm. 2010 Oct 31; 399(1-2):37-43.IJ

Abstract

The objectives of this study were to develop an electrostatic dry powder coating process for sustained coating tablets with Eudragit(®) RS/RL and to investigate the effects of various factors and operating conditions on the coating process and drug release profile. A liquid plasticizer (triethyl citrate) was sprayed onto the surface of the tablets followed by spraying coating powder by an electrostatic spray gun. The powder coated tablets were cured at elevated temperature for a film formation. Liquid plasticizer played important roles in lowering down the glass transition temperature (T(g)) of the coating polymer and increasing the surface electrical conduction of tablet cores. Electrostatic assisted coating deposition was confirmed by the fact that higher coating level was obtained with electrical charging than the ones without it. The micrographs of scanning electron microscopy (SEM) of coated tablets showed that the film formation mainly occurred during the curing step. Higher curing temperature and longer curing time help enhance the film formation. The in vitro drug release profiles indicated that curing time, temperature, coating level and ratio of Eudragit(®) RS/RL were the main factors affecting the sustained release profile. The electrostatic dry powder coating process has been demonstrated to be an alternative for tablet sustained release coating with Eudragit(®) RS and RL.

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Authors+Show Affiliations

Qiao M
Department of Chemical and Biochemical Engineering, University of Western Ontario, London, Ontario, Canada.
Luo Y
No affiliation info available
Zhang L
No affiliation info available
Ma Y
No affiliation info available
Stephenson TS
No affiliation info available
Zhu J
No affiliation info available

MeSH

Acrylic ResinsCalorimetry, Differential ScanningDrug CompoundingHot TemperatureIbuprofenMicroscopy, Electron, ScanningParticle SizePhase TransitionPolymersPowdersSolubilityStatic ElectricitySurface PropertiesTablets, Enteric-Coated

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20678560

Citation

Qiao, Mingxi, et al. "Sustained Release Coating of Tablets With Eudragit(®) RS/RL Using a Novel Electrostatic Dry Powder Coating Process." International Journal of Pharmaceutics, vol. 399, no. 1-2, 2010, pp. 37-43.
Qiao M, Luo Y, Zhang L, et al. Sustained release coating of tablets with Eudragit(®) RS/RL using a novel electrostatic dry powder coating process. Int J Pharm. 2010;399(1-2):37-43.
Qiao, M., Luo, Y., Zhang, L., Ma, Y., Stephenson, T. S., & Zhu, J. (2010). Sustained release coating of tablets with Eudragit(®) RS/RL using a novel electrostatic dry powder coating process. International Journal of Pharmaceutics, 399(1-2), 37-43. https://doi.org/10.1016/j.ijpharm.2010.07.047
Qiao M, et al. Sustained Release Coating of Tablets With Eudragit(®) RS/RL Using a Novel Electrostatic Dry Powder Coating Process. Int J Pharm. 2010 Oct 31;399(1-2):37-43. PubMed PMID: 20678560.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sustained release coating of tablets with Eudragit(®) RS/RL using a novel electrostatic dry powder coating process. AU - Qiao,Mingxi, AU - Luo,Yanfeng, AU - Zhang,Liqiang, AU - Ma,Yingliang, AU - Stephenson,Tyler Shawn, AU - Zhu,Jesse, Y1 - 2010/08/01/ PY - 2010/05/09/received PY - 2010/07/19/revised PY - 2010/07/26/accepted PY - 2010/8/4/entrez PY - 2010/8/4/pubmed PY - 2011/2/5/medline SP - 37 EP - 43 JF - International journal of pharmaceutics JO - Int J Pharm VL - 399 IS - 1-2 N2 - The objectives of this study were to develop an electrostatic dry powder coating process for sustained coating tablets with Eudragit(®) RS/RL and to investigate the effects of various factors and operating conditions on the coating process and drug release profile. A liquid plasticizer (triethyl citrate) was sprayed onto the surface of the tablets followed by spraying coating powder by an electrostatic spray gun. The powder coated tablets were cured at elevated temperature for a film formation. Liquid plasticizer played important roles in lowering down the glass transition temperature (T(g)) of the coating polymer and increasing the surface electrical conduction of tablet cores. Electrostatic assisted coating deposition was confirmed by the fact that higher coating level was obtained with electrical charging than the ones without it. The micrographs of scanning electron microscopy (SEM) of coated tablets showed that the film formation mainly occurred during the curing step. Higher curing temperature and longer curing time help enhance the film formation. The in vitro drug release profiles indicated that curing time, temperature, coating level and ratio of Eudragit(®) RS/RL were the main factors affecting the sustained release profile. The electrostatic dry powder coating process has been demonstrated to be an alternative for tablet sustained release coating with Eudragit(®) RS and RL. SN - 1873-3476 UR - https://www.unboundmedicine.com/medline/citation/20678560/Sustained_release_coating_of_tablets_with_Eudragit_®__RS/RL_using_a_novel_electrostatic_dry_powder_coating_process_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5173(10)00574-0 DB - PRIME DP - Unbound Medicine ER -