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Tianeptine reduces morphine antinociceptive tolerance and physical dependence.
Behav Pharmacol. 2010 Sep; 21(5-6):523-9.BP

Abstract

Long-term use of morphine can cause neuronal dystrophic changes in specific areas of the brain. These changes may underlie the mechanism for developing morphine antinociceptive tolerance and physical dependence. We evaluated the effect of tianeptine, an antidepressant with prominent neuroprotective and neuroplastic properties, on the development of morphine antinociceptive tolerance and physical dependence. Male C57BL/6 mice were rendered tolerant to or dependent on morphine by subcutaneously injecting them with morphine (10 mg/kg) and intraperitoneally with saline or tianeptine (1, 3, or 5 mg/kg) twice daily for 6 days. The mice were given a daily tail-flick test 1 h after the first morphine injection to evaluate the development of their tolerance to morphine antinociception. To evaluate their physical dependence on morphine, 3 h after the final morphine injection on day 6, naloxone-HCl-precipitated (2 mg/kg, intraperitoneally) withdrawal symptoms were counted for 30 min, and body weight was checked 1 h after the naloxone injection. Tianeptine per se produced no antinociception, neither did it modify the antinociception produced by morphine, nor did it evoke the behavioral responses different from those in the saline controls. The combination of tianeptine with morphine significantly reduced the development of morphine antinociceptive tolerance and suppressed the incidence of naloxone-precipitated withdrawal symptoms. We conclude that tianeptine is an effective inhibitor of morphine-induced antinociceptive tolerance and physical dependence in mice. Our results would imply that comedication with tianeptine and morphine might benefit those who need long-term morphine treatment.

Authors+Show Affiliations

Department of Anesthesiology, Chia Nan University of Pharmacy and Science, Tainan, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20679893

Citation

Chu, Chin-Chen, et al. "Tianeptine Reduces Morphine Antinociceptive Tolerance and Physical Dependence." Behavioural Pharmacology, vol. 21, no. 5-6, 2010, pp. 523-9.
Chu CC, Shieh JP, Shui HA, et al. Tianeptine reduces morphine antinociceptive tolerance and physical dependence. Behav Pharmacol. 2010;21(5-6):523-9.
Chu, C. C., Shieh, J. P., Shui, H. A., Chen, J. Y., Hsing, C. H., Tzeng, J. I., Wang, J. J., & Ho, S. T. (2010). Tianeptine reduces morphine antinociceptive tolerance and physical dependence. Behavioural Pharmacology, 21(5-6), 523-9. https://doi.org/10.1097/FBP.0b013e32833db7d4
Chu CC, et al. Tianeptine Reduces Morphine Antinociceptive Tolerance and Physical Dependence. Behav Pharmacol. 2010;21(5-6):523-9. PubMed PMID: 20679893.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tianeptine reduces morphine antinociceptive tolerance and physical dependence. AU - Chu,Chin-Chen, AU - Shieh,Ja-Ping, AU - Shui,Hao-Ai, AU - Chen,Jen-Yin, AU - Hsing,Chung-Hsi, AU - Tzeng,Jann-Inn, AU - Wang,Jhi-Joung, AU - Ho,Shung-Tai, PY - 2010/8/4/entrez PY - 2010/8/4/pubmed PY - 2010/12/14/medline SP - 523 EP - 9 JF - Behavioural pharmacology JO - Behav Pharmacol VL - 21 IS - 5-6 N2 - Long-term use of morphine can cause neuronal dystrophic changes in specific areas of the brain. These changes may underlie the mechanism for developing morphine antinociceptive tolerance and physical dependence. We evaluated the effect of tianeptine, an antidepressant with prominent neuroprotective and neuroplastic properties, on the development of morphine antinociceptive tolerance and physical dependence. Male C57BL/6 mice were rendered tolerant to or dependent on morphine by subcutaneously injecting them with morphine (10 mg/kg) and intraperitoneally with saline or tianeptine (1, 3, or 5 mg/kg) twice daily for 6 days. The mice were given a daily tail-flick test 1 h after the first morphine injection to evaluate the development of their tolerance to morphine antinociception. To evaluate their physical dependence on morphine, 3 h after the final morphine injection on day 6, naloxone-HCl-precipitated (2 mg/kg, intraperitoneally) withdrawal symptoms were counted for 30 min, and body weight was checked 1 h after the naloxone injection. Tianeptine per se produced no antinociception, neither did it modify the antinociception produced by morphine, nor did it evoke the behavioral responses different from those in the saline controls. The combination of tianeptine with morphine significantly reduced the development of morphine antinociceptive tolerance and suppressed the incidence of naloxone-precipitated withdrawal symptoms. We conclude that tianeptine is an effective inhibitor of morphine-induced antinociceptive tolerance and physical dependence in mice. Our results would imply that comedication with tianeptine and morphine might benefit those who need long-term morphine treatment. SN - 1473-5849 UR - https://www.unboundmedicine.com/medline/citation/20679893/Tianeptine_reduces_morphine_antinociceptive_tolerance_and_physical_dependence_ L2 - https://doi.org/10.1097/FBP.0b013e32833db7d4 DB - PRIME DP - Unbound Medicine ER -