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Electroanalytical characteristics of antipsychotic drug ziprasidone and its determination in pharmaceuticals and serum samples on solid electrodes.
Talanta. 2010 Jun 30; 82(1):286-95.T

Abstract

Ziprasidone is a psychotropic agent used for the treatment of schizophrenia. Its oxidation was investigated electrochemically at boron-doped diamond and glassy carbon electrodes using cyclic, differential pulse, and square wave voltammetry. The dependence of the peak current and peak potentials on pH, concentration, nature of the buffer, and scan rate were examined. The process was diffusion and adsorption controlled for boron-doped diamond and glassy carbon electrodes, respectively. The possible mechanism of oxidation was discussed with some model compounds that have indole and piperazine oxidations. A linear response was obtained between 8 x 10(-7) and 8 x 10(-5) M for the first peak in acetate buffer (pH 5.5) and between 2 x 10(-6) and 2 x 10(-4) M for the second peak in 0.1 M H(2)SO(4) with boron-doped diamond electrode for differential pulse and square wave voltammetric techniques. The reproducibility and accuracy of the proposed methods were found between 0.31 and 1.20, 99.27 and 100.22, respectively. The recovery studies were also achieved to check selectivity and accuracy of the methods. The proposed methods were applied for the determination of ziprasidone from pharmaceutical dosage forms and human serum samples without any time-consuming extraction, separation, evaporation or adsorption steps prior to drug assay except precipitation of the proteins using acetonitrile. The results were statistically compared with those obtained through an established LC-UV technique, no significant differences were been found between the voltammetric and LC methods.

Authors+Show Affiliations

Karadeniz Technical University, Faculty of Pharmacy, 61080 Trabzon, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20685469

Citation

Kul, Dilek, et al. "Electroanalytical Characteristics of Antipsychotic Drug Ziprasidone and Its Determination in Pharmaceuticals and Serum Samples On Solid Electrodes." Talanta, vol. 82, no. 1, 2010, pp. 286-95.
Kul D, Gumustas M, Uslu B, et al. Electroanalytical characteristics of antipsychotic drug ziprasidone and its determination in pharmaceuticals and serum samples on solid electrodes. Talanta. 2010;82(1):286-95.
Kul, D., Gumustas, M., Uslu, B., & Ozkan, S. A. (2010). Electroanalytical characteristics of antipsychotic drug ziprasidone and its determination in pharmaceuticals and serum samples on solid electrodes. Talanta, 82(1), 286-95. https://doi.org/10.1016/j.talanta.2010.04.036
Kul D, et al. Electroanalytical Characteristics of Antipsychotic Drug Ziprasidone and Its Determination in Pharmaceuticals and Serum Samples On Solid Electrodes. Talanta. 2010 Jun 30;82(1):286-95. PubMed PMID: 20685469.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Electroanalytical characteristics of antipsychotic drug ziprasidone and its determination in pharmaceuticals and serum samples on solid electrodes. AU - Kul,Dilek, AU - Gumustas,Mehmet, AU - Uslu,Bengi, AU - Ozkan,Sibel A, Y1 - 2010/04/22/ PY - 2010/01/27/received PY - 2010/04/09/revised PY - 2010/04/16/accepted PY - 2010/8/6/entrez PY - 2010/8/6/pubmed PY - 2011/1/5/medline SP - 286 EP - 95 JF - Talanta JO - Talanta VL - 82 IS - 1 N2 - Ziprasidone is a psychotropic agent used for the treatment of schizophrenia. Its oxidation was investigated electrochemically at boron-doped diamond and glassy carbon electrodes using cyclic, differential pulse, and square wave voltammetry. The dependence of the peak current and peak potentials on pH, concentration, nature of the buffer, and scan rate were examined. The process was diffusion and adsorption controlled for boron-doped diamond and glassy carbon electrodes, respectively. The possible mechanism of oxidation was discussed with some model compounds that have indole and piperazine oxidations. A linear response was obtained between 8 x 10(-7) and 8 x 10(-5) M for the first peak in acetate buffer (pH 5.5) and between 2 x 10(-6) and 2 x 10(-4) M for the second peak in 0.1 M H(2)SO(4) with boron-doped diamond electrode for differential pulse and square wave voltammetric techniques. The reproducibility and accuracy of the proposed methods were found between 0.31 and 1.20, 99.27 and 100.22, respectively. The recovery studies were also achieved to check selectivity and accuracy of the methods. The proposed methods were applied for the determination of ziprasidone from pharmaceutical dosage forms and human serum samples without any time-consuming extraction, separation, evaporation or adsorption steps prior to drug assay except precipitation of the proteins using acetonitrile. The results were statistically compared with those obtained through an established LC-UV technique, no significant differences were been found between the voltammetric and LC methods. SN - 1873-3573 UR - https://www.unboundmedicine.com/medline/citation/20685469/Electroanalytical_characteristics_of_antipsychotic_drug_ziprasidone_and_its_determination_in_pharmaceuticals_and_serum_samples_on_solid_electrodes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0039-9140(10)00293-6 DB - PRIME DP - Unbound Medicine ER -