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Effect of increased consumption of whole-grain foods on blood pressure and other cardiovascular risk markers in healthy middle-aged persons: a randomized controlled trial.

Abstract

BACKGROUND

Three daily portions of whole-grain foods could lower cardiovascular disease risk, but a comprehensive intervention trial was needed to confirm this recommendation.

OBJECTIVES

We aimed to assess the effects of consumption of 3 daily portions of whole-grain foods (provided as only wheat or a mixture of wheat and oats) on markers of cardiovascular disease risk in relatively high-risk individuals.

DESIGN

This was a randomized controlled dietary trial in middle-aged healthy individuals. After a 4-wk run-in period with a refined diet, we randomly allocated volunteers to a control (refined diet), wheat, or wheat + oats group for 12 wk. The primary outcome was a reduction of cardiovascular disease risk factors by dietary intervention with whole grains, which included lipid and inflammatory marker concentrations, insulin sensitivity, and blood pressure.

RESULTS

We recruited a total of 233 volunteers; 24 volunteers withdrew, and 3 volunteers were excluded. Systolic blood pressure and pulse pressure were significantly reduced by 6 and 3 mm Hg, respectively, in the whole-grain foods groups compared with the control group. Systemic markers of cardiovascular disease risk remained unchanged apart from cholesterol concentrations, which decreased slightly but significantly in the refined group.

CONCLUSIONS

Daily consumption of 3 portions of whole-grain foods can significantly reduce cardiovascular disease risk in middle-aged people mainly through blood pressure-lowering mechanisms. The observed decrease in systolic blood pressure could decrease the incidence of coronary artery disease and stroke by ≥15% and 25%, respectively. This trial was registered at clinicaltrials.gov as ISRCTN27657880.

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  • Authors+Show Affiliations

    ,

    Division of Applied Medicine, University of Aberdeen, Aberdeen, United Kingdom. f.thies@abdn.ac.uk

    , , , , , , , ,

    Source

    MeSH

    Adult
    Aged
    Avena
    Blood Pressure
    Cardiovascular Diseases
    Dietary Carbohydrates
    Dietary Fats
    Edible Grain
    Female
    Humans
    Inflammation
    Lipids
    Male
    Middle Aged
    Polysaccharides
    Reference Values
    Single-Blind Method
    Triticum

    Pub Type(s)

    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    20685951

    Citation

    Tighe, Paula, et al. "Effect of Increased Consumption of Whole-grain Foods On Blood Pressure and Other Cardiovascular Risk Markers in Healthy Middle-aged Persons: a Randomized Controlled Trial." The American Journal of Clinical Nutrition, vol. 92, no. 4, 2010, pp. 733-40.
    Tighe P, Duthie G, Vaughan N, et al. Effect of increased consumption of whole-grain foods on blood pressure and other cardiovascular risk markers in healthy middle-aged persons: a randomized controlled trial. Am J Clin Nutr. 2010;92(4):733-40.
    Tighe, P., Duthie, G., Vaughan, N., Brittenden, J., Simpson, W. G., Duthie, S., ... Thies, F. (2010). Effect of increased consumption of whole-grain foods on blood pressure and other cardiovascular risk markers in healthy middle-aged persons: a randomized controlled trial. The American Journal of Clinical Nutrition, 92(4), pp. 733-40. doi:10.3945/ajcn.2010.29417.
    Tighe P, et al. Effect of Increased Consumption of Whole-grain Foods On Blood Pressure and Other Cardiovascular Risk Markers in Healthy Middle-aged Persons: a Randomized Controlled Trial. Am J Clin Nutr. 2010;92(4):733-40. PubMed PMID: 20685951.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effect of increased consumption of whole-grain foods on blood pressure and other cardiovascular risk markers in healthy middle-aged persons: a randomized controlled trial. AU - Tighe,Paula, AU - Duthie,Garry, AU - Vaughan,Nicholas, AU - Brittenden,Julie, AU - Simpson,William G, AU - Duthie,Susan, AU - Mutch,William, AU - Wahle,Klaus, AU - Horgan,Graham, AU - Thies,Frank, Y1 - 2010/08/04/ PY - 2010/8/6/entrez PY - 2010/8/6/pubmed PY - 2010/10/28/medline SP - 733 EP - 40 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 92 IS - 4 N2 - BACKGROUND: Three daily portions of whole-grain foods could lower cardiovascular disease risk, but a comprehensive intervention trial was needed to confirm this recommendation. OBJECTIVES: We aimed to assess the effects of consumption of 3 daily portions of whole-grain foods (provided as only wheat or a mixture of wheat and oats) on markers of cardiovascular disease risk in relatively high-risk individuals. DESIGN: This was a randomized controlled dietary trial in middle-aged healthy individuals. After a 4-wk run-in period with a refined diet, we randomly allocated volunteers to a control (refined diet), wheat, or wheat + oats group for 12 wk. The primary outcome was a reduction of cardiovascular disease risk factors by dietary intervention with whole grains, which included lipid and inflammatory marker concentrations, insulin sensitivity, and blood pressure. RESULTS: We recruited a total of 233 volunteers; 24 volunteers withdrew, and 3 volunteers were excluded. Systolic blood pressure and pulse pressure were significantly reduced by 6 and 3 mm Hg, respectively, in the whole-grain foods groups compared with the control group. Systemic markers of cardiovascular disease risk remained unchanged apart from cholesterol concentrations, which decreased slightly but significantly in the refined group. CONCLUSIONS: Daily consumption of 3 portions of whole-grain foods can significantly reduce cardiovascular disease risk in middle-aged people mainly through blood pressure-lowering mechanisms. The observed decrease in systolic blood pressure could decrease the incidence of coronary artery disease and stroke by ≥15% and 25%, respectively. This trial was registered at clinicaltrials.gov as ISRCTN27657880. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/20685951/full_citation L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.2010.29417 DB - PRIME DP - Unbound Medicine ER -