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Chemoprevention of prostate cancer with lycopene in the TRAMP model.
Prostate. 2010 Oct 01; 70(14):1547-54.P

Abstract

BACKGROUND

Dietary lycopene combined with other constituents from whole tomatoes was previously found to have greater chemopreventive effects against prostate cancer as compared to pure lycopene provided in a beadlet formulation. We hypothesized that tomato paste would have greater chemopreventive effects in transgenic adenocarcinoma of the mouse prostate (TRAMP) mice relative to equivalent lycopene doses provided from lycopene beadlets.

METHODS

Fifty-nine TRAMP mice were randomized to a control diet or to diets providing 28 mg lycopene per kg diet from tomato paste (TP) or from lycopene beadlet (LB), and sacrificed at 20 weeks. Prostate histopathology, prostate weight and serum levels of IGF-I and IGF binding protein-3 were evaluated.

RESULTS

The incidence of prostate cancer was significantly decreased in the LB group relative to the control group (60% vs. 95%, respectively, P = 0.0197) whereas the difference between the TP and control groups was not statistically significant (80% vs. 95%, P = 0.34). There was no difference in prostate weights between the groups. Total lycopene levels in the serum and prostate tissue were similarly elevated in the LB and TP groups relative to the control group. The ratio of 5-cis-lycopene to trans-lycopene in the serum was significantly greater in the LB group relative to the TP group (P = 0.0001). Oxidative DNA damage was significantly reduced in the livers of mice fed LB and TP diets relative to the control group.

CONCLUSIONS

This preclinical trial suggests significant chemopreventive activity with a lycopene beadlet-enriched diet. The chemopreventive effects of lycopene from beadlets versus whole tomato products requires further testing in preclinical and clinical models of prostate cancer.

Authors+Show Affiliations

Department of Urology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20687227

Citation

Konijeti, Ramdev, et al. "Chemoprevention of Prostate Cancer With Lycopene in the TRAMP Model." The Prostate, vol. 70, no. 14, 2010, pp. 1547-54.
Konijeti R, Henning S, Moro A, et al. Chemoprevention of prostate cancer with lycopene in the TRAMP model. Prostate. 2010;70(14):1547-54.
Konijeti, R., Henning, S., Moro, A., Sheikh, A., Elashoff, D., Shapiro, A., Ku, M., Said, J. W., Heber, D., Cohen, P., & Aronson, W. J. (2010). Chemoprevention of prostate cancer with lycopene in the TRAMP model. The Prostate, 70(14), 1547-54. https://doi.org/10.1002/pros.21190
Konijeti R, et al. Chemoprevention of Prostate Cancer With Lycopene in the TRAMP Model. Prostate. 2010 Oct 1;70(14):1547-54. PubMed PMID: 20687227.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chemoprevention of prostate cancer with lycopene in the TRAMP model. AU - Konijeti,Ramdev, AU - Henning,Susanne, AU - Moro,Aune, AU - Sheikh,Ahmed, AU - Elashoff,David, AU - Shapiro,Ari, AU - Ku,Melvin, AU - Said,Jonathan W, AU - Heber,David, AU - Cohen,Pinchas, AU - Aronson,William J, PY - 2010/8/6/entrez PY - 2010/8/6/pubmed PY - 2010/9/24/medline SP - 1547 EP - 54 JF - The Prostate JO - Prostate VL - 70 IS - 14 N2 - BACKGROUND: Dietary lycopene combined with other constituents from whole tomatoes was previously found to have greater chemopreventive effects against prostate cancer as compared to pure lycopene provided in a beadlet formulation. We hypothesized that tomato paste would have greater chemopreventive effects in transgenic adenocarcinoma of the mouse prostate (TRAMP) mice relative to equivalent lycopene doses provided from lycopene beadlets. METHODS: Fifty-nine TRAMP mice were randomized to a control diet or to diets providing 28 mg lycopene per kg diet from tomato paste (TP) or from lycopene beadlet (LB), and sacrificed at 20 weeks. Prostate histopathology, prostate weight and serum levels of IGF-I and IGF binding protein-3 were evaluated. RESULTS: The incidence of prostate cancer was significantly decreased in the LB group relative to the control group (60% vs. 95%, respectively, P = 0.0197) whereas the difference between the TP and control groups was not statistically significant (80% vs. 95%, P = 0.34). There was no difference in prostate weights between the groups. Total lycopene levels in the serum and prostate tissue were similarly elevated in the LB and TP groups relative to the control group. The ratio of 5-cis-lycopene to trans-lycopene in the serum was significantly greater in the LB group relative to the TP group (P = 0.0001). Oxidative DNA damage was significantly reduced in the livers of mice fed LB and TP diets relative to the control group. CONCLUSIONS: This preclinical trial suggests significant chemopreventive activity with a lycopene beadlet-enriched diet. The chemopreventive effects of lycopene from beadlets versus whole tomato products requires further testing in preclinical and clinical models of prostate cancer. SN - 1097-0045 UR - https://www.unboundmedicine.com/medline/citation/20687227/Chemoprevention_of_prostate_cancer_with_lycopene_in_the_TRAMP_model_ L2 - https://doi.org/10.1002/pros.21190 DB - PRIME DP - Unbound Medicine ER -