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Phototoxicity of essential oils intended for cosmetic use.
Toxicol In Vitro 2010; 24(8):2084-9TV

Abstract

The aim of this study, linked-up with a previous study on bergamot oils, was the evaluation of phototoxic potential of essential oils (orange, lemon and Litsea cubeba), used as cosmetic ingredients. The applied tiered testing strategy included chemical analysis of the substances (by means of capillary gas chromatography/mass spectrometry), in vitro 3T3 NRU phototoxicity test and EpiDerm™ skin phototoxicity test. In order to clarify the situation in man, the highest non-phototoxic/non-cytotoxic concentrations and concentrations 10 x lower (safety factor 10) were tested xin vivo by means of human skin photopatch test in a limited group of human volunteers. The study revealed, that phototoxicity of the essential oils was dependent on the content of photoactive components and the solvent used. The highest non-phototoxic concentrations obtained by the skin model assay proved to be a useful starting point for subsequent confirmatory human photopatch test aimed to identify safe concentration for human use. However, the highest non-phototoxic concentration obtained in the skin model assay cannot be applied directly for human practice (3 of 8 tested oils evoked a phototoxic reaction). A safety factor of 10 should be applied for extrapolation of experimental data from the skin model assay to man.

Authors+Show Affiliations

National Institute of Public Health, Šrobárova 48, 100 42 Prague 10, Czech Republic. kejlova@szu.czNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20688147

Citation

Kejlová, Kristina, et al. "Phototoxicity of Essential Oils Intended for Cosmetic Use." Toxicology in Vitro : an International Journal Published in Association With BIBRA, vol. 24, no. 8, 2010, pp. 2084-9.
Kejlová K, Jírová D, Bendová H, et al. Phototoxicity of essential oils intended for cosmetic use. Toxicol In Vitro. 2010;24(8):2084-9.
Kejlová, K., Jírová, D., Bendová, H., Gajdoš, P., & Kolářová, H. (2010). Phototoxicity of essential oils intended for cosmetic use. Toxicology in Vitro : an International Journal Published in Association With BIBRA, 24(8), pp. 2084-9. doi:10.1016/j.tiv.2010.07.025.
Kejlová K, et al. Phototoxicity of Essential Oils Intended for Cosmetic Use. Toxicol In Vitro. 2010;24(8):2084-9. PubMed PMID: 20688147.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Phototoxicity of essential oils intended for cosmetic use. AU - Kejlová,Kristina, AU - Jírová,Dagmar, AU - Bendová,Hana, AU - Gajdoš,Petr, AU - Kolářová,Hana, Y1 - 2010/08/03/ PY - 2009/10/23/received PY - 2010/06/17/revised PY - 2010/07/09/accepted PY - 2010/8/7/entrez PY - 2010/8/7/pubmed PY - 2011/1/11/medline SP - 2084 EP - 9 JF - Toxicology in vitro : an international journal published in association with BIBRA JO - Toxicol In Vitro VL - 24 IS - 8 N2 - The aim of this study, linked-up with a previous study on bergamot oils, was the evaluation of phototoxic potential of essential oils (orange, lemon and Litsea cubeba), used as cosmetic ingredients. The applied tiered testing strategy included chemical analysis of the substances (by means of capillary gas chromatography/mass spectrometry), in vitro 3T3 NRU phototoxicity test and EpiDerm™ skin phototoxicity test. In order to clarify the situation in man, the highest non-phototoxic/non-cytotoxic concentrations and concentrations 10 x lower (safety factor 10) were tested xin vivo by means of human skin photopatch test in a limited group of human volunteers. The study revealed, that phototoxicity of the essential oils was dependent on the content of photoactive components and the solvent used. The highest non-phototoxic concentrations obtained by the skin model assay proved to be a useful starting point for subsequent confirmatory human photopatch test aimed to identify safe concentration for human use. However, the highest non-phototoxic concentration obtained in the skin model assay cannot be applied directly for human practice (3 of 8 tested oils evoked a phototoxic reaction). A safety factor of 10 should be applied for extrapolation of experimental data from the skin model assay to man. SN - 1879-3177 UR - https://www.unboundmedicine.com/medline/citation/20688147/Phototoxicity_of_essential_oils_intended_for_cosmetic_use_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0887-2333(10)00186-4 DB - PRIME DP - Unbound Medicine ER -