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An outbreak of coxsackievirus A16 infection: comparison with other enteroviruses in a preschool in Taipei.
J Microbiol Immunol Infect. 2010 Aug; 43(4):271-7.JM

Abstract

BACKGROUND/PURPOSE

The transmission rate of enteroviruses in young children remains unclear. Therefore, we carried out active surveillance in preschool children to investigate the transmission rate and clinical manifestation of enteroviruses.

METHODS

From September 2006 to December 2008, we monitored infectious diseases in children 2(-3 years of age) in a preschool in Taipei. If any child had a febrile illness or symptoms/signs of enteroviral infection [e.g. herpangina or hand-foot-and-mouth disease (HFMD)], we performed viral isolation and enterovirus polymerase chain reaction. VP1 sequencing was performed to define their serotypes. We also collected clinical data and analyzed transmission rates.

RESULTS

There were eight episodes of enterovirus infection during the study period. The serotypes included coxsackievirus A4 (CA4), CA2 and CA16. The transmission rates of CA4 and CA2 among children in same class were 26% and 35%, respectively. Between November 28 and December 12, 2008, 13/21 (61.9%) children contracted herpangina and/or HFMD. The average age was 2.82 (range, 2.43-3.39) years. CA16 was detected in 10/13 (76.9%) of the throat swabs by polymerase chain reaction VP1 genotyping. Compared with previous CA2 and CA4 outbreaks, CA16 had a significantly higher transmission rate (p = 0.035) and resulted in more cases of HFMD (p < 0.001). The transmission duration of coxsackie A viruses within the same class ranged from 12 to 40 days.

CONCLUSION

Compared with CA2 and CA4, CA16 infections resulted in more cases of HFMD and had significantly higher transmission rates in preschoolers.

Authors+Show Affiliations

Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, 7 Chung-Shan South Road, Taipei, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20688286

Citation

Wu, Pei-Chieh, et al. "An Outbreak of Coxsackievirus A16 Infection: Comparison With Other Enteroviruses in a Preschool in Taipei." Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi, vol. 43, no. 4, 2010, pp. 271-7.
Wu PC, Huang LM, Kao CL, et al. An outbreak of coxsackievirus A16 infection: comparison with other enteroviruses in a preschool in Taipei. J Microbiol Immunol Infect. 2010;43(4):271-7.
Wu, P. C., Huang, L. M., Kao, C. L., Fan, T. Y., Cheng, A. L., & Chang, L. Y. (2010). An outbreak of coxsackievirus A16 infection: comparison with other enteroviruses in a preschool in Taipei. Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi, 43(4), 271-7. https://doi.org/10.1016/S1684-1182(10)60043-6
Wu PC, et al. An Outbreak of Coxsackievirus A16 Infection: Comparison With Other Enteroviruses in a Preschool in Taipei. J Microbiol Immunol Infect. 2010;43(4):271-7. PubMed PMID: 20688286.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An outbreak of coxsackievirus A16 infection: comparison with other enteroviruses in a preschool in Taipei. AU - Wu,Pei-Chieh, AU - Huang,Li-Min, AU - Kao,Chuan-Liang, AU - Fan,Tsui-Yen, AU - Cheng,Ai-Ling, AU - Chang,Luan-Yin, PY - 2008/12/15/received PY - 2009/04/02/revised PY - 2009/08/14/accepted PY - 2010/8/7/entrez PY - 2010/8/7/pubmed PY - 2010/11/11/medline SP - 271 EP - 7 JF - Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi JO - J Microbiol Immunol Infect VL - 43 IS - 4 N2 - BACKGROUND/PURPOSE: The transmission rate of enteroviruses in young children remains unclear. Therefore, we carried out active surveillance in preschool children to investigate the transmission rate and clinical manifestation of enteroviruses. METHODS: From September 2006 to December 2008, we monitored infectious diseases in children 2(-3 years of age) in a preschool in Taipei. If any child had a febrile illness or symptoms/signs of enteroviral infection [e.g. herpangina or hand-foot-and-mouth disease (HFMD)], we performed viral isolation and enterovirus polymerase chain reaction. VP1 sequencing was performed to define their serotypes. We also collected clinical data and analyzed transmission rates. RESULTS: There were eight episodes of enterovirus infection during the study period. The serotypes included coxsackievirus A4 (CA4), CA2 and CA16. The transmission rates of CA4 and CA2 among children in same class were 26% and 35%, respectively. Between November 28 and December 12, 2008, 13/21 (61.9%) children contracted herpangina and/or HFMD. The average age was 2.82 (range, 2.43-3.39) years. CA16 was detected in 10/13 (76.9%) of the throat swabs by polymerase chain reaction VP1 genotyping. Compared with previous CA2 and CA4 outbreaks, CA16 had a significantly higher transmission rate (p = 0.035) and resulted in more cases of HFMD (p < 0.001). The transmission duration of coxsackie A viruses within the same class ranged from 12 to 40 days. CONCLUSION: Compared with CA2 and CA4, CA16 infections resulted in more cases of HFMD and had significantly higher transmission rates in preschoolers. SN - 1995-9133 UR - https://www.unboundmedicine.com/medline/citation/20688286/An_outbreak_of_coxsackievirus_A16_infection:_comparison_with_other_enteroviruses_in_a_preschool_in_Taipei_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1684-1182(10)60043-6 DB - PRIME DP - Unbound Medicine ER -