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Comparison of Travoprost and Bimatoprost plus timolol fixed combinations in open-angle glaucoma patients previously treated with latanoprost plus timolol fixed combination.
Am J Ophthalmol 2010; 150(4):575-80AJ

Abstract

PURPOSE

To compare the ocular hypotensive effect of bimatoprost plus timolol and travoprost plus timolol fixed combinations in glaucoma patients whose disease was controlled but had not reached their target intraocular pressure (IOP) with the fixed combination of latanoprost plus timolol.

DESIGN

A 2 × 3-month, multicenter, prospective, randomized, double-masked, cross-over clinical trial.

METHODS

Eighty-nine open-angle glaucoma (OAG) patients were included. After a 6-week run-in period with latanoprost plus timolol, patients were randomized to either travoprost plus timolol or bimatoprost plus timolol for 3 months. Patients then switched to the opposite therapy for 3 additional months. The primary end point was the comparison of mean daily IOP after 3 months of each treatment.

RESULTS

At baseline, mean IOP was 16.5 mm Hg (95% confidence interval, 16.0 to 17.0 mm Hg) with treatment with latanoprost plus timolol. Both bimatoprost plus timolol and travoprost plus timolol statistically significantly reduced the mean IOP from baseline (P < .0001). Mean IOP at month 3 was statistically significantly lower in the bimatoprost plus timolol group compared with the travoprost plus timolol group (14.7 mm Hg [95% confidence interval, 14.3 to 15.3 mm Hg] vs 15.4 mm Hg [95% confidence interval, 15.0 to 15.9 mm Hg]; P = .0041). IOP was lower during bimatoprost plus timolol treatment at all time points and statistical significance was reached at 8 am, 11 am, and 5 pm, but not at 2 pm and 8 pm. Both treatments showed similar tolerability profile.

CONCLUSIONS

Bimatoprost plus timolol and travoprost plus timolol can provide additional IOP-lowering effect in patients not fully controlled with latanoprost plus timolol. The observed additional IOP reduction was greater with bimatoprost plus timolol with a similar tolerability profile.

Authors+Show Affiliations

Unità Dipartimentale Semplice di Glaucoma, University of Tor Vergata, Rome, Italy; Istituto di Ricovero e Cura a Carattere Scientifico Fondazione G.B. Bietti, Rome, Italy. marco.centofanti@fastwebnet.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20688314

Citation

Centofanti, Marco, et al. "Comparison of Travoprost and Bimatoprost Plus Timolol Fixed Combinations in Open-angle Glaucoma Patients Previously Treated With Latanoprost Plus Timolol Fixed Combination." American Journal of Ophthalmology, vol. 150, no. 4, 2010, pp. 575-80.
Centofanti M, Oddone F, Gandolfi S, et al. Comparison of Travoprost and Bimatoprost plus timolol fixed combinations in open-angle glaucoma patients previously treated with latanoprost plus timolol fixed combination. Am J Ophthalmol. 2010;150(4):575-80.
Centofanti, M., Oddone, F., Gandolfi, S., Hommer, A., Boehm, A., Tanga, L., ... Rossetti, L. (2010). Comparison of Travoprost and Bimatoprost plus timolol fixed combinations in open-angle glaucoma patients previously treated with latanoprost plus timolol fixed combination. American Journal of Ophthalmology, 150(4), pp. 575-80. doi:10.1016/j.ajo.2010.05.003.
Centofanti M, et al. Comparison of Travoprost and Bimatoprost Plus Timolol Fixed Combinations in Open-angle Glaucoma Patients Previously Treated With Latanoprost Plus Timolol Fixed Combination. Am J Ophthalmol. 2010;150(4):575-80. PubMed PMID: 20688314.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of Travoprost and Bimatoprost plus timolol fixed combinations in open-angle glaucoma patients previously treated with latanoprost plus timolol fixed combination. AU - Centofanti,Marco, AU - Oddone,Francesco, AU - Gandolfi,Stefano, AU - Hommer,Anton, AU - Boehm,Andreas, AU - Tanga,Lucia, AU - Sangermani,Chiara, AU - Sportelli,Vito, AU - Haustein,Michael, AU - Manni,Gianluca, AU - Rossetti,Luca, Y1 - 2010/08/04/ PY - 2010/01/12/received PY - 2010/05/04/revised PY - 2010/05/05/accepted PY - 2010/8/7/entrez PY - 2010/8/7/pubmed PY - 2010/10/7/medline SP - 575 EP - 80 JF - American journal of ophthalmology JO - Am. J. Ophthalmol. VL - 150 IS - 4 N2 - PURPOSE: To compare the ocular hypotensive effect of bimatoprost plus timolol and travoprost plus timolol fixed combinations in glaucoma patients whose disease was controlled but had not reached their target intraocular pressure (IOP) with the fixed combination of latanoprost plus timolol. DESIGN: A 2 × 3-month, multicenter, prospective, randomized, double-masked, cross-over clinical trial. METHODS: Eighty-nine open-angle glaucoma (OAG) patients were included. After a 6-week run-in period with latanoprost plus timolol, patients were randomized to either travoprost plus timolol or bimatoprost plus timolol for 3 months. Patients then switched to the opposite therapy for 3 additional months. The primary end point was the comparison of mean daily IOP after 3 months of each treatment. RESULTS: At baseline, mean IOP was 16.5 mm Hg (95% confidence interval, 16.0 to 17.0 mm Hg) with treatment with latanoprost plus timolol. Both bimatoprost plus timolol and travoprost plus timolol statistically significantly reduced the mean IOP from baseline (P < .0001). Mean IOP at month 3 was statistically significantly lower in the bimatoprost plus timolol group compared with the travoprost plus timolol group (14.7 mm Hg [95% confidence interval, 14.3 to 15.3 mm Hg] vs 15.4 mm Hg [95% confidence interval, 15.0 to 15.9 mm Hg]; P = .0041). IOP was lower during bimatoprost plus timolol treatment at all time points and statistical significance was reached at 8 am, 11 am, and 5 pm, but not at 2 pm and 8 pm. Both treatments showed similar tolerability profile. CONCLUSIONS: Bimatoprost plus timolol and travoprost plus timolol can provide additional IOP-lowering effect in patients not fully controlled with latanoprost plus timolol. The observed additional IOP reduction was greater with bimatoprost plus timolol with a similar tolerability profile. SN - 1879-1891 UR - https://www.unboundmedicine.com/medline/citation/20688314/Comparison_of_Travoprost_and_Bimatoprost_plus_timolol_fixed_combinations_in_open_angle_glaucoma_patients_previously_treated_with_latanoprost_plus_timolol_fixed_combination_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9394(10)00322-3 DB - PRIME DP - Unbound Medicine ER -