Tags

Type your tag names separated by a space and hit enter

Saturated fat intake and alcohol consumption modulate the association between the APOE polymorphism and risk of future coronary heart disease: a nested case-control study in the Spanish EPIC cohort.
J Nutr Biochem. 2011 May; 22(5):487-94.JN

Abstract

The association is still not clear between the common APOE polymorphism and coronary heart disease (CHD) risk, nor its modulation by diet. Thus, our aim was to study the association between the APOE genotypes and incident CHD and how dietary fat and alcohol consumption modify these effects. We performed a nested case-control study in the Spanish European Prospective Investigation into Cancer and Nutrition cohort. Healthy men and women (41,440, 30-69 years) were followed up over a 10-year period, with the incident CHD cases being identified. We analyzed 534 incident CHD cases and 1123 controls. APOE, dietary intake and plasma lipids were determined at baseline. The APOE polymorphism was significantly associated with low-density lipoprotein cholesterol (LDL-C), and gene-alcohol interactions in determining LDL-C were detected. In the whole population, the E2 allele was significantly associated with a lower CHD risk than E3/E3 subjects [odds ratio (OR), 0.58; 95% confidence interval (CI), 0.38-0.89]. The E4 allele did not reach statistical significance vs. E3/E3 (OR, 1.17; 95% CI, 0.88-1.58). However, saturated fat intake modified the effect of the APOE polymorphism in determining CHD risk. When saturated fat intake was low (<10% of energy), no statistically significant association between the APOE polymorphism and CHD risk was observed (P=.682). However, with higher intake (≥10%), the polymorphism was significant (P=.005), and the differences between E2 and E4 carriers were magnified (OR for E4 vs. E2, 3.33; 95% CI, 1.61-6.90). Alcohol consumption also modified the effect of the APOE on CHD risk. In conclusion, in this Mediterranean population, the E2 allele is associated with lower CHD risk, and this association is modulated by saturated fat and alcohol consumption.

Authors+Show Affiliations

Genetic and Molecular Epidemiology Unit, Department of Preventive Medicine, University of Valencia, Valencia and CIBER Fisiopatología de la Obesidad y Nutrición, ISCIII, Spain. dolores.corella@uv.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20688498

Citation

Corella, Dolores, et al. "Saturated Fat Intake and Alcohol Consumption Modulate the Association Between the APOE Polymorphism and Risk of Future Coronary Heart Disease: a Nested Case-control Study in the Spanish EPIC Cohort." The Journal of Nutritional Biochemistry, vol. 22, no. 5, 2011, pp. 487-94.
Corella D, Portolés O, Arriola L, et al. Saturated fat intake and alcohol consumption modulate the association between the APOE polymorphism and risk of future coronary heart disease: a nested case-control study in the Spanish EPIC cohort. J Nutr Biochem. 2011;22(5):487-94.
Corella, D., Portolés, O., Arriola, L., Chirlaque, M. D., Barrricarte, A., Francés, F., Huerta, J. M., Larrañaga, N., Martínez, C., Martinez-Camblor, P., Molina, E., Navarro, C., Quirós, J. R., Rodríguez, L., Sánchez, M. J., Ros, E., Sala, N., González, C. A., & Moreno-Iribas, C. (2011). Saturated fat intake and alcohol consumption modulate the association between the APOE polymorphism and risk of future coronary heart disease: a nested case-control study in the Spanish EPIC cohort. The Journal of Nutritional Biochemistry, 22(5), 487-94. https://doi.org/10.1016/j.jnutbio.2010.04.003
Corella D, et al. Saturated Fat Intake and Alcohol Consumption Modulate the Association Between the APOE Polymorphism and Risk of Future Coronary Heart Disease: a Nested Case-control Study in the Spanish EPIC Cohort. J Nutr Biochem. 2011;22(5):487-94. PubMed PMID: 20688498.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Saturated fat intake and alcohol consumption modulate the association between the APOE polymorphism and risk of future coronary heart disease: a nested case-control study in the Spanish EPIC cohort. AU - Corella,Dolores, AU - Portolés,Olga, AU - Arriola,Larraitz, AU - Chirlaque,María Dolores, AU - Barrricarte,Aurelio, AU - Francés,Francesc, AU - Huerta,José María, AU - Larrañaga,Nerea, AU - Martínez,Carmen, AU - Martinez-Camblor,Pablo, AU - Molina,Esther, AU - Navarro,Carmen, AU - Quirós,Jose R, AU - Rodríguez,Laudina, AU - Sánchez,María José, AU - Ros,Emilio, AU - Sala,Nuria, AU - González,Carlos A, AU - Moreno-Iribas,Concepción, Y1 - 2010/08/05/ PY - 2009/12/30/received PY - 2010/04/01/accepted PY - 2010/8/7/entrez PY - 2010/8/7/pubmed PY - 2011/8/16/medline SP - 487 EP - 94 JF - The Journal of nutritional biochemistry JO - J Nutr Biochem VL - 22 IS - 5 N2 - The association is still not clear between the common APOE polymorphism and coronary heart disease (CHD) risk, nor its modulation by diet. Thus, our aim was to study the association between the APOE genotypes and incident CHD and how dietary fat and alcohol consumption modify these effects. We performed a nested case-control study in the Spanish European Prospective Investigation into Cancer and Nutrition cohort. Healthy men and women (41,440, 30-69 years) were followed up over a 10-year period, with the incident CHD cases being identified. We analyzed 534 incident CHD cases and 1123 controls. APOE, dietary intake and plasma lipids were determined at baseline. The APOE polymorphism was significantly associated with low-density lipoprotein cholesterol (LDL-C), and gene-alcohol interactions in determining LDL-C were detected. In the whole population, the E2 allele was significantly associated with a lower CHD risk than E3/E3 subjects [odds ratio (OR), 0.58; 95% confidence interval (CI), 0.38-0.89]. The E4 allele did not reach statistical significance vs. E3/E3 (OR, 1.17; 95% CI, 0.88-1.58). However, saturated fat intake modified the effect of the APOE polymorphism in determining CHD risk. When saturated fat intake was low (<10% of energy), no statistically significant association between the APOE polymorphism and CHD risk was observed (P=.682). However, with higher intake (≥10%), the polymorphism was significant (P=.005), and the differences between E2 and E4 carriers were magnified (OR for E4 vs. E2, 3.33; 95% CI, 1.61-6.90). Alcohol consumption also modified the effect of the APOE on CHD risk. In conclusion, in this Mediterranean population, the E2 allele is associated with lower CHD risk, and this association is modulated by saturated fat and alcohol consumption. SN - 1873-4847 UR - https://www.unboundmedicine.com/medline/citation/20688498/Saturated_fat_intake_and_alcohol_consumption_modulate_the_association_between_the_APOE_polymorphism_and_risk_of_future_coronary_heart_disease:_a_nested_case_control_study_in_the_Spanish_EPIC_cohort_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0955-2863(10)00101-4 DB - PRIME DP - Unbound Medicine ER -