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Trace voltammetric detection of serotonin at carbon electrodes: comparison of glassy carbon, boron doped diamond and carbon nanotube network electrodes.
Phys Chem Chem Phys. 2010 Sep 14; 12(34):10108-14.PC

Abstract

The characteristics of three different carbon electrodes, glassy carbon (GC), oxygen-terminated polycrystalline boron-doped diamond (pBDD) and "pristine" carbon nanotube networks (CNTN) as voltammetric sensors for detection of the neurotransmitter serotonin have been investigated. For each electrode, detection sensitivity was determined using cyclic voltammetry (CV), a technique often used to provide information on chemical identity in electrochemical assays. The CNTN electrodes were found to exhibit background current densities ca. two orders of magnitude smaller than the GC electrode and ca. twenty times smaller than pBDD, as a consequence of their "pristine" low capacitance and low surface coverage. This was a major factor in determining serotonin detection limits from CV, of 10 nM for the CNTN electrode, 500 nM for pBDD and 2 microM for GC. The two most sensitive electrodes (CNTN and pBDD) were further investigated in terms of resistance to electrode fouling. CV analysis showed that fouling was less on the pBDD electrode compared to the CNTN and, furthermore, for the case of pBDD could be significantly minimised by careful selection of the CV potential limits, in particular by scanning the electrode potential to suitably cathodic values after oxidation of the serotonin.

Authors+Show Affiliations

Department of Chemistry, University of Warwick, Coventry, UK CV4 7AL.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

20689900

Citation

Güell, Aleix G., et al. "Trace Voltammetric Detection of Serotonin at Carbon Electrodes: Comparison of Glassy Carbon, Boron Doped Diamond and Carbon Nanotube Network Electrodes." Physical Chemistry Chemical Physics : PCCP, vol. 12, no. 34, 2010, pp. 10108-14.
Güell AG, Meadows KE, Unwin PR, et al. Trace voltammetric detection of serotonin at carbon electrodes: comparison of glassy carbon, boron doped diamond and carbon nanotube network electrodes. Phys Chem Chem Phys. 2010;12(34):10108-14.
Güell, A. G., Meadows, K. E., Unwin, P. R., & Macpherson, J. V. (2010). Trace voltammetric detection of serotonin at carbon electrodes: comparison of glassy carbon, boron doped diamond and carbon nanotube network electrodes. Physical Chemistry Chemical Physics : PCCP, 12(34), 10108-14. https://doi.org/10.1039/c0cp00675k
Güell AG, et al. Trace Voltammetric Detection of Serotonin at Carbon Electrodes: Comparison of Glassy Carbon, Boron Doped Diamond and Carbon Nanotube Network Electrodes. Phys Chem Chem Phys. 2010 Sep 14;12(34):10108-14. PubMed PMID: 20689900.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Trace voltammetric detection of serotonin at carbon electrodes: comparison of glassy carbon, boron doped diamond and carbon nanotube network electrodes. AU - Güell,Aleix G, AU - Meadows,Katherine E, AU - Unwin,Patrick R, AU - Macpherson,Julie V, Y1 - 2010/08/06/ PY - 2010/8/7/entrez PY - 2010/8/7/pubmed PY - 2010/12/14/medline SP - 10108 EP - 14 JF - Physical chemistry chemical physics : PCCP JO - Phys Chem Chem Phys VL - 12 IS - 34 N2 - The characteristics of three different carbon electrodes, glassy carbon (GC), oxygen-terminated polycrystalline boron-doped diamond (pBDD) and "pristine" carbon nanotube networks (CNTN) as voltammetric sensors for detection of the neurotransmitter serotonin have been investigated. For each electrode, detection sensitivity was determined using cyclic voltammetry (CV), a technique often used to provide information on chemical identity in electrochemical assays. The CNTN electrodes were found to exhibit background current densities ca. two orders of magnitude smaller than the GC electrode and ca. twenty times smaller than pBDD, as a consequence of their "pristine" low capacitance and low surface coverage. This was a major factor in determining serotonin detection limits from CV, of 10 nM for the CNTN electrode, 500 nM for pBDD and 2 microM for GC. The two most sensitive electrodes (CNTN and pBDD) were further investigated in terms of resistance to electrode fouling. CV analysis showed that fouling was less on the pBDD electrode compared to the CNTN and, furthermore, for the case of pBDD could be significantly minimised by careful selection of the CV potential limits, in particular by scanning the electrode potential to suitably cathodic values after oxidation of the serotonin. SN - 1463-9084 UR - https://www.unboundmedicine.com/medline/citation/20689900/Trace_voltammetric_detection_of_serotonin_at_carbon_electrodes:_comparison_of_glassy_carbon_boron_doped_diamond_and_carbon_nanotube_network_electrodes_ L2 - https://doi.org/10.1039/c0cp00675k DB - PRIME DP - Unbound Medicine ER -