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Clinical implication of gastrointestinal bleeding in degenerative aortic stenosis: an update.
Cardiol J. 2010; 17(4):330-4.CJ

Abstract

Gastrointestinal (GI) bleeding due to colonic angiodysplasias can be associated with calcifying aortic stenosis (AS). GI angiodysplasias and AS are defined as chronic degenerative disorders, and the prevalence of both diseases increases with age. Moreover, degenerative AS is associated with increased destruction of high molecular weight multimers of von Willebrand factor which can promote bleeding from intestinal angiodysplasias. The coincidence of gastrointestinal bleeding angiodysplasias and AS has been known for many years as Heyde's syndrome. Aortic valve replacement is the first line therapy for advanced stage AS-patients, but can also be an effective treatment for co-existent bleeding angiodysplasias and acquired von Willebrand disease. In this study, we tried to collect as well as systemized data about the etiopathogenesis of AS coagulation abnormalities and diagnostic, clinical and therapeutic implications of AS-patient with GI angiodysplasias.

Authors+Show Affiliations

Department of Cardiology, Sterling Memorial University Hospital, Medical University of Łódź, Sterlinga 1/3, Łódź, Poland. golawojtek@gmail.comNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

20690087

Citation

Gola, Wojciech, and Małgorzata Lelonek. "Clinical Implication of Gastrointestinal Bleeding in Degenerative Aortic Stenosis: an Update." Cardiology Journal, vol. 17, no. 4, 2010, pp. 330-4.
Gola W, Lelonek M. Clinical implication of gastrointestinal bleeding in degenerative aortic stenosis: an update. Cardiol J. 2010;17(4):330-4.
Gola, W., & Lelonek, M. (2010). Clinical implication of gastrointestinal bleeding in degenerative aortic stenosis: an update. Cardiology Journal, 17(4), 330-4.
Gola W, Lelonek M. Clinical Implication of Gastrointestinal Bleeding in Degenerative Aortic Stenosis: an Update. Cardiol J. 2010;17(4):330-4. PubMed PMID: 20690087.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical implication of gastrointestinal bleeding in degenerative aortic stenosis: an update. AU - Gola,Wojciech, AU - Lelonek,Małgorzata, PY - 2010/8/7/entrez PY - 2010/8/7/pubmed PY - 2010/12/14/medline SP - 330 EP - 4 JF - Cardiology journal JO - Cardiol J VL - 17 IS - 4 N2 - Gastrointestinal (GI) bleeding due to colonic angiodysplasias can be associated with calcifying aortic stenosis (AS). GI angiodysplasias and AS are defined as chronic degenerative disorders, and the prevalence of both diseases increases with age. Moreover, degenerative AS is associated with increased destruction of high molecular weight multimers of von Willebrand factor which can promote bleeding from intestinal angiodysplasias. The coincidence of gastrointestinal bleeding angiodysplasias and AS has been known for many years as Heyde's syndrome. Aortic valve replacement is the first line therapy for advanced stage AS-patients, but can also be an effective treatment for co-existent bleeding angiodysplasias and acquired von Willebrand disease. In this study, we tried to collect as well as systemized data about the etiopathogenesis of AS coagulation abnormalities and diagnostic, clinical and therapeutic implications of AS-patient with GI angiodysplasias. SN - 1897-5593 UR - https://www.unboundmedicine.com/medline/citation/20690087/Clinical_implication_of_gastrointestinal_bleeding_in_degenerative_aortic_stenosis:_an_update_ L2 - http://www.cardiologyjournal.org/en/darmowy_pdf.phtml?id=97&indeks_art=1334 DB - PRIME DP - Unbound Medicine ER -