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Synthesis, molecular docking and biological evaluation of Schiff base transition metal complexes as potential urease inhibitors.
Eur J Med Chem. 2010 Oct; 45(10):4473-8.EJ

Abstract

Six transition metal compounds of Schiff base ligands were evaluated for the inhibitory activity on jack bean urease, of which compounds 2-6 were determined by single crystal X-ray analysis. It was found that copper(II) complexes 1 and 4 showed strong inhibitory activity against jack bean urease (IC(50) = 0.52 and 0.46 microM), compared with acetohydroxamic acid (IC(50) = 42.12 microM) as a positive reference. Cobalt(II), nickel(II) and zinc(II) compounds also exhibited potent inhibitory activity (IC(50) = 3.88-25.20 microM). A docking analysis using the AUTODOCK 4.0 program could explain the inhibitory activities of 1 and 4 against urease.

Authors+Show Affiliations

Engineering Research Center for Clean Production of Textile Printing, Ministry of Education, Wuhan Textile University, Wuhan 430073, People's Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20691510

Citation

Chen, Wu, et al. "Synthesis, Molecular Docking and Biological Evaluation of Schiff Base Transition Metal Complexes as Potential Urease Inhibitors." European Journal of Medicinal Chemistry, vol. 45, no. 10, 2010, pp. 4473-8.
Chen W, Li Y, Cui Y, et al. Synthesis, molecular docking and biological evaluation of Schiff base transition metal complexes as potential urease inhibitors. Eur J Med Chem. 2010;45(10):4473-8.
Chen, W., Li, Y., Cui, Y., Zhang, X., Zhu, H. L., & Zeng, Q. (2010). Synthesis, molecular docking and biological evaluation of Schiff base transition metal complexes as potential urease inhibitors. European Journal of Medicinal Chemistry, 45(10), 4473-8. https://doi.org/10.1016/j.ejmech.2010.07.007
Chen W, et al. Synthesis, Molecular Docking and Biological Evaluation of Schiff Base Transition Metal Complexes as Potential Urease Inhibitors. Eur J Med Chem. 2010;45(10):4473-8. PubMed PMID: 20691510.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synthesis, molecular docking and biological evaluation of Schiff base transition metal complexes as potential urease inhibitors. AU - Chen,Wu, AU - Li,Yuguang, AU - Cui,Yongming, AU - Zhang,Xian, AU - Zhu,Hai-Liang, AU - Zeng,Qingfu, Y1 - 2010/07/14/ PY - 2010/03/16/received PY - 2010/06/12/revised PY - 2010/07/05/accepted PY - 2010/8/10/entrez PY - 2010/8/10/pubmed PY - 2010/12/29/medline SP - 4473 EP - 8 JF - European journal of medicinal chemistry JO - Eur J Med Chem VL - 45 IS - 10 N2 - Six transition metal compounds of Schiff base ligands were evaluated for the inhibitory activity on jack bean urease, of which compounds 2-6 were determined by single crystal X-ray analysis. It was found that copper(II) complexes 1 and 4 showed strong inhibitory activity against jack bean urease (IC(50) = 0.52 and 0.46 microM), compared with acetohydroxamic acid (IC(50) = 42.12 microM) as a positive reference. Cobalt(II), nickel(II) and zinc(II) compounds also exhibited potent inhibitory activity (IC(50) = 3.88-25.20 microM). A docking analysis using the AUTODOCK 4.0 program could explain the inhibitory activities of 1 and 4 against urease. SN - 1768-3254 UR - https://www.unboundmedicine.com/medline/citation/20691510/Synthesis_molecular_docking_and_biological_evaluation_of_Schiff_base_transition_metal_complexes_as_potential_urease_inhibitors_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0223-5234(10)00487-3 DB - PRIME DP - Unbound Medicine ER -