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Association to the Glypican-5 gene in multiple sclerosis.
J Neuroimmunol 2010; 226(1-2):194-7JN

Abstract

Multiple sclerosis (MS) is an inflammatory, demyelinating disease affecting the central nervous system. MS-associated variants have been reported at both HLA and non-HLA loci, the latter including chromosome 13q31-32 and the Glypican-5 and Glypican-6 genes. In order to further explore the 13q31-32 region in MS, we genotyped 33 SNPs in 1355 Norwegian MS patients and 1446 Norwegian controls. An intronic SNP in the Glypican-5 gene (rs9523787) showed association with MS (p(corr)=0.006). Thus, this study supports that MS susceptibility at 13q31-32 may localize to the Glypican-5 gene, which should lead to further fine-mapping, replication and functional studies of this gene.

Authors+Show Affiliations

Department of Neurology, Oslo University Hospital, Ullevål, University of Oslo, Oslo, Norway. aslaug.r.lorentzen@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20692050

Citation

Lorentzen, Aslaug R., et al. "Association to the Glypican-5 Gene in Multiple Sclerosis." Journal of Neuroimmunology, vol. 226, no. 1-2, 2010, pp. 194-7.
Lorentzen AR, Melum E, Ellinghaus E, et al. Association to the Glypican-5 gene in multiple sclerosis. J Neuroimmunol. 2010;226(1-2):194-7.
Lorentzen, A. R., Melum, E., Ellinghaus, E., Smestad, C., Mero, I. L., Aarseth, J. H., ... Harbo, H. F. (2010). Association to the Glypican-5 gene in multiple sclerosis. Journal of Neuroimmunology, 226(1-2), pp. 194-7. doi:10.1016/j.jneuroim.2010.07.003.
Lorentzen AR, et al. Association to the Glypican-5 Gene in Multiple Sclerosis. J Neuroimmunol. 2010 Sep 14;226(1-2):194-7. PubMed PMID: 20692050.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association to the Glypican-5 gene in multiple sclerosis. AU - Lorentzen,Aslaug R, AU - Melum,Espen, AU - Ellinghaus,Eva, AU - Smestad,Cathrine, AU - Mero,Inger-Lise, AU - Aarseth,Jan H, AU - Myhr,Kjell-Morten, AU - Celius,Elisabeth G, AU - Lie,Benedicte A, AU - Karlsen,Tom H, AU - Franke,Andre, AU - Harbo,Hanne F, Y1 - 2010/08/06/ PY - 2010/05/22/received PY - 2010/07/02/revised PY - 2010/07/06/accepted PY - 2010/8/10/entrez PY - 2010/8/10/pubmed PY - 2010/10/7/medline SP - 194 EP - 7 JF - Journal of neuroimmunology JO - J. Neuroimmunol. VL - 226 IS - 1-2 N2 - Multiple sclerosis (MS) is an inflammatory, demyelinating disease affecting the central nervous system. MS-associated variants have been reported at both HLA and non-HLA loci, the latter including chromosome 13q31-32 and the Glypican-5 and Glypican-6 genes. In order to further explore the 13q31-32 region in MS, we genotyped 33 SNPs in 1355 Norwegian MS patients and 1446 Norwegian controls. An intronic SNP in the Glypican-5 gene (rs9523787) showed association with MS (p(corr)=0.006). Thus, this study supports that MS susceptibility at 13q31-32 may localize to the Glypican-5 gene, which should lead to further fine-mapping, replication and functional studies of this gene. SN - 1872-8421 UR - https://www.unboundmedicine.com/medline/citation/20692050/Association_to_the_Glypican_5_gene_in_multiple_sclerosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-5728(10)00294-8 DB - PRIME DP - Unbound Medicine ER -