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Association to the Glypican-5 gene in multiple sclerosis.

Abstract

Multiple sclerosis (MS) is an inflammatory, demyelinating disease affecting the central nervous system. MS-associated variants have been reported at both HLA and non-HLA loci, the latter including chromosome 13q31-32 and the Glypican-5 and Glypican-6 genes. In order to further explore the 13q31-32 region in MS, we genotyped 33 SNPs in 1355 Norwegian MS patients and 1446 Norwegian controls. An intronic SNP in the Glypican-5 gene (rs9523787) showed association with MS (p(corr)=0.006). Thus, this study supports that MS susceptibility at 13q31-32 may localize to the Glypican-5 gene, which should lead to further fine-mapping, replication and functional studies of this gene.

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  • Authors+Show Affiliations

    ,

    Department of Neurology, Oslo University Hospital, Ullevål, University of Oslo, Oslo, Norway. aslaug.r.lorentzen@gmail.com

    , , , , , , , , , ,

    Source

    Journal of neuroimmunology 226:1-2 2010 Sep 14 pg 194-7

    MeSH

    Adolescent
    Adult
    Aged
    Case-Control Studies
    Child
    Chromosomes, Human, Pair 13
    Female
    Genetic Predisposition to Disease
    Genome-Wide Association Study
    Glypicans
    Humans
    Linkage Disequilibrium
    Male
    Middle Aged
    Multiple Sclerosis
    Norway
    Polymorphism, Single Nucleotide
    Young Adult

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    20692050

    Citation

    Lorentzen, Aslaug R., et al. "Association to the Glypican-5 Gene in Multiple Sclerosis." Journal of Neuroimmunology, vol. 226, no. 1-2, 2010, pp. 194-7.
    Lorentzen AR, Melum E, Ellinghaus E, et al. Association to the Glypican-5 gene in multiple sclerosis. J Neuroimmunol. 2010;226(1-2):194-7.
    Lorentzen, A. R., Melum, E., Ellinghaus, E., Smestad, C., Mero, I. L., Aarseth, J. H., ... Harbo, H. F. (2010). Association to the Glypican-5 gene in multiple sclerosis. Journal of Neuroimmunology, 226(1-2), pp. 194-7. doi:10.1016/j.jneuroim.2010.07.003.
    Lorentzen AR, et al. Association to the Glypican-5 Gene in Multiple Sclerosis. J Neuroimmunol. 2010 Sep 14;226(1-2):194-7. PubMed PMID: 20692050.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Association to the Glypican-5 gene in multiple sclerosis. AU - Lorentzen,Aslaug R, AU - Melum,Espen, AU - Ellinghaus,Eva, AU - Smestad,Cathrine, AU - Mero,Inger-Lise, AU - Aarseth,Jan H, AU - Myhr,Kjell-Morten, AU - Celius,Elisabeth G, AU - Lie,Benedicte A, AU - Karlsen,Tom H, AU - Franke,Andre, AU - Harbo,Hanne F, Y1 - 2010/08/06/ PY - 2010/05/22/received PY - 2010/07/02/revised PY - 2010/07/06/accepted PY - 2010/8/10/entrez PY - 2010/8/10/pubmed PY - 2010/10/7/medline SP - 194 EP - 7 JF - Journal of neuroimmunology JO - J. Neuroimmunol. VL - 226 IS - 1-2 N2 - Multiple sclerosis (MS) is an inflammatory, demyelinating disease affecting the central nervous system. MS-associated variants have been reported at both HLA and non-HLA loci, the latter including chromosome 13q31-32 and the Glypican-5 and Glypican-6 genes. In order to further explore the 13q31-32 region in MS, we genotyped 33 SNPs in 1355 Norwegian MS patients and 1446 Norwegian controls. An intronic SNP in the Glypican-5 gene (rs9523787) showed association with MS (p(corr)=0.006). Thus, this study supports that MS susceptibility at 13q31-32 may localize to the Glypican-5 gene, which should lead to further fine-mapping, replication and functional studies of this gene. SN - 1872-8421 UR - https://www.unboundmedicine.com/medline/citation/20692050/Association_to_the_Glypican_5_gene_in_multiple_sclerosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-5728(10)00294-8 DB - PRIME DP - Unbound Medicine ER -