Association to the Glypican-5 gene in multiple sclerosis.
Multiple sclerosis (MS) is an inflammatory, demyelinating disease affecting the central nervous system. MS-associated variants have been reported at both HLA and non-HLA loci, the latter including chromosome 13q31-32 and the Glypican-5 and Glypican-6 genes. In order to further explore the 13q31-32 region in MS, we genotyped 33 SNPs in 1355 Norwegian MS patients and 1446 Norwegian controls. An intronic SNP in the Glypican-5 gene (rs9523787) showed association with MS (p(corr)=0.006). Thus, this study supports that MS susceptibility at 13q31-32 may localize to the Glypican-5 gene, which should lead to further fine-mapping, replication and functional studies of this gene.
Department of Neurology, Oslo University Hospital, Ullevål, University of Oslo, Oslo, Norway. firstname.lastname@example.org, , , , , , , , , ,
Chromosomes, Human, Pair 13
Genetic Predisposition to Disease
Genome-Wide Association Study
Polymorphism, Single Nucleotide
Pub Type(s)Journal Article
Research Support, Non-U.S. Gov't