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African Burkitt's lymphoma. History, biology, clinical features, and treatment.
Am J Pediatr Hematol Oncol 1991; 13(2):222-46AJ

Abstract

Dennis Burkitt's first description of the African tumor that is now known by his name appeared in 1958. In the brief intervening span of 32 years, this lymphoma has provided an extraordinarily valuable paradigm that has afforded insights into topics that encompass the entire discipline of oncology. These include the origins of lymphoid neoplasms at epidemiological, cellular, and molecular levels, and the efficacy of chemotherapy in rapidly progressive, widely disseminated lymphomas. In addition, epidemiological considerations led to the discovery of a new virus, the Epstein-Barr virus, which has proved to be an important human pathogen. This virus probably plays a pathogenetic role in several neoplastic diseases, including the lymphoproliferative syndromes associated with inherited and acquired immunodeficiency. Small, noncleaved cell lymphoma is the latest histological designation of the category of lymphomas that includes Burkitt's lymphoma. This tumor, which is biologically heterogeneous, has become notorious because of its high incidence in individuals infected with the human immunodeficiency virus, which is providing a second, potentially fertile model for the exploration of the pathogenesis of lymphoid neoplasms. Already, enough is known of the pathogenesis of Burkitt's lymphoma to permit the first tentative steps toward the development of novel therapeutic approaches directed toward the molecular genetic abnormalities associated with the neoplasm. In this article, the history, biology, clinical features, and treatment of African Burkitt's lymphoma are reviewed.

Authors+Show Affiliations

Pediatric Branch, National Cancer Institute, Bethesda, Maryland 20892.

Pub Type(s)

Historical Article
Journal Article
Review

Language

eng

PubMed ID

2069232

Citation

Magrath, I T.. "African Burkitt's Lymphoma. History, Biology, Clinical Features, and Treatment." The American Journal of Pediatric Hematology/oncology, vol. 13, no. 2, 1991, pp. 222-46.
Magrath IT. African Burkitt's lymphoma. History, biology, clinical features, and treatment. Am J Pediatr Hematol Oncol. 1991;13(2):222-46.
Magrath, I. T. (1991). African Burkitt's lymphoma. History, biology, clinical features, and treatment. The American Journal of Pediatric Hematology/oncology, 13(2), pp. 222-46.
Magrath IT. African Burkitt's Lymphoma. History, Biology, Clinical Features, and Treatment. Am J Pediatr Hematol Oncol. 1991;13(2):222-46. PubMed PMID: 2069232.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - African Burkitt's lymphoma. History, biology, clinical features, and treatment. A1 - Magrath,I T, PY - 1991/1/1/pubmed PY - 1991/1/1/medline PY - 1991/1/1/entrez SP - 222 EP - 46 JF - The American journal of pediatric hematology/oncology JO - Am J Pediatr Hematol Oncol VL - 13 IS - 2 N2 - Dennis Burkitt's first description of the African tumor that is now known by his name appeared in 1958. In the brief intervening span of 32 years, this lymphoma has provided an extraordinarily valuable paradigm that has afforded insights into topics that encompass the entire discipline of oncology. These include the origins of lymphoid neoplasms at epidemiological, cellular, and molecular levels, and the efficacy of chemotherapy in rapidly progressive, widely disseminated lymphomas. In addition, epidemiological considerations led to the discovery of a new virus, the Epstein-Barr virus, which has proved to be an important human pathogen. This virus probably plays a pathogenetic role in several neoplastic diseases, including the lymphoproliferative syndromes associated with inherited and acquired immunodeficiency. Small, noncleaved cell lymphoma is the latest histological designation of the category of lymphomas that includes Burkitt's lymphoma. This tumor, which is biologically heterogeneous, has become notorious because of its high incidence in individuals infected with the human immunodeficiency virus, which is providing a second, potentially fertile model for the exploration of the pathogenesis of lymphoid neoplasms. Already, enough is known of the pathogenesis of Burkitt's lymphoma to permit the first tentative steps toward the development of novel therapeutic approaches directed toward the molecular genetic abnormalities associated with the neoplasm. In this article, the history, biology, clinical features, and treatment of African Burkitt's lymphoma are reviewed. SN - 0192-8562 UR - https://www.unboundmedicine.com/medline/citation/2069232/African_Burkitt's_lymphoma__History_biology_clinical_features_and_treatment_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=2069232.ui DB - PRIME DP - Unbound Medicine ER -