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Lead exposure is associated with a delay in the onset of puberty in South African adolescent females: findings from the Birth to Twenty cohort.
Sci Total Environ. 2010 Oct 01; 408(21):4949-54.ST

Abstract

INTRODUCTION

One of the suggested, yet under-researched, causes of pubertal delay is lead exposure. In South Africa blood lead levels are generally higher than in resource-rich countries. Thus the effects of lead exposure on pubertal development may be significant.

OBJECTIVE

The objective of this study is to determine the association between lead exposure and pubertal development in adolescent females in the Birth to Twenty cohort (Bt20).

METHODS

Bt20 is a Johannesburg based birth cohort study that commenced in 1990 and includes 1682 girls. At 13 years of age venous blood samples were collected from 725 adolescent female participants for lead content analyses; of these, 712 had menarche data. Pubertal measurement was based on age of menarche and self-reported Tanner staging for pubic hair (n=684) and breast development (n=682).

RESULTS

The mean blood lead level for the sample was 4.9 microg/dl. Fifty percent had blood lead levels <5.0 microg/dl, 49% were > or = 5.0 microg/dl and 1% was >10.0 microg/dl. The average age of menarche was 12.7 years. At 13 years, 4% and 7% had reached Tanner stage 5 for pubic hair and breast development, respectively. Analyses showed that higher blood lead levels were associated with significant delays in the onset of puberty (p<0.001).

CONCLUSION

The study found that higher blood lead levels were associated with a delay in the onset of puberty, after adjustment for confounders. Lead exposure in resource-poor countries is generally higher compared to resource-rich countries and thus the effects of high blood levels have personal and public health significance.

Authors+Show Affiliations

Medical Research Council of South Africa, Environment and Health Research Unit, PO Box 87373, Houghton, 2041, Johannesburg, South Africa. Nisha.naicker@mrc.ac.zaNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20692685

Citation

Naicker, Nisha, et al. "Lead Exposure Is Associated With a Delay in the Onset of Puberty in South African Adolescent Females: Findings From the Birth to Twenty Cohort." The Science of the Total Environment, vol. 408, no. 21, 2010, pp. 4949-54.
Naicker N, Norris SA, Mathee A, et al. Lead exposure is associated with a delay in the onset of puberty in South African adolescent females: findings from the Birth to Twenty cohort. Sci Total Environ. 2010;408(21):4949-54.
Naicker, N., Norris, S. A., Mathee, A., Becker, P., & Richter, L. (2010). Lead exposure is associated with a delay in the onset of puberty in South African adolescent females: findings from the Birth to Twenty cohort. The Science of the Total Environment, 408(21), 4949-54. https://doi.org/10.1016/j.scitotenv.2010.07.037
Naicker N, et al. Lead Exposure Is Associated With a Delay in the Onset of Puberty in South African Adolescent Females: Findings From the Birth to Twenty Cohort. Sci Total Environ. 2010 Oct 1;408(21):4949-54. PubMed PMID: 20692685.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lead exposure is associated with a delay in the onset of puberty in South African adolescent females: findings from the Birth to Twenty cohort. AU - Naicker,Nisha, AU - Norris,Shane A, AU - Mathee,Angela, AU - Becker,Piet, AU - Richter,Linda, Y1 - 2010/08/07/ PY - 2010/04/12/received PY - 2010/07/07/revised PY - 2010/07/14/accepted PY - 2010/8/10/entrez PY - 2010/8/10/pubmed PY - 2010/10/30/medline SP - 4949 EP - 54 JF - The Science of the total environment JO - Sci Total Environ VL - 408 IS - 21 N2 - INTRODUCTION: One of the suggested, yet under-researched, causes of pubertal delay is lead exposure. In South Africa blood lead levels are generally higher than in resource-rich countries. Thus the effects of lead exposure on pubertal development may be significant. OBJECTIVE: The objective of this study is to determine the association between lead exposure and pubertal development in adolescent females in the Birth to Twenty cohort (Bt20). METHODS: Bt20 is a Johannesburg based birth cohort study that commenced in 1990 and includes 1682 girls. At 13 years of age venous blood samples were collected from 725 adolescent female participants for lead content analyses; of these, 712 had menarche data. Pubertal measurement was based on age of menarche and self-reported Tanner staging for pubic hair (n=684) and breast development (n=682). RESULTS: The mean blood lead level for the sample was 4.9 microg/dl. Fifty percent had blood lead levels <5.0 microg/dl, 49% were > or = 5.0 microg/dl and 1% was >10.0 microg/dl. The average age of menarche was 12.7 years. At 13 years, 4% and 7% had reached Tanner stage 5 for pubic hair and breast development, respectively. Analyses showed that higher blood lead levels were associated with significant delays in the onset of puberty (p<0.001). CONCLUSION: The study found that higher blood lead levels were associated with a delay in the onset of puberty, after adjustment for confounders. Lead exposure in resource-poor countries is generally higher compared to resource-rich countries and thus the effects of high blood levels have personal and public health significance. SN - 1879-1026 UR - https://www.unboundmedicine.com/medline/citation/20692685/Lead_exposure_is_associated_with_a_delay_in_the_onset_of_puberty_in_South_African_adolescent_females:_findings_from_the_Birth_to_Twenty_cohort_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0048-9697(10)00731-X DB - PRIME DP - Unbound Medicine ER -