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Concurrent comparison of epidemiology, clinical presentation and outcome between adult patients suffering from the pandemic influenza A (H1N1) 2009 virus and the seasonal influenza A virus infection.
Postgrad Med J 2010; 86(1019):515-21PM

Abstract

PURPOSE OF STUDY

The demographics, clinical features and outcome of patients with pandemic influenza A (H1N1) 2009 infection were compared with a concurrent cohort of patients with seasonal influenza A infection.

STUDY DESIGN

The clinical and microbiological data of hospitalised adult patients admitted between 29 June and 28 October 2009, with pandemic A (H1N1) 2009 or seasonal influenza A infection, were analysed.

RESULTS

A total of 186 patients including 69 pandemic A (H1N1) and 117 seasonal influenza were analysed. The majority (75%) under 50 years of age had pandemic A (H1N1). Compared with seasonal influenza, pandemic A (H1N1) patients were younger (median age 47 years vs 76 years, p<0.001), less likely to have lower respiratory tract symptoms (46.4% vs 66.7%, p=0.007), but more likely to be obese (5.8% vs 0%, p=0.018), pregnant (7.2% vs 0.9%, p=0.027) or have no underlying predisposing factors (24.6% vs 5.1%, p<0.001). Patients with pandemic A (H1N1) were more likely to receive oseltamivir (91.3% vs 40.2%, p<0.001), but less likely to receive antibiotics (75.4% vs 90.6%, p=0.005). Respiratory failure was the reason for intensive care unit admission for all four patients with pandemic A (H1N1), but only for one of three patients with seasonal influenza. There were no statistical significant differences in the rate of intensive care unit admission or death.

CONCLUSIONS

In addition to age, several clinical parameters were different between pandemic A (H1N1) and seasonal influenza. However, since both seasonal and pandemic influenza can lead to significant morbidity and mortality, the impact of pre-existing seasonal influenza should not be underestimated during the pandemic period.

Authors+Show Affiliations

Carol Yu Centre for Infection, The University of Hong Kong, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20693151

Citation

To, Kelvin K W., et al. "Concurrent Comparison of Epidemiology, Clinical Presentation and Outcome Between Adult Patients Suffering From the Pandemic Influenza a (H1N1) 2009 Virus and the Seasonal Influenza a Virus Infection." Postgraduate Medical Journal, vol. 86, no. 1019, 2010, pp. 515-21.
To KK, Wong SS, Li IW, et al. Concurrent comparison of epidemiology, clinical presentation and outcome between adult patients suffering from the pandemic influenza A (H1N1) 2009 virus and the seasonal influenza A virus infection. Postgrad Med J. 2010;86(1019):515-21.
To, K. K., Wong, S. S., Li, I. W., Hung, I. F., Tse, H., Woo, P. C., ... Yuen, K. Y. (2010). Concurrent comparison of epidemiology, clinical presentation and outcome between adult patients suffering from the pandemic influenza A (H1N1) 2009 virus and the seasonal influenza A virus infection. Postgraduate Medical Journal, 86(1019), pp. 515-21. doi:10.1136/pgmj.2009.096206.
To KK, et al. Concurrent Comparison of Epidemiology, Clinical Presentation and Outcome Between Adult Patients Suffering From the Pandemic Influenza a (H1N1) 2009 Virus and the Seasonal Influenza a Virus Infection. Postgrad Med J. 2010;86(1019):515-21. PubMed PMID: 20693151.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Concurrent comparison of epidemiology, clinical presentation and outcome between adult patients suffering from the pandemic influenza A (H1N1) 2009 virus and the seasonal influenza A virus infection. AU - To,Kelvin K W, AU - Wong,Samson S Y, AU - Li,Iris W S, AU - Hung,Ivan F N, AU - Tse,Herman, AU - Woo,Patrick C Y, AU - Chan,Kwok-Hung, AU - Yuen,Kwok-Yung, Y1 - 2010/08/05/ PY - 2010/8/10/entrez PY - 2010/8/10/pubmed PY - 2011/12/13/medline SP - 515 EP - 21 JF - Postgraduate medical journal JO - Postgrad Med J VL - 86 IS - 1019 N2 - PURPOSE OF STUDY: The demographics, clinical features and outcome of patients with pandemic influenza A (H1N1) 2009 infection were compared with a concurrent cohort of patients with seasonal influenza A infection. STUDY DESIGN: The clinical and microbiological data of hospitalised adult patients admitted between 29 June and 28 October 2009, with pandemic A (H1N1) 2009 or seasonal influenza A infection, were analysed. RESULTS: A total of 186 patients including 69 pandemic A (H1N1) and 117 seasonal influenza were analysed. The majority (75%) under 50 years of age had pandemic A (H1N1). Compared with seasonal influenza, pandemic A (H1N1) patients were younger (median age 47 years vs 76 years, p<0.001), less likely to have lower respiratory tract symptoms (46.4% vs 66.7%, p=0.007), but more likely to be obese (5.8% vs 0%, p=0.018), pregnant (7.2% vs 0.9%, p=0.027) or have no underlying predisposing factors (24.6% vs 5.1%, p<0.001). Patients with pandemic A (H1N1) were more likely to receive oseltamivir (91.3% vs 40.2%, p<0.001), but less likely to receive antibiotics (75.4% vs 90.6%, p=0.005). Respiratory failure was the reason for intensive care unit admission for all four patients with pandemic A (H1N1), but only for one of three patients with seasonal influenza. There were no statistical significant differences in the rate of intensive care unit admission or death. CONCLUSIONS: In addition to age, several clinical parameters were different between pandemic A (H1N1) and seasonal influenza. However, since both seasonal and pandemic influenza can lead to significant morbidity and mortality, the impact of pre-existing seasonal influenza should not be underestimated during the pandemic period. SN - 1469-0756 UR - https://www.unboundmedicine.com/medline/citation/20693151/Concurrent_comparison_of_epidemiology_clinical_presentation_and_outcome_between_adult_patients_suffering_from_the_pandemic_influenza_A__H1N1__2009_virus_and_the_seasonal_influenza_A_virus_infection_ L2 - http://pmj.bmj.com/cgi/pmidlookup?view=long&amp;pmid=20693151 DB - PRIME DP - Unbound Medicine ER -