Tags

Type your tag names separated by a space and hit enter

A prospective study on dietary acrylamide intake and the risk for breast, endometrial, and ovarian cancers.
Cancer Epidemiol Biomarkers Prev 2010; 19(10):2503-15CE

Abstract

BACKGROUND

Acrylamide is a probable human carcinogen formed during cooking of many common foods. Epidemiologic studies on acrylamide and breast cancer risk have been null; however, positive associations with ovarian and endometrial cancers have been reported. We studied acrylamide intake and risk for breast, endometrial, and ovarian cancers in a prospective cohort study.

METHODS

We assessed acrylamide intake among 88,672 women in the Nurses' Health Study using food frequency questionnaires administered every 4 years. Between 1980 and 2006, we identified 6,301 cases of invasive breast cancer, 484 cases of invasive endometrial adenocarcinoma, and 416 cases of epithelial ovarian cancer. We used Cox proportional hazards models to study the association between acrylamide and cancer risk.

RESULTS

We found no association between acrylamide intake and breast cancer overall or according to estrogen and progesterone receptor status. We found an increased risk for endometrial cancer among high acrylamide consumers (adjusted relative risk for highest versus lowest quintile = 1.41; 95% CI, 1.01-1.97; P for trend = 0.03). We observed a nonsignificant suggestion of increased risk for ovarian cancer overall (relative risk, 1.25; 95% CI, 0.88-1.77; P trend = 0.12), with a significantly increased risk for serous tumors (relative risk, 1.58; 95% CI, 0.99-2.52; P trend = 0.04). Associations did not differ by smoking status.

CONCLUSIONS

We observed no association between acrylamide and breast cancer. Risk for endometrial cancer and possibly ovarian cancer was greater among high acrylamide consumers.

IMPACT

This is the second prospective study to report positive associations with endometrial and ovarian cancers. These associations should be further evaluated to inform public health policy.

Authors+Show Affiliations

Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. kwilson@hsph.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

20693310

Citation

Wilson, Kathryn M., et al. "A Prospective Study On Dietary Acrylamide Intake and the Risk for Breast, Endometrial, and Ovarian Cancers." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 19, no. 10, 2010, pp. 2503-15.
Wilson KM, Mucci LA, Rosner BA, et al. A prospective study on dietary acrylamide intake and the risk for breast, endometrial, and ovarian cancers. Cancer Epidemiol Biomarkers Prev. 2010;19(10):2503-15.
Wilson, K. M., Mucci, L. A., Rosner, B. A., & Willett, W. C. (2010). A prospective study on dietary acrylamide intake and the risk for breast, endometrial, and ovarian cancers. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 19(10), pp. 2503-15. doi:10.1158/1055-9965.EPI-10-0391.
Wilson KM, et al. A Prospective Study On Dietary Acrylamide Intake and the Risk for Breast, Endometrial, and Ovarian Cancers. Cancer Epidemiol Biomarkers Prev. 2010;19(10):2503-15. PubMed PMID: 20693310.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A prospective study on dietary acrylamide intake and the risk for breast, endometrial, and ovarian cancers. AU - Wilson,Kathryn M, AU - Mucci,Lorelei A, AU - Rosner,Bernard A, AU - Willett,Walter C, Y1 - 2010/08/06/ PY - 2010/8/10/entrez PY - 2010/8/10/pubmed PY - 2011/2/23/medline SP - 2503 EP - 15 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 19 IS - 10 N2 - BACKGROUND: Acrylamide is a probable human carcinogen formed during cooking of many common foods. Epidemiologic studies on acrylamide and breast cancer risk have been null; however, positive associations with ovarian and endometrial cancers have been reported. We studied acrylamide intake and risk for breast, endometrial, and ovarian cancers in a prospective cohort study. METHODS: We assessed acrylamide intake among 88,672 women in the Nurses' Health Study using food frequency questionnaires administered every 4 years. Between 1980 and 2006, we identified 6,301 cases of invasive breast cancer, 484 cases of invasive endometrial adenocarcinoma, and 416 cases of epithelial ovarian cancer. We used Cox proportional hazards models to study the association between acrylamide and cancer risk. RESULTS: We found no association between acrylamide intake and breast cancer overall or according to estrogen and progesterone receptor status. We found an increased risk for endometrial cancer among high acrylamide consumers (adjusted relative risk for highest versus lowest quintile = 1.41; 95% CI, 1.01-1.97; P for trend = 0.03). We observed a nonsignificant suggestion of increased risk for ovarian cancer overall (relative risk, 1.25; 95% CI, 0.88-1.77; P trend = 0.12), with a significantly increased risk for serous tumors (relative risk, 1.58; 95% CI, 0.99-2.52; P trend = 0.04). Associations did not differ by smoking status. CONCLUSIONS: We observed no association between acrylamide and breast cancer. Risk for endometrial cancer and possibly ovarian cancer was greater among high acrylamide consumers. IMPACT: This is the second prospective study to report positive associations with endometrial and ovarian cancers. These associations should be further evaluated to inform public health policy. SN - 1538-7755 UR - https://www.unboundmedicine.com/medline/citation/20693310/A_prospective_study_on_dietary_acrylamide_intake_and_the_risk_for_breast_endometrial_and_ovarian_cancers_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=20693310 DB - PRIME DP - Unbound Medicine ER -