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Potential risk factors associated with subtypes of uterine leiomyomata.

Abstract

OBJECTIVE

To compare potential risk factors for uterine leiomyomata (UL) subtypes among premenopausal African American and Caucasian women.

METHODS

This cross-sectional study included 986 premenopausal women, aged 35 to 49 years old, from the National Institute of Environmental Health Sciences (NIEHS) Uterine Fibroid Study (UFS). Uterine leiomyomata were subtyped as submucosal, intramural/subserosal, and diffuse, based on ultrasound examinations.

RESULTS

For both ethnic groups, age, age at menarche, body mass index, and current physical activity had similar associations across the 3 UL subtypes. Inverse associations with pregnancies after age 24 appeared to be stronger for the submucosal subtype. Current smoking was associated only with diffuse UL (adjusted odds ratio [aOR] = 1.97, 95% CI: 1.11, 3.51 in African Americans, aOR = 3.00, 95% CI: 1.07, 8.38 in Caucasians).

CONCLUSIONS

Although the 2 focal UL subtypes had similar risk factor profiles, the diffuse UL subtype appeared to have a distinctive risk profile with regard to current smoking. Further study of the diffuse heterogeneity seen with uterine ultrasound is needed.

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  • Authors+Show Affiliations

    ,

    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. dragomir@email.unc.edu

    , , , , ,

    Source

    MeSH

    Adult
    African Americans
    Cross-Sectional Studies
    District of Columbia
    European Continental Ancestry Group
    Female
    Humans
    Leiomyoma
    Middle Aged
    Premenopause
    Risk Factors
    Ultrasonography
    Uterine Neoplasms

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Intramural

    Language

    eng

    PubMed ID

    20693498

    Citation

    Dragomir, Anca D., et al. "Potential Risk Factors Associated With Subtypes of Uterine Leiomyomata." Reproductive Sciences (Thousand Oaks, Calif.), vol. 17, no. 11, 2010, pp. 1029-35.
    Dragomir AD, Schroeder JC, Connolly A, et al. Potential risk factors associated with subtypes of uterine leiomyomata. Reprod Sci. 2010;17(11):1029-35.
    Dragomir, A. D., Schroeder, J. C., Connolly, A., Kupper, L. L., Hill, M. C., Olshan, A. F., & Baird, D. D. (2010). Potential risk factors associated with subtypes of uterine leiomyomata. Reproductive Sciences (Thousand Oaks, Calif.), 17(11), pp. 1029-35. doi:10.1177/1933719110376979.
    Dragomir AD, et al. Potential Risk Factors Associated With Subtypes of Uterine Leiomyomata. Reprod Sci. 2010;17(11):1029-35. PubMed PMID: 20693498.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Potential risk factors associated with subtypes of uterine leiomyomata. AU - Dragomir,Anca D, AU - Schroeder,Jane C, AU - Connolly,AnnaMarie, AU - Kupper,Larry L, AU - Hill,Michael C, AU - Olshan,Andrew F, AU - Baird,Donna D, Y1 - 2010/08/06/ PY - 2010/8/10/entrez PY - 2010/8/10/pubmed PY - 2011/2/16/medline SP - 1029 EP - 35 JF - Reproductive sciences (Thousand Oaks, Calif.) JO - Reprod Sci VL - 17 IS - 11 N2 - OBJECTIVE: To compare potential risk factors for uterine leiomyomata (UL) subtypes among premenopausal African American and Caucasian women. METHODS: This cross-sectional study included 986 premenopausal women, aged 35 to 49 years old, from the National Institute of Environmental Health Sciences (NIEHS) Uterine Fibroid Study (UFS). Uterine leiomyomata were subtyped as submucosal, intramural/subserosal, and diffuse, based on ultrasound examinations. RESULTS: For both ethnic groups, age, age at menarche, body mass index, and current physical activity had similar associations across the 3 UL subtypes. Inverse associations with pregnancies after age 24 appeared to be stronger for the submucosal subtype. Current smoking was associated only with diffuse UL (adjusted odds ratio [aOR] = 1.97, 95% CI: 1.11, 3.51 in African Americans, aOR = 3.00, 95% CI: 1.07, 8.38 in Caucasians). CONCLUSIONS: Although the 2 focal UL subtypes had similar risk factor profiles, the diffuse UL subtype appeared to have a distinctive risk profile with regard to current smoking. Further study of the diffuse heterogeneity seen with uterine ultrasound is needed. SN - 1933-7205 UR - https://www.unboundmedicine.com/medline/citation/20693498/Potential_risk_factors_associated_with_subtypes_of_uterine_leiomyomata_ L2 - http://journals.sagepub.com/doi/full/10.1177/1933719110376979?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -