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Effect of APOE ε4 allele on cortical thicknesses and volumes: the AddNeuroMed study.
J Alzheimers Dis 2010; 21(3):947-66JA

Abstract

The apolipoprotein E (APOE) ε4 allele is a risk factor for Alzheimer's disease (AD), but its effect on brain volumes is controversial. We explored the effect of the ε4 allele on regional cortical thickness and volume measurements using an automated pipeline in 111 subjects with mild cognitive impairment (MCI), 115 AD patients, and 107 age-matched healthy controls. The clinical data were used as covariates in the thickness and volume comparisons. The ε4 carriers had significantly smaller volume than non-carriers in caudate (p=0.028) in controls; in amygdala and caudate in the MCI group (p <or= 0.049); and in hippocampus and amygdala in the AD group (p <or= 0.001). In the female subjects, the ε4 carriers had significantly thinner cortical thickness or smaller volume than non-carriers in medial orbitofrontal gyrus and caudate in controls (p <or= 0.014); in amygdala in MCI subjects (p=0.047) and in hippocampus and amygdala in AD patients (p <or= 0.024). However, in the male subjects, there were significant differences in cortical thickness and volume between ε4 carriers and non-carriers in several structures in the MCI group, but no differences in the controls and AD patients. Compared to the non-carriers, the homozygous ε4 carriers showed significant volume loss in hippocampus, deep nuclei, and caudal anterior cingulate cortex in MCI. In the AD group, the homozygous ε4 carriers had significant volume loss in hippocampus and amygdala. We conclude that the APOE ε4 allele modulates regional cortical thickness and volume in relation to diagnostic group and gender. The ε4 allele has a dose-dependent and regionally specific effect on brain structures.

Authors+Show Affiliations

Department of Neurology, University of Eastern Finland, Kuopio University Hospital, Kuopio, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20693633

Citation

Liu, Yawu, et al. "Effect of APOE Ε4 Allele On Cortical Thicknesses and Volumes: the AddNeuroMed Study." Journal of Alzheimer's Disease : JAD, vol. 21, no. 3, 2010, pp. 947-66.
Liu Y, Paajanen T, Westman E, et al. Effect of APOE ε4 allele on cortical thicknesses and volumes: the AddNeuroMed study. J Alzheimers Dis. 2010;21(3):947-66.
Liu, Y., Paajanen, T., Westman, E., Wahlund, L. O., Simmons, A., Tunnard, C., ... Soininen, H. (2010). Effect of APOE ε4 allele on cortical thicknesses and volumes: the AddNeuroMed study. Journal of Alzheimer's Disease : JAD, 21(3), pp. 947-66. doi:10.3233/JAD-2010-100201.
Liu Y, et al. Effect of APOE Ε4 Allele On Cortical Thicknesses and Volumes: the AddNeuroMed Study. J Alzheimers Dis. 2010;21(3):947-66. PubMed PMID: 20693633.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of APOE ε4 allele on cortical thicknesses and volumes: the AddNeuroMed study. AU - Liu,Yawu, AU - Paajanen,Teemu, AU - Westman,Eric, AU - Wahlund,Lars-Olof, AU - Simmons,Andrew, AU - Tunnard,Catherine, AU - Sobow,Tomasz, AU - Proitsi,Petroula, AU - Powell,John, AU - Mecocci,Patrizia, AU - Tsolaki,Magda, AU - Vellas,Bruno, AU - Muehlboeck,Sebastian, AU - Evans,Alan, AU - Spenger,Christian, AU - Lovestone,Simon, AU - Soininen,Hilkka, AU - ,, PY - 2010/8/10/entrez PY - 2010/8/10/pubmed PY - 2011/1/19/medline SP - 947 EP - 66 JF - Journal of Alzheimer's disease : JAD JO - J. Alzheimers Dis. VL - 21 IS - 3 N2 - The apolipoprotein E (APOE) ε4 allele is a risk factor for Alzheimer's disease (AD), but its effect on brain volumes is controversial. We explored the effect of the ε4 allele on regional cortical thickness and volume measurements using an automated pipeline in 111 subjects with mild cognitive impairment (MCI), 115 AD patients, and 107 age-matched healthy controls. The clinical data were used as covariates in the thickness and volume comparisons. The ε4 carriers had significantly smaller volume than non-carriers in caudate (p=0.028) in controls; in amygdala and caudate in the MCI group (p <or= 0.049); and in hippocampus and amygdala in the AD group (p <or= 0.001). In the female subjects, the ε4 carriers had significantly thinner cortical thickness or smaller volume than non-carriers in medial orbitofrontal gyrus and caudate in controls (p <or= 0.014); in amygdala in MCI subjects (p=0.047) and in hippocampus and amygdala in AD patients (p <or= 0.024). However, in the male subjects, there were significant differences in cortical thickness and volume between ε4 carriers and non-carriers in several structures in the MCI group, but no differences in the controls and AD patients. Compared to the non-carriers, the homozygous ε4 carriers showed significant volume loss in hippocampus, deep nuclei, and caudal anterior cingulate cortex in MCI. In the AD group, the homozygous ε4 carriers had significant volume loss in hippocampus and amygdala. We conclude that the APOE ε4 allele modulates regional cortical thickness and volume in relation to diagnostic group and gender. The ε4 allele has a dose-dependent and regionally specific effect on brain structures. SN - 1875-8908 UR - https://www.unboundmedicine.com/medline/citation/20693633/Effect_of_APOE_ε4_allele_on_cortical_thicknesses_and_volumes:_the_AddNeuroMed_study_ L2 - https://content.iospress.com/openurl?genre=article&amp;id=doi:10.3233/JAD-2010-100201 DB - PRIME DP - Unbound Medicine ER -