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Characteristics of autochthonous hepatitis E virus infection in solid-organ transplant recipients in France.
J Infect Dis. 2010 Sep 15; 202(6):835-44.JI

Abstract

BACKGROUND

Hepatitis E virus (HEV) infections can lead to chronic hepatitis in immunocompromised patients. We have investigated the risk factors for HEV infection among solid-organ transplant recipients and the characteristics of these infections.

METHODS

We performed serological tests, quantified the virus, and genotyped the virus in plasma samples. We performed a case-control study with HEV-infected patients and control participants matched for sex and age who were recruited from a population of solid-organ transplant recipients with no markers of HEV infection.

RESULTS

We investigated 38 consecutive cases of HEV genotype 3 infection. Twenty-two (58%) of these 38 patients developed a chronic infection. The acute-phase aminotransferase levels were higher in the patients who cleared the virus than in those who developed chronic infections. The anti-HEV immunoglobulin G and immunoglobulin M profiles and HEV RNA concentration in patients who cleared the virus were similar to those in patients who developed a chronic infection. A logistic regression analysis of 37 case patients and 148 control participants indicated that the only factor independently associated with HEV infection was the consumption of game meat (68% of case patients vs 47% of control participants; odds ratio, 2.32; 95% confidence interval, 1.04-5.15).

CONCLUSION

Immunocompromised patients should avoid eating insufficiently cooked game meat or pork products so as to reduce the risk of HEV infection and chronic liver disease.

Authors+Show Affiliations

Institut National de la Santé et de la Recherche Médicale Unité 563, Centre de Physiopathologie de Toulouse Purpan, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20695798

Citation

Legrand-Abravanel, Florence, et al. "Characteristics of Autochthonous Hepatitis E Virus Infection in Solid-organ Transplant Recipients in France." The Journal of Infectious Diseases, vol. 202, no. 6, 2010, pp. 835-44.
Legrand-Abravanel F, Kamar N, Sandres-Saune K, et al. Characteristics of autochthonous hepatitis E virus infection in solid-organ transplant recipients in France. J Infect Dis. 2010;202(6):835-44.
Legrand-Abravanel, F., Kamar, N., Sandres-Saune, K., Garrouste, C., Dubois, M., Mansuy, J. M., Muscari, F., Sallusto, F., Rostaing, L., & Izopet, J. (2010). Characteristics of autochthonous hepatitis E virus infection in solid-organ transplant recipients in France. The Journal of Infectious Diseases, 202(6), 835-44. https://doi.org/10.1086/655899
Legrand-Abravanel F, et al. Characteristics of Autochthonous Hepatitis E Virus Infection in Solid-organ Transplant Recipients in France. J Infect Dis. 2010 Sep 15;202(6):835-44. PubMed PMID: 20695798.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characteristics of autochthonous hepatitis E virus infection in solid-organ transplant recipients in France. AU - Legrand-Abravanel,Florence, AU - Kamar,Nassim, AU - Sandres-Saune,Karine, AU - Garrouste,Cyril, AU - Dubois,Martine, AU - Mansuy,Jean-Michel, AU - Muscari,Fabrice, AU - Sallusto,Federico, AU - Rostaing,Lionel, AU - Izopet,Jacques, PY - 2010/8/11/entrez PY - 2010/8/11/pubmed PY - 2010/9/10/medline SP - 835 EP - 44 JF - The Journal of infectious diseases JO - J Infect Dis VL - 202 IS - 6 N2 - BACKGROUND: Hepatitis E virus (HEV) infections can lead to chronic hepatitis in immunocompromised patients. We have investigated the risk factors for HEV infection among solid-organ transplant recipients and the characteristics of these infections. METHODS: We performed serological tests, quantified the virus, and genotyped the virus in plasma samples. We performed a case-control study with HEV-infected patients and control participants matched for sex and age who were recruited from a population of solid-organ transplant recipients with no markers of HEV infection. RESULTS: We investigated 38 consecutive cases of HEV genotype 3 infection. Twenty-two (58%) of these 38 patients developed a chronic infection. The acute-phase aminotransferase levels were higher in the patients who cleared the virus than in those who developed chronic infections. The anti-HEV immunoglobulin G and immunoglobulin M profiles and HEV RNA concentration in patients who cleared the virus were similar to those in patients who developed a chronic infection. A logistic regression analysis of 37 case patients and 148 control participants indicated that the only factor independently associated with HEV infection was the consumption of game meat (68% of case patients vs 47% of control participants; odds ratio, 2.32; 95% confidence interval, 1.04-5.15). CONCLUSION: Immunocompromised patients should avoid eating insufficiently cooked game meat or pork products so as to reduce the risk of HEV infection and chronic liver disease. SN - 1537-6613 UR - https://www.unboundmedicine.com/medline/citation/20695798/Characteristics_of_autochthonous_hepatitis_E_virus_infection_in_solid_organ_transplant_recipients_in_France_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1086/655899 DB - PRIME DP - Unbound Medicine ER -