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Waist circumference and all-cause mortality in a large US cohort.
Arch Intern Med. 2010 Aug 09; 170(15):1293-301.AI

Abstract

BACKGROUND

Waist circumference (WC), a measure of abdominal obesity, is associated with higher mortality independent of body mass index (BMI). Less is known about the association between WC and mortality within categories of BMI or for the very high levels of WC that are now common.

METHODS

We examined the association between WC and mortality among 48,500 men and 56,343 women, 50 years or older, in the Cancer Prevention Study II Nutrition Cohort. A total of 9315 men and 5332 women died between 1997 and the end of follow-up in 2006.

RESULTS

After adjustment for BMI and other risk factors, very high levels of WC were associated with an approximately 2-fold higher risk of mortality in men and women (among men, relative risk [RR]=2.02; 95% confidence interval [CI], 1.71-2.39 for WC>or=120 cm compared with <90 cm; among women, RR=2.36; 95% CI, 1.98-2.82 for WC>or=110 cm compared with <75 cm). The WC was positively associated with mortality within all categories of BMI. In men, a 10-cm increase in WC was associated with RRs of 1.16 (95% CI, 1.09-1.23), 1.18 (95% CI, 1.12-1.24), and 1.21 (95% CI, 1.13-1.30) within normal (18.5 to <25), overweight (25 to <30), and obese (>or=30) BMI categories, respectively. In women, corresponding RRs were 1.25 (95% CI, 1.18-1.32), 1.15 (95% CI, 1.08-1.22), and 1.13 (95% CI, 1.06-1.20).

CONCLUSION

These results emphasize the importance of WC as a risk factor for mortality in older adults, regardless of BMI.

Authors+Show Affiliations

Epidemiology Research Program, American Cancer Society, 250 Williams St, Atlanta, GA 30303-1002, USA. eric.jacobs@cancer.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

20696950

Citation

Jacobs, Eric J., et al. "Waist Circumference and All-cause Mortality in a Large US Cohort." Archives of Internal Medicine, vol. 170, no. 15, 2010, pp. 1293-301.
Jacobs EJ, Newton CC, Wang Y, et al. Waist circumference and all-cause mortality in a large US cohort. Arch Intern Med. 2010;170(15):1293-301.
Jacobs, E. J., Newton, C. C., Wang, Y., Patel, A. V., McCullough, M. L., Campbell, P. T., Thun, M. J., & Gapstur, S. M. (2010). Waist circumference and all-cause mortality in a large US cohort. Archives of Internal Medicine, 170(15), 1293-301. https://doi.org/10.1001/archinternmed.2010.201
Jacobs EJ, et al. Waist Circumference and All-cause Mortality in a Large US Cohort. Arch Intern Med. 2010 Aug 9;170(15):1293-301. PubMed PMID: 20696950.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Waist circumference and all-cause mortality in a large US cohort. AU - Jacobs,Eric J, AU - Newton,Christina C, AU - Wang,Yiting, AU - Patel,Alpa V, AU - McCullough,Marjorie L, AU - Campbell,Peter T, AU - Thun,Michael J, AU - Gapstur,Susan M, PY - 2010/8/11/entrez PY - 2010/8/11/pubmed PY - 2010/9/2/medline SP - 1293 EP - 301 JF - Archives of internal medicine JO - Arch Intern Med VL - 170 IS - 15 N2 - BACKGROUND: Waist circumference (WC), a measure of abdominal obesity, is associated with higher mortality independent of body mass index (BMI). Less is known about the association between WC and mortality within categories of BMI or for the very high levels of WC that are now common. METHODS: We examined the association between WC and mortality among 48,500 men and 56,343 women, 50 years or older, in the Cancer Prevention Study II Nutrition Cohort. A total of 9315 men and 5332 women died between 1997 and the end of follow-up in 2006. RESULTS: After adjustment for BMI and other risk factors, very high levels of WC were associated with an approximately 2-fold higher risk of mortality in men and women (among men, relative risk [RR]=2.02; 95% confidence interval [CI], 1.71-2.39 for WC>or=120 cm compared with <90 cm; among women, RR=2.36; 95% CI, 1.98-2.82 for WC>or=110 cm compared with <75 cm). The WC was positively associated with mortality within all categories of BMI. In men, a 10-cm increase in WC was associated with RRs of 1.16 (95% CI, 1.09-1.23), 1.18 (95% CI, 1.12-1.24), and 1.21 (95% CI, 1.13-1.30) within normal (18.5 to <25), overweight (25 to <30), and obese (>or=30) BMI categories, respectively. In women, corresponding RRs were 1.25 (95% CI, 1.18-1.32), 1.15 (95% CI, 1.08-1.22), and 1.13 (95% CI, 1.06-1.20). CONCLUSION: These results emphasize the importance of WC as a risk factor for mortality in older adults, regardless of BMI. SN - 1538-3679 UR - https://www.unboundmedicine.com/medline/citation/20696950/Waist_circumference_and_all_cause_mortality_in_a_large_US_cohort_ L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/10.1001/archinternmed.2010.201 DB - PRIME DP - Unbound Medicine ER -