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Micronutrient intake and breast cancer characteristics among postmenopausal women.

Abstract

Few studies on micronutrients and postmenopausal breast cancer have examined the association with breast cancer characteristics. The aim of this study was to investigate the associations between vitamin C, vitamin E, folate and beta-carotene from diet and supplements and risk of postmenopausal breast cancer subtypes defined by histology (ductal/lobular), estrogen receptor (ER) and progesterone receptor (PGR) status. In a prospective cohort study of 26,224 postmenopausal women information on diet, supplements and lifestyle was collected through questionnaires. One thousand seventy-two cases were identified during follow-up. Incidence rate ratios of total breast cancers and breast cancer subtypes related to micronutrient intake were calculated using Cox proportional hazard analyses. This study found no association between overall breast cancer and any micronutrients, while some effects were shown when stratifying by breast cancer subtypes: dietary but not supplemental beta-carotene showed a protective effect against lobular breast cancer [incidence rate ratio (IRR): 0.72; 95% confidence interval (CI): 0.57-0.91]. Dietary vitamin E was associated with decreased risk of ER and PGR positive breast cancer (IRR: 0.50; 95% CI: 0.25-0.98) and dietary folate was associated with increased risk of ER and PGR positive breast cancer (IRR: 1.27; 95% CI: 1.03-1.95). This study found no effect of micronutrients on overall risk of postmenopausal breast cancer, but indicated possible effects of micronutrients in subgroups of breast cancer, with a potential beneficial effect of dietary beta-carotene in lobular breast cancer and dietary vitamin E in ER + PGR+ breast cancer and a potential harmful effect of dietary folate in ER+ PGR+ breast cancer.

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  • Authors+Show Affiliations

    ,

    Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden 49, DK-2100 Copenhagen Ø, Denmark. roswall@cancer.dk

    , , , ,

    Source

    MeSH

    Ascorbic Acid
    Breast Neoplasms
    Diet
    Dietary Supplements
    Female
    Folic Acid
    Follow-Up Studies
    Humans
    Micronutrients
    Middle Aged
    Neoplasm Proteins
    Postmenopause
    Prospective Studies
    Receptors, Estrogen
    Receptors, Progesterone
    Risk
    Surveys and Questionnaires
    Vitamin E
    beta Carotene

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    20698054

    Citation

    Roswall, Nina, et al. "Micronutrient Intake and Breast Cancer Characteristics Among Postmenopausal Women." European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP), vol. 19, no. 5, 2010, pp. 360-5.
    Roswall N, Olsen A, Christensen J, et al. Micronutrient intake and breast cancer characteristics among postmenopausal women. Eur J Cancer Prev. 2010;19(5):360-5.
    Roswall, N., Olsen, A., Christensen, J., Dragsted, L. O., Overvad, K., & Tjønneland, A. (2010). Micronutrient intake and breast cancer characteristics among postmenopausal women. European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP), 19(5), pp. 360-5.
    Roswall N, et al. Micronutrient Intake and Breast Cancer Characteristics Among Postmenopausal Women. Eur J Cancer Prev. 2010;19(5):360-5. PubMed PMID: 20698054.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Micronutrient intake and breast cancer characteristics among postmenopausal women. AU - Roswall,Nina, AU - Olsen,Anja, AU - Christensen,Jane, AU - Dragsted,Lars O, AU - Overvad,Kim, AU - Tjønneland,Anne, PY - 2010/8/11/entrez PY - 2010/8/11/pubmed PY - 2010/11/9/medline SP - 360 EP - 5 JF - European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) JO - Eur. J. Cancer Prev. VL - 19 IS - 5 N2 - Few studies on micronutrients and postmenopausal breast cancer have examined the association with breast cancer characteristics. The aim of this study was to investigate the associations between vitamin C, vitamin E, folate and beta-carotene from diet and supplements and risk of postmenopausal breast cancer subtypes defined by histology (ductal/lobular), estrogen receptor (ER) and progesterone receptor (PGR) status. In a prospective cohort study of 26,224 postmenopausal women information on diet, supplements and lifestyle was collected through questionnaires. One thousand seventy-two cases were identified during follow-up. Incidence rate ratios of total breast cancers and breast cancer subtypes related to micronutrient intake were calculated using Cox proportional hazard analyses. This study found no association between overall breast cancer and any micronutrients, while some effects were shown when stratifying by breast cancer subtypes: dietary but not supplemental beta-carotene showed a protective effect against lobular breast cancer [incidence rate ratio (IRR): 0.72; 95% confidence interval (CI): 0.57-0.91]. Dietary vitamin E was associated with decreased risk of ER and PGR positive breast cancer (IRR: 0.50; 95% CI: 0.25-0.98) and dietary folate was associated with increased risk of ER and PGR positive breast cancer (IRR: 1.27; 95% CI: 1.03-1.95). This study found no effect of micronutrients on overall risk of postmenopausal breast cancer, but indicated possible effects of micronutrients in subgroups of breast cancer, with a potential beneficial effect of dietary beta-carotene in lobular breast cancer and dietary vitamin E in ER + PGR+ breast cancer and a potential harmful effect of dietary folate in ER+ PGR+ breast cancer. SN - 1473-5709 UR - https://www.unboundmedicine.com/medline/citation/20698054/Micronutrient_intake_and_breast_cancer_characteristics_among_postmenopausal_women_ L2 - http://Insights.ovid.com/pubmed?pmid=20698054 DB - PRIME DP - Unbound Medicine ER -