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Alcohol and tobacco use in relation to gastric cancer: a prospective study of men in Shanghai, China.
Cancer Epidemiol Biomarkers Prev 2010; 19(9):2287-97CE

Abstract

BACKGROUND

Epidemiologic findings of tobacco and alcohol use in relation to gastric cancer are inconsistent. Well-designed prospective studies examining their relationship are sparse.

METHODS

The association between cigarette smoking/alcohol intake and gastric cancer risk was examined in a population-based prospective cohort of 18,244 middle-aged and older men in Shanghai, China, who were enrolled in the study during 1986-1989. After up to 20 years of follow-up, 391 incident gastric cancer cases were identified. Cox proportional hazards regression models were used to estimate hazard ratios (HR) and corresponding 95% confidence intervals (95% CI).

RESULTS

Ever smokers experienced a statistically significant increased risk of gastric cancer (HR, 1.59; 95% CI, 1.27-1.99) compared with nonsmokers after adjustment for alcohol intake and other confounders. Among nondrinkers, smokers experienced 80% increased risk of gastric cancer (HR, 1.81; 95% CI,1.36, 2.41). Conversely, heavy drinkers experienced a statistically significant increase in risk of gastric cancer (HR, 1.46; 95% CI, 1.05-2.04) among all subjects and a statistically nonsignificant 80% increased risk among never smokers. Further adjustment for Helicobacter pylori serology, serum levels of beta-carotene and vitamin C, and urinary level of total isothiocyanates in combination with glutathione S-transferase (GST) M1 and GSTT1 genotypes did not materially change the associations between smoking/alcohol consumption and gastric cancer risk.

CONCLUSIONS

These results suggest that cigarette smoking and alcohol consumption may exert independent effects on the development of gastric cancer in this high-risk population.

IMPACT

Modification of these lifestyle choices may reduce the incidence of gastric cancer.

Authors+Show Affiliations

Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Masonic Cancer Center, Minneapolis, Minnesota 55455, USA. moyx0022@umn.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

20699372

Citation

Moy, Kristin A., et al. "Alcohol and Tobacco Use in Relation to Gastric Cancer: a Prospective Study of Men in Shanghai, China." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 19, no. 9, 2010, pp. 2287-97.
Moy KA, Fan Y, Wang R, et al. Alcohol and tobacco use in relation to gastric cancer: a prospective study of men in Shanghai, China. Cancer Epidemiol Biomarkers Prev. 2010;19(9):2287-97.
Moy, K. A., Fan, Y., Wang, R., Gao, Y. T., Yu, M. C., & Yuan, J. M. (2010). Alcohol and tobacco use in relation to gastric cancer: a prospective study of men in Shanghai, China. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 19(9), pp. 2287-97. doi:10.1158/1055-9965.EPI-10-0362.
Moy KA, et al. Alcohol and Tobacco Use in Relation to Gastric Cancer: a Prospective Study of Men in Shanghai, China. Cancer Epidemiol Biomarkers Prev. 2010;19(9):2287-97. PubMed PMID: 20699372.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol and tobacco use in relation to gastric cancer: a prospective study of men in Shanghai, China. AU - Moy,Kristin A, AU - Fan,Yunhua, AU - Wang,Renwei, AU - Gao,Yu-Tang, AU - Yu,Mimi C, AU - Yuan,Jian-Min, Y1 - 2010/08/10/ PY - 2010/8/12/entrez PY - 2010/8/12/pubmed PY - 2011/2/9/medline SP - 2287 EP - 97 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 19 IS - 9 N2 - BACKGROUND: Epidemiologic findings of tobacco and alcohol use in relation to gastric cancer are inconsistent. Well-designed prospective studies examining their relationship are sparse. METHODS: The association between cigarette smoking/alcohol intake and gastric cancer risk was examined in a population-based prospective cohort of 18,244 middle-aged and older men in Shanghai, China, who were enrolled in the study during 1986-1989. After up to 20 years of follow-up, 391 incident gastric cancer cases were identified. Cox proportional hazards regression models were used to estimate hazard ratios (HR) and corresponding 95% confidence intervals (95% CI). RESULTS: Ever smokers experienced a statistically significant increased risk of gastric cancer (HR, 1.59; 95% CI, 1.27-1.99) compared with nonsmokers after adjustment for alcohol intake and other confounders. Among nondrinkers, smokers experienced 80% increased risk of gastric cancer (HR, 1.81; 95% CI,1.36, 2.41). Conversely, heavy drinkers experienced a statistically significant increase in risk of gastric cancer (HR, 1.46; 95% CI, 1.05-2.04) among all subjects and a statistically nonsignificant 80% increased risk among never smokers. Further adjustment for Helicobacter pylori serology, serum levels of beta-carotene and vitamin C, and urinary level of total isothiocyanates in combination with glutathione S-transferase (GST) M1 and GSTT1 genotypes did not materially change the associations between smoking/alcohol consumption and gastric cancer risk. CONCLUSIONS: These results suggest that cigarette smoking and alcohol consumption may exert independent effects on the development of gastric cancer in this high-risk population. IMPACT: Modification of these lifestyle choices may reduce the incidence of gastric cancer. SN - 1538-7755 UR - https://www.unboundmedicine.com/medline/citation/20699372/Alcohol_and_tobacco_use_in_relation_to_gastric_cancer:_a_prospective_study_of_men_in_Shanghai_China_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=20699372 DB - PRIME DP - Unbound Medicine ER -