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Differing effect of modifiable cardiovascular risk factors on intima-media thickening and plaque formation at different sites of the arterial vasculature.
Heart 2010; 96(19):1579-85H

Abstract

OBJECTIVE

The effects of cardiovascular risk factors on the vascular anatomy at differing sites of the arterial vasculature have not been well described. The aim of this study was to compare the effect of cardiovascular risk factors on the intima media thickness (IMT) of the wall of the right and left common carotid artery (CCA) at their bifurcation and proximal from their bifurcation, and the effects on the presence of plaque at carotid and femoral arteries.

DESIGN

Cross-sectional population-based study.

SETTING/PARTICIPANTS

Random samples of men (n=425) and women (n=367) aged 56-77 years were recruited from two general practices participating in the British Regional Heart Study.

MAIN OUTCOME MEASURES

Ultrasound examination ascertained IMT and the presence of atheromatous plaque. A model for correlated outcomes was used to simultaneously model all risk factor on all measured vascular sites.

RESULTS

All cardiovascular risk factors (HbA(1c), waist-to-hip ratio, hypertension, LDL and smoking) showed a larger association with IMT thickening at the wall of the CCA at its bifurcation than proximal to its bifurcation. The IMT was greater on the left wall of the CCA than on the right. The association between hypertension with the wall of the CCA depended on age. Smoking was the only risk factor that demonstrated an increased odds (45%, 95% CI 14% to 65%) of the presence of plaque at the femoral arteries when compared with the CCA.

CONCLUSIONS

The associations of cardiovascular risk factors with the vascular anatomy are not uniform for IMT thickening or the presence of plaque. These differences in local arterial anatomy may result in differences between trial outcomes that investigate surrogate endpoints such as IMT.

Authors+Show Affiliations

Department of Cardiology, The James Black Centre, Kings College London, London SE5 9NU, UK. sanjaychaubey110674@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20702541

Citation

Chaubey, Sanjay, et al. "Differing Effect of Modifiable Cardiovascular Risk Factors On Intima-media Thickening and Plaque Formation at Different Sites of the Arterial Vasculature." Heart (British Cardiac Society), vol. 96, no. 19, 2010, pp. 1579-85.
Chaubey S, Nitsch D, Altmann D, et al. Differing effect of modifiable cardiovascular risk factors on intima-media thickening and plaque formation at different sites of the arterial vasculature. Heart. 2010;96(19):1579-85.
Chaubey, S., Nitsch, D., Altmann, D., & Ebrahim, S. (2010). Differing effect of modifiable cardiovascular risk factors on intima-media thickening and plaque formation at different sites of the arterial vasculature. Heart (British Cardiac Society), 96(19), pp. 1579-85. doi:10.1136/hrt.2009.188219.
Chaubey S, et al. Differing Effect of Modifiable Cardiovascular Risk Factors On Intima-media Thickening and Plaque Formation at Different Sites of the Arterial Vasculature. Heart. 2010;96(19):1579-85. PubMed PMID: 20702541.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differing effect of modifiable cardiovascular risk factors on intima-media thickening and plaque formation at different sites of the arterial vasculature. AU - Chaubey,Sanjay, AU - Nitsch,Dorothea, AU - Altmann,Daniel, AU - Ebrahim,Shah, Y1 - 2010/08/11/ PY - 2010/8/13/entrez PY - 2010/8/13/pubmed PY - 2011/3/15/medline SP - 1579 EP - 85 JF - Heart (British Cardiac Society) JO - Heart VL - 96 IS - 19 N2 - OBJECTIVE: The effects of cardiovascular risk factors on the vascular anatomy at differing sites of the arterial vasculature have not been well described. The aim of this study was to compare the effect of cardiovascular risk factors on the intima media thickness (IMT) of the wall of the right and left common carotid artery (CCA) at their bifurcation and proximal from their bifurcation, and the effects on the presence of plaque at carotid and femoral arteries. DESIGN: Cross-sectional population-based study. SETTING/PARTICIPANTS: Random samples of men (n=425) and women (n=367) aged 56-77 years were recruited from two general practices participating in the British Regional Heart Study. MAIN OUTCOME MEASURES: Ultrasound examination ascertained IMT and the presence of atheromatous plaque. A model for correlated outcomes was used to simultaneously model all risk factor on all measured vascular sites. RESULTS: All cardiovascular risk factors (HbA(1c), waist-to-hip ratio, hypertension, LDL and smoking) showed a larger association with IMT thickening at the wall of the CCA at its bifurcation than proximal to its bifurcation. The IMT was greater on the left wall of the CCA than on the right. The association between hypertension with the wall of the CCA depended on age. Smoking was the only risk factor that demonstrated an increased odds (45%, 95% CI 14% to 65%) of the presence of plaque at the femoral arteries when compared with the CCA. CONCLUSIONS: The associations of cardiovascular risk factors with the vascular anatomy are not uniform for IMT thickening or the presence of plaque. These differences in local arterial anatomy may result in differences between trial outcomes that investigate surrogate endpoints such as IMT. SN - 1468-201X UR - https://www.unboundmedicine.com/medline/citation/20702541/Differing_effect_of_modifiable_cardiovascular_risk_factors_on_intima_media_thickening_and_plaque_formation_at_different_sites_of_the_arterial_vasculature_ L2 - http://heart.bmj.com/cgi/pmidlookup?view=long&pmid=20702541 DB - PRIME DP - Unbound Medicine ER -