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Associations of dietary fat with albuminuria and kidney dysfunction.

Abstract

BACKGROUND

Diet represents a potentially important target for intervention in nephropathy, yet data on this topic are scarce.

OBJECTIVES

The objective was to investigate associations between dietary fats and early kidney disease.

DESIGN

We examined cross-sectional associations between dietary fats and the presence of high albuminuria (an established independent predictor of kidney function decline, cardiovascular disease, and mortality) or estimated glomerular filtration rate (eGFR) <60 mL ⋅ min(-1) ⋅ 1.73 m(-2) at baseline in 19,256 participants of the REGARDS (Reasons for Geographic and Racial Differences in Stroke) study, an ongoing cohort study in US adults aged ≥45 y at time of enrollment. We used logistic regression to assess associations between quintiles of total fat and subtypes of dietary fat (saturated, monounsaturated, polyunsaturated, and trans fat) and presence of high albuminuria or eGFR <60 mL ⋅ min(-1) ⋅ 1.73 m(-2).

RESULTS

After multivariable adjustment, only saturated fat intake was significantly associated with high albuminuria [for quintile 5 compared with quintile 1, odds ratio (OR): 1.33; 95% CI: 1.07, 1.66; P for trend = 0.04]. No significant associations between any type of fat and eGFR <60 mL · min(-1) · 1.73 m(-2) were observed. ORs between the highest quintile of saturated fat and eGFR <60 mL · min(-1) · 1.73 m(-2) varied by race with a borderline significant interaction term (ORs: 1.24 in whites compared with 0.74 in blacks; P for interaction = 0.05) in multivariable-adjusted models, but no other associations were significantly modified by race or diabetes status.

CONCLUSION

Higher saturated fat intake is significantly associated with the presence of high albuminuria, but neither total nor other subtypes of dietary fat are associated with high albuminuria or eGFR <60 mL · min(-1) · 1.73 m(-2).

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    MeSH

    Adult
    African Continental Ancestry Group
    Aged
    Aged, 80 and over
    Albuminuria
    Body Height
    Body Weight
    Cardiovascular Diseases
    Cross-Sectional Studies
    Dietary Fats
    European Continental Ancestry Group
    Female
    Glomerular Filtration Rate
    Humans
    Kidney Diseases
    Male
    Middle Aged
    Odds Ratio
    Patient Selection
    Regression Analysis
    United States

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    20702608

    Citation

    TY - JOUR T1 - Associations of dietary fat with albuminuria and kidney dysfunction. AU - Lin,Julie, AU - Judd,Suzanne, AU - Le,Anh, AU - Ard,Jamy, AU - Newsome,Britt B, AU - Howard,George, AU - Warnock,David G, AU - McClellan,William, Y1 - 2010/08/11/ PY - 2010/8/11/aheadofprint PY - 2010/8/13/entrez PY - 2010/8/13/pubmed PY - 2010/10/28/medline SP - 897 EP - 904 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 92 IS - 4 N2 - BACKGROUND: Diet represents a potentially important target for intervention in nephropathy, yet data on this topic are scarce. OBJECTIVES: The objective was to investigate associations between dietary fats and early kidney disease. DESIGN: We examined cross-sectional associations between dietary fats and the presence of high albuminuria (an established independent predictor of kidney function decline, cardiovascular disease, and mortality) or estimated glomerular filtration rate (eGFR) <60 mL ⋅ min(-1) ⋅ 1.73 m(-2) at baseline in 19,256 participants of the REGARDS (Reasons for Geographic and Racial Differences in Stroke) study, an ongoing cohort study in US adults aged ≥45 y at time of enrollment. We used logistic regression to assess associations between quintiles of total fat and subtypes of dietary fat (saturated, monounsaturated, polyunsaturated, and trans fat) and presence of high albuminuria or eGFR <60 mL ⋅ min(-1) ⋅ 1.73 m(-2). RESULTS: After multivariable adjustment, only saturated fat intake was significantly associated with high albuminuria [for quintile 5 compared with quintile 1, odds ratio (OR): 1.33; 95% CI: 1.07, 1.66; P for trend = 0.04]. No significant associations between any type of fat and eGFR <60 mL · min(-1) · 1.73 m(-2) were observed. ORs between the highest quintile of saturated fat and eGFR <60 mL · min(-1) · 1.73 m(-2) varied by race with a borderline significant interaction term (ORs: 1.24 in whites compared with 0.74 in blacks; P for interaction = 0.05) in multivariable-adjusted models, but no other associations were significantly modified by race or diabetes status. CONCLUSION: Higher saturated fat intake is significantly associated with the presence of high albuminuria, but neither total nor other subtypes of dietary fat are associated with high albuminuria or eGFR <60 mL · min(-1) · 1.73 m(-2). SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/20702608/full_citation L2 - http://www.ajcn.org/cgi/pmidlookup?view=long&amp;pmid=20702608 ER -