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Associations of dietary fat with albuminuria and kidney dysfunction.
Am J Clin Nutr 2010; 92(4):897-904AJ

Abstract

BACKGROUND

Diet represents a potentially important target for intervention in nephropathy, yet data on this topic are scarce.

OBJECTIVES

The objective was to investigate associations between dietary fats and early kidney disease.

DESIGN

We examined cross-sectional associations between dietary fats and the presence of high albuminuria (an established independent predictor of kidney function decline, cardiovascular disease, and mortality) or estimated glomerular filtration rate (eGFR) <60 mL ⋅ min(-1) ⋅ 1.73 m(-2) at baseline in 19,256 participants of the REGARDS (Reasons for Geographic and Racial Differences in Stroke) study, an ongoing cohort study in US adults aged ≥45 y at time of enrollment. We used logistic regression to assess associations between quintiles of total fat and subtypes of dietary fat (saturated, monounsaturated, polyunsaturated, and trans fat) and presence of high albuminuria or eGFR <60 mL ⋅ min(-1) ⋅ 1.73 m(-2).

RESULTS

After multivariable adjustment, only saturated fat intake was significantly associated with high albuminuria [for quintile 5 compared with quintile 1, odds ratio (OR): 1.33; 95% CI: 1.07, 1.66; P for trend = 0.04]. No significant associations between any type of fat and eGFR <60 mL · min(-1) · 1.73 m(-2) were observed. ORs between the highest quintile of saturated fat and eGFR <60 mL · min(-1) · 1.73 m(-2) varied by race with a borderline significant interaction term (ORs: 1.24 in whites compared with 0.74 in blacks; P for interaction = 0.05) in multivariable-adjusted models, but no other associations were significantly modified by race or diabetes status.

CONCLUSION

Higher saturated fat intake is significantly associated with the presence of high albuminuria, but neither total nor other subtypes of dietary fat are associated with high albuminuria or eGFR <60 mL · min(-1) · 1.73 m(-2).

Authors+Show Affiliations

Renal Division, Brigham and Women's Hospital, Boston, MA 02115, USA. jlin11@partners.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20702608

Citation

Lin, Julie, et al. "Associations of Dietary Fat With Albuminuria and Kidney Dysfunction." The American Journal of Clinical Nutrition, vol. 92, no. 4, 2010, pp. 897-904.
Lin J, Judd S, Le A, et al. Associations of dietary fat with albuminuria and kidney dysfunction. Am J Clin Nutr. 2010;92(4):897-904.
Lin, J., Judd, S., Le, A., Ard, J., Newsome, B. B., Howard, G., ... McClellan, W. (2010). Associations of dietary fat with albuminuria and kidney dysfunction. The American Journal of Clinical Nutrition, 92(4), pp. 897-904. doi:10.3945/ajcn.2010.29479.
Lin J, et al. Associations of Dietary Fat With Albuminuria and Kidney Dysfunction. Am J Clin Nutr. 2010;92(4):897-904. PubMed PMID: 20702608.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Associations of dietary fat with albuminuria and kidney dysfunction. AU - Lin,Julie, AU - Judd,Suzanne, AU - Le,Anh, AU - Ard,Jamy, AU - Newsome,Britt B, AU - Howard,George, AU - Warnock,David G, AU - McClellan,William, Y1 - 2010/08/11/ PY - 2010/8/13/entrez PY - 2010/8/13/pubmed PY - 2010/10/28/medline SP - 897 EP - 904 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 92 IS - 4 N2 - BACKGROUND: Diet represents a potentially important target for intervention in nephropathy, yet data on this topic are scarce. OBJECTIVES: The objective was to investigate associations between dietary fats and early kidney disease. DESIGN: We examined cross-sectional associations between dietary fats and the presence of high albuminuria (an established independent predictor of kidney function decline, cardiovascular disease, and mortality) or estimated glomerular filtration rate (eGFR) <60 mL ⋅ min(-1) ⋅ 1.73 m(-2) at baseline in 19,256 participants of the REGARDS (Reasons for Geographic and Racial Differences in Stroke) study, an ongoing cohort study in US adults aged ≥45 y at time of enrollment. We used logistic regression to assess associations between quintiles of total fat and subtypes of dietary fat (saturated, monounsaturated, polyunsaturated, and trans fat) and presence of high albuminuria or eGFR <60 mL ⋅ min(-1) ⋅ 1.73 m(-2). RESULTS: After multivariable adjustment, only saturated fat intake was significantly associated with high albuminuria [for quintile 5 compared with quintile 1, odds ratio (OR): 1.33; 95% CI: 1.07, 1.66; P for trend = 0.04]. No significant associations between any type of fat and eGFR <60 mL · min(-1) · 1.73 m(-2) were observed. ORs between the highest quintile of saturated fat and eGFR <60 mL · min(-1) · 1.73 m(-2) varied by race with a borderline significant interaction term (ORs: 1.24 in whites compared with 0.74 in blacks; P for interaction = 0.05) in multivariable-adjusted models, but no other associations were significantly modified by race or diabetes status. CONCLUSION: Higher saturated fat intake is significantly associated with the presence of high albuminuria, but neither total nor other subtypes of dietary fat are associated with high albuminuria or eGFR <60 mL · min(-1) · 1.73 m(-2). SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/20702608/full_citation L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.2010.29479 DB - PRIME DP - Unbound Medicine ER -