Tags

Type your tag names separated by a space and hit enter

Diclofenac fast-dissolving film: suppression of bitterness by a taste-sensing system.
Drug Dev Ind Pharm. 2011 Mar; 37(3):252-9.DD

Abstract

CONTEXT

The selection of a proper taste-masking agent (TMA) is a critical issue in the development of fast-dissolving films containing bitter drugs.

OBJECTIVE

This work is aimed to evaluate the suppression of the bitter taste of a maltodextrin fast-dissolving film loaded with 13.4 mg sodium diclofenac (DS) by adding TMAs.

METHODS

The films were prepared by casting and drying aqueous mixtures of maltodextrin (DE = 6), glycerin, sorbitan oleate, and DS. Films were characterized in terms of thickness, tensile properties, film disintegration time, and drug dissolution time. The bitterness intensity of DS and the masking effect of TMAs were evaluated by an electronic tongue.

RESULTS

The 'mint' and 'licorice' flavors and sucralose mixture resulted appropriate to mask DS bitterness as confirmed by a panel of volunteers. The addition of these TMAs did not significantly affect the film disintegration time (15-20 seconds) and DS dissolution rate (about 5 minutes).

CONCLUSION

The electronic tongue was allowed to discriminate the effect of the TMA also in the presence of other hydrosoluble constituents of the film. Therefore, because of its simplicity and rapidity, this technique could assist or even replace the sensory evaluation in the development of fast-dissolving films.

Authors+Show Affiliations

Department of Pharmaceutical Sciences, Università degli Studi di Milano, Milan, Italy. francesco.cilurzo@unimi.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20704459

Citation

Cilurzo, Francesco, et al. "Diclofenac Fast-dissolving Film: Suppression of Bitterness By a Taste-sensing System." Drug Development and Industrial Pharmacy, vol. 37, no. 3, 2011, pp. 252-9.
Cilurzo F, Cupone IE, Minghetti P, et al. Diclofenac fast-dissolving film: suppression of bitterness by a taste-sensing system. Drug Dev Ind Pharm. 2011;37(3):252-9.
Cilurzo, F., Cupone, I. E., Minghetti, P., Buratti, S., Gennari, C. G., & Montanari, L. (2011). Diclofenac fast-dissolving film: suppression of bitterness by a taste-sensing system. Drug Development and Industrial Pharmacy, 37(3), 252-9. https://doi.org/10.3109/03639045.2010.505928
Cilurzo F, et al. Diclofenac Fast-dissolving Film: Suppression of Bitterness By a Taste-sensing System. Drug Dev Ind Pharm. 2011;37(3):252-9. PubMed PMID: 20704459.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diclofenac fast-dissolving film: suppression of bitterness by a taste-sensing system. AU - Cilurzo,Francesco, AU - Cupone,Irma Elisa, AU - Minghetti,Paola, AU - Buratti,Susanna, AU - Gennari,Chiara G M, AU - Montanari,Luisa, Y1 - 2010/08/12/ PY - 2010/8/14/entrez PY - 2010/8/14/pubmed PY - 2011/8/4/medline SP - 252 EP - 9 JF - Drug development and industrial pharmacy JO - Drug Dev Ind Pharm VL - 37 IS - 3 N2 - CONTEXT: The selection of a proper taste-masking agent (TMA) is a critical issue in the development of fast-dissolving films containing bitter drugs. OBJECTIVE: This work is aimed to evaluate the suppression of the bitter taste of a maltodextrin fast-dissolving film loaded with 13.4 mg sodium diclofenac (DS) by adding TMAs. METHODS: The films were prepared by casting and drying aqueous mixtures of maltodextrin (DE = 6), glycerin, sorbitan oleate, and DS. Films were characterized in terms of thickness, tensile properties, film disintegration time, and drug dissolution time. The bitterness intensity of DS and the masking effect of TMAs were evaluated by an electronic tongue. RESULTS: The 'mint' and 'licorice' flavors and sucralose mixture resulted appropriate to mask DS bitterness as confirmed by a panel of volunteers. The addition of these TMAs did not significantly affect the film disintegration time (15-20 seconds) and DS dissolution rate (about 5 minutes). CONCLUSION: The electronic tongue was allowed to discriminate the effect of the TMA also in the presence of other hydrosoluble constituents of the film. Therefore, because of its simplicity and rapidity, this technique could assist or even replace the sensory evaluation in the development of fast-dissolving films. SN - 1520-5762 UR - https://www.unboundmedicine.com/medline/citation/20704459/Diclofenac_fast_dissolving_film:_suppression_of_bitterness_by_a_taste_sensing_system_ L2 - http://www.tandfonline.com/doi/full/10.3109/03639045.2010.505928 DB - PRIME DP - Unbound Medicine ER -