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Gastrointestinal microbiota in irritable bowel syndrome: present state and perspectives.

Abstract

Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder that has been associated with aberrant microbiota. This review focuses on the recent molecular insights generated by analysing the intestinal microbiota in subjects suffering from IBS. Special emphasis is given to studies that compare and contrast the microbiota of healthy subjects with that of IBS patients classified into different subgroups based on their predominant bowel pattern as defined by the Rome criteria. The current data available from a limited number of patients do not reveal pronounced and reproducible IBS-related deviations of entire phylogenetic or functional microbial groups, but rather support the concept that IBS patients have alterations in the proportions of commensals with interrelated changes in the metabolic output and overall microbial ecology. The lack of apparent similarities in the taxonomy of microbiota in IBS patients may partially arise from the fact that the applied molecular methods, the nature and location of IBS subjects, and the statistical power of the studies have varied considerably. Most recent advances, especially the finding that several uncharacterized phylotypes show non-random segregation between healthy and IBS subjects, indicate the possibility of discovering bacteria specific for IBS. Moreover, tools are being developed for the functional analysis of the relationship between the intestinal microbiota and IBS. These approaches may be instrumental in the evaluation of the ecological dysbiosis hypothesis in the gut ecosystem. Finally, we discuss the future outlook for research avenues and candidate microbial biomarkers that may eventually be used in IBS diagnosis.

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  • Authors+Show Affiliations

    ,

    Department of Veterinary Biosciences, Veterinary Microbiology and Epidemiology, University of Helsinki, PO Box 66, FI-00014 Helsinki, Finland. anne.salonen@helsinki.fi

    ,

    Source

    Microbiology (Reading, England) 156:Pt 11 2010 Nov pg 3205-15

    MeSH

    Bacteria
    Biomarkers
    DNA, Bacterial
    Feces
    Gastrointestinal Tract
    Humans
    Irritable Bowel Syndrome
    Metagenome
    Phylogeny

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    20705664

    Citation

    Salonen, Anne, et al. "Gastrointestinal Microbiota in Irritable Bowel Syndrome: Present State and Perspectives." Microbiology (Reading, England), vol. 156, no. Pt 11, 2010, pp. 3205-15.
    Salonen A, de Vos WM, Palva A. Gastrointestinal microbiota in irritable bowel syndrome: present state and perspectives. Microbiology (Reading, Engl). 2010;156(Pt 11):3205-15.
    Salonen, A., de Vos, W. M., & Palva, A. (2010). Gastrointestinal microbiota in irritable bowel syndrome: present state and perspectives. Microbiology (Reading, England), 156(Pt 11), pp. 3205-15. doi:10.1099/mic.0.043257-0.
    Salonen A, de Vos WM, Palva A. Gastrointestinal Microbiota in Irritable Bowel Syndrome: Present State and Perspectives. Microbiology (Reading, Engl). 2010;156(Pt 11):3205-15. PubMed PMID: 20705664.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Gastrointestinal microbiota in irritable bowel syndrome: present state and perspectives. AU - Salonen,Anne, AU - de Vos,Willem M, AU - Palva,Airi, Y1 - 2010/08/12/ PY - 2010/8/14/entrez PY - 2010/8/14/pubmed PY - 2011/2/5/medline SP - 3205 EP - 15 JF - Microbiology (Reading, England) JO - Microbiology (Reading, Engl.) VL - 156 IS - Pt 11 N2 - Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder that has been associated with aberrant microbiota. This review focuses on the recent molecular insights generated by analysing the intestinal microbiota in subjects suffering from IBS. Special emphasis is given to studies that compare and contrast the microbiota of healthy subjects with that of IBS patients classified into different subgroups based on their predominant bowel pattern as defined by the Rome criteria. The current data available from a limited number of patients do not reveal pronounced and reproducible IBS-related deviations of entire phylogenetic or functional microbial groups, but rather support the concept that IBS patients have alterations in the proportions of commensals with interrelated changes in the metabolic output and overall microbial ecology. The lack of apparent similarities in the taxonomy of microbiota in IBS patients may partially arise from the fact that the applied molecular methods, the nature and location of IBS subjects, and the statistical power of the studies have varied considerably. Most recent advances, especially the finding that several uncharacterized phylotypes show non-random segregation between healthy and IBS subjects, indicate the possibility of discovering bacteria specific for IBS. Moreover, tools are being developed for the functional analysis of the relationship between the intestinal microbiota and IBS. These approaches may be instrumental in the evaluation of the ecological dysbiosis hypothesis in the gut ecosystem. Finally, we discuss the future outlook for research avenues and candidate microbial biomarkers that may eventually be used in IBS diagnosis. SN - 1465-2080 UR - https://www.unboundmedicine.com/medline/citation/20705664/Gastrointestinal_microbiota_in_irritable_bowel_syndrome:_present_state_and_perspectives_ L2 - http://mic.microbiologyresearch.org/pubmed/content/journal/micro/10.1099/mic.0.043257-0 DB - PRIME DP - Unbound Medicine ER -