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Omega-3 fatty acids and lipoprotein associated phospholipase A(2) in healthy older adult males and females.
Eur J Nutr. 2011 Apr; 50(3):185-93.EJ

Abstract

PURPOSE

Lipoprotein associated phospholipase A(2) (Lp-PLA(2)) is a novel inflammatory factor that has been independently associated with stroke and cardiovascular disease (CVD). Omega-3 fats have been implicated in reducing inflammation associated with CVD. The aim of this study was to determine if an 8-week isocaloric diet supplemented with eicosapentaenoic acid (EPA) and docosahexaenoic (DHA) in the form of fish oil or α-linolenic acid (ALA) in the form of flaxseed oil would alter Lp-PLA(2) among healthy adults ages 50 years and older.

METHODS

Fifty-nine healthy adults (~75% female, average age 61 years) were randomized to one of three groups with equal amounts of total fat intake. All capsules contained ~1 g of fat. The control group (n = 19) consumed olive oil capsules (~11 g/day); the ALA group (n = 20) consumed flaxseed oil capsules (~11 g/day) and the EPA/DHA group (n = 20) consumed fish oil capsules (~2 g/day + 9 g/day of olive oil). Fasting blood samples were obtained before and after the 8-week intervention for determination of Lp-PLA(2) mass and activity as well as lipid values.

RESULTS

We did not find any significant changes in Lp-PLA(2) mass or activity after the intervention in any of the groups; however, change in oxidized LDL was associated with change in Lp-PLA(2) mass (r = 0.37, p < 0.01).

CONCLUSION

Supplementing the diet with omega-3 fatty acids for 8-weeks did not influence Lp-PLA(2) activity or mass among older adults; altering oxidized LDL may be necessary to see changes in Lp-PLA(2) levels.

Authors+Show Affiliations

Human Performance Clinical/Research Laboratory, Department of Health and Exercise Science, Colorado State University, Fort Collins, CO 80523, USA. tnelson@cahs.colostate.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

20706728

Citation

Nelson, T L., et al. "Omega-3 Fatty Acids and Lipoprotein Associated Phospholipase A(2) in Healthy Older Adult Males and Females." European Journal of Nutrition, vol. 50, no. 3, 2011, pp. 185-93.
Nelson TL, Hokanson JE, Hickey MS. Omega-3 fatty acids and lipoprotein associated phospholipase A(2) in healthy older adult males and females. Eur J Nutr. 2011;50(3):185-93.
Nelson, T. L., Hokanson, J. E., & Hickey, M. S. (2011). Omega-3 fatty acids and lipoprotein associated phospholipase A(2) in healthy older adult males and females. European Journal of Nutrition, 50(3), 185-93. https://doi.org/10.1007/s00394-010-0126-7
Nelson TL, Hokanson JE, Hickey MS. Omega-3 Fatty Acids and Lipoprotein Associated Phospholipase A(2) in Healthy Older Adult Males and Females. Eur J Nutr. 2011;50(3):185-93. PubMed PMID: 20706728.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Omega-3 fatty acids and lipoprotein associated phospholipase A(2) in healthy older adult males and females. AU - Nelson,T L, AU - Hokanson,J E, AU - Hickey,M S, Y1 - 2010/08/13/ PY - 2010/02/26/received PY - 2010/07/29/accepted PY - 2010/8/14/entrez PY - 2010/8/14/pubmed PY - 2011/8/13/medline SP - 185 EP - 93 JF - European journal of nutrition JO - Eur J Nutr VL - 50 IS - 3 N2 - PURPOSE: Lipoprotein associated phospholipase A(2) (Lp-PLA(2)) is a novel inflammatory factor that has been independently associated with stroke and cardiovascular disease (CVD). Omega-3 fats have been implicated in reducing inflammation associated with CVD. The aim of this study was to determine if an 8-week isocaloric diet supplemented with eicosapentaenoic acid (EPA) and docosahexaenoic (DHA) in the form of fish oil or α-linolenic acid (ALA) in the form of flaxseed oil would alter Lp-PLA(2) among healthy adults ages 50 years and older. METHODS: Fifty-nine healthy adults (~75% female, average age 61 years) were randomized to one of three groups with equal amounts of total fat intake. All capsules contained ~1 g of fat. The control group (n = 19) consumed olive oil capsules (~11 g/day); the ALA group (n = 20) consumed flaxseed oil capsules (~11 g/day) and the EPA/DHA group (n = 20) consumed fish oil capsules (~2 g/day + 9 g/day of olive oil). Fasting blood samples were obtained before and after the 8-week intervention for determination of Lp-PLA(2) mass and activity as well as lipid values. RESULTS: We did not find any significant changes in Lp-PLA(2) mass or activity after the intervention in any of the groups; however, change in oxidized LDL was associated with change in Lp-PLA(2) mass (r = 0.37, p < 0.01). CONCLUSION: Supplementing the diet with omega-3 fatty acids for 8-weeks did not influence Lp-PLA(2) activity or mass among older adults; altering oxidized LDL may be necessary to see changes in Lp-PLA(2) levels. SN - 1436-6215 UR - https://www.unboundmedicine.com/medline/citation/20706728/Omega_3_fatty_acids_and_lipoprotein_associated_phospholipase_A_2__in_healthy_older_adult_males_and_females_ DB - PRIME DP - Unbound Medicine ER -