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The role of low-grade inflammation in the polycystic ovary syndrome.
Mol Cell Endocrinol. 2011 Mar 15; 335(1):30-41.MC

Abstract

PCOS is not only the most frequent cause of oligomenorrhea in young women, but also a metabolic disorder characterized by insulin resistance, glucose intolerance, dyslipidemia, and obesity, especially the visceral phenotype. PCOS represents a broad spectrum of endocrine and metabolic alterations which change with age and with increasing adiposity. In fact, during adolescence and youth the predominant clinical manifestations of PCOS are menstrual abnormalities, hirsutism and acne, whereas in peri-menopausal and post-menopausal periods metabolic disorders and an increased risk for cardiovascular diseases prevail. The pathogenetic links between PCOS and metabolic or cardiovascular complications are still debated. However, recent evidence has been focused on a condition of low-grade chronic inflammation as a potential cause of the long-term consequence of the syndrome. In this review we describe the state of low-grade inflammation observed in PCOS. In addition, we hypothesize the potential mechanisms responsible for the generation of this inflammatory state and the role played by low-grade inflammation in linking hyperandrogenism and insulin resistance with the metabolic and cardiovascular long-term complications of the syndrome.

Authors+Show Affiliations

Division of Endocrinology, Department of Clinical Medicine, S. Orsola-Malpighi Hospital, University Alma Mater Studiorum of Bologna, Via Massarenti 9, 40138 Bologna, Italy.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

20708064

Citation

Repaci, Andrea, et al. "The Role of Low-grade Inflammation in the Polycystic Ovary Syndrome." Molecular and Cellular Endocrinology, vol. 335, no. 1, 2011, pp. 30-41.
Repaci A, Gambineri A, Pasquali R. The role of low-grade inflammation in the polycystic ovary syndrome. Mol Cell Endocrinol. 2011;335(1):30-41.
Repaci, A., Gambineri, A., & Pasquali, R. (2011). The role of low-grade inflammation in the polycystic ovary syndrome. Molecular and Cellular Endocrinology, 335(1), 30-41. https://doi.org/10.1016/j.mce.2010.08.002
Repaci A, Gambineri A, Pasquali R. The Role of Low-grade Inflammation in the Polycystic Ovary Syndrome. Mol Cell Endocrinol. 2011 Mar 15;335(1):30-41. PubMed PMID: 20708064.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of low-grade inflammation in the polycystic ovary syndrome. AU - Repaci,Andrea, AU - Gambineri,Alessandra, AU - Pasquali,Renato, Y1 - 2010/08/11/ PY - 2009/12/03/received PY - 2010/07/27/revised PY - 2010/08/05/accepted PY - 2010/8/17/entrez PY - 2010/8/17/pubmed PY - 2011/6/15/medline SP - 30 EP - 41 JF - Molecular and cellular endocrinology JO - Mol Cell Endocrinol VL - 335 IS - 1 N2 - PCOS is not only the most frequent cause of oligomenorrhea in young women, but also a metabolic disorder characterized by insulin resistance, glucose intolerance, dyslipidemia, and obesity, especially the visceral phenotype. PCOS represents a broad spectrum of endocrine and metabolic alterations which change with age and with increasing adiposity. In fact, during adolescence and youth the predominant clinical manifestations of PCOS are menstrual abnormalities, hirsutism and acne, whereas in peri-menopausal and post-menopausal periods metabolic disorders and an increased risk for cardiovascular diseases prevail. The pathogenetic links between PCOS and metabolic or cardiovascular complications are still debated. However, recent evidence has been focused on a condition of low-grade chronic inflammation as a potential cause of the long-term consequence of the syndrome. In this review we describe the state of low-grade inflammation observed in PCOS. In addition, we hypothesize the potential mechanisms responsible for the generation of this inflammatory state and the role played by low-grade inflammation in linking hyperandrogenism and insulin resistance with the metabolic and cardiovascular long-term complications of the syndrome. SN - 1872-8057 UR - https://www.unboundmedicine.com/medline/citation/20708064/The_role_of_low_grade_inflammation_in_the_polycystic_ovary_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0303-7207(10)00416-8 DB - PRIME DP - Unbound Medicine ER -