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Isolation and genetic analysis of a novel triple-reassortant H1N1 influenza virus from a pig in China.
Vet Microbiol 2011; 147(3-4):403-9VM

Abstract

Influenza A viruses of subtype H1N1 have been reported widely in pigs in China, associated with clinical disease. These mainly include classical swine H1N1, avian-like H1N1, and human-like H1N1 viruses. In this study, we reported a novel triple-reassortant H1N1 virus (A/swine/Guangdong/1/2010) containing genes from the classical swine (NP, NS), human (PB1) and avian (HA, NA, M, PB2, PA) lineages, which was for the first time reported in China. Also, phylogenetic analysis further confirmed that five genes segments (NS, NP, PB2, PB1, PA) of the isolate were closely related to the novel reassortant H1N2 viruses isolated in China in 2006, while the other three (HA, NA, M) were closely related to avian-like H1N1 viruses in China. The isolation of triple-reassortant H1N1 influenza virus provides further evidence that pigs serve as emergence hosts or "mixing vessels", and swine influenza virus (SIV) surveillance in China should be given a high priority.

Authors+Show Affiliations

Veterinary Public Health Public Laboratory of Guangdong, Veterinary Medicine Institute, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20708352

Citation

Xu, Min, et al. "Isolation and Genetic Analysis of a Novel Triple-reassortant H1N1 Influenza Virus From a Pig in China." Veterinary Microbiology, vol. 147, no. 3-4, 2011, pp. 403-9.
Xu M, Huang Y, Chen J, et al. Isolation and genetic analysis of a novel triple-reassortant H1N1 influenza virus from a pig in China. Vet Microbiol. 2011;147(3-4):403-9.
Xu, M., Huang, Y., Chen, J., Huang, Z., Zhang, J., Zhu, Y., ... Xiang, H. (2011). Isolation and genetic analysis of a novel triple-reassortant H1N1 influenza virus from a pig in China. Veterinary Microbiology, 147(3-4), pp. 403-9. doi:10.1016/j.vetmic.2010.07.012.
Xu M, et al. Isolation and Genetic Analysis of a Novel Triple-reassortant H1N1 Influenza Virus From a Pig in China. Vet Microbiol. 2011 Jan 27;147(3-4):403-9. PubMed PMID: 20708352.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Isolation and genetic analysis of a novel triple-reassortant H1N1 influenza virus from a pig in China. AU - Xu,Min, AU - Huang,Yuan, AU - Chen,Jing, AU - Huang,Zhong, AU - Zhang,Jianfei, AU - Zhu,Yanqiu, AU - Xie,Shouyu, AU - Chen,Qinling, AU - Wei,Wenkang, AU - Yang,Desheng, AU - Huang,Xiaojian, AU - Xuan,Hua, AU - Xiang,Hua, Y1 - 2010/07/22/ PY - 2010/05/19/received PY - 2010/07/07/revised PY - 2010/07/15/accepted PY - 2010/8/17/entrez PY - 2010/8/17/pubmed PY - 2011/6/24/medline SP - 403 EP - 9 JF - Veterinary microbiology JO - Vet. Microbiol. VL - 147 IS - 3-4 N2 - Influenza A viruses of subtype H1N1 have been reported widely in pigs in China, associated with clinical disease. These mainly include classical swine H1N1, avian-like H1N1, and human-like H1N1 viruses. In this study, we reported a novel triple-reassortant H1N1 virus (A/swine/Guangdong/1/2010) containing genes from the classical swine (NP, NS), human (PB1) and avian (HA, NA, M, PB2, PA) lineages, which was for the first time reported in China. Also, phylogenetic analysis further confirmed that five genes segments (NS, NP, PB2, PB1, PA) of the isolate were closely related to the novel reassortant H1N2 viruses isolated in China in 2006, while the other three (HA, NA, M) were closely related to avian-like H1N1 viruses in China. The isolation of triple-reassortant H1N1 influenza virus provides further evidence that pigs serve as emergence hosts or "mixing vessels", and swine influenza virus (SIV) surveillance in China should be given a high priority. SN - 1873-2542 UR - https://www.unboundmedicine.com/medline/citation/20708352/Isolation_and_genetic_analysis_of_a_novel_triple_reassortant_H1N1_influenza_virus_from_a_pig_in_China_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-1135(10)00347-0 DB - PRIME DP - Unbound Medicine ER -