Tags

Type your tag names separated by a space and hit enter

[Oral vitamin B12: Efficacy and safety data in 31 patients with pernicious anemia and food-cobalamin malabsorption].
Presse Med. 2010 Dec; 39(12):e273-9.PM

Abstract

OBJECTIVE

The aim of this study is to validate the efficacy and safety of oral cobalamin therapy in the treatment of cobalamin deficiency related to various causes.

PATIENT AND METHOD

It's a retrospective study, including 31 patients with documented cobalamin deficiency related to food-cobalamin malabsorption (n=20) and pernicious anemia (n=11). These patients were treated at least for 3 months with oral cyanocobalamin, between 125 to 1000microg per day. Serum cobalamin levels and hematological parameters were compared before and after the therapy and in relation with the nature of cobalamin deficiency. Safety data were also recorded.

RESULTS

After 3 months of therapy, the serum cobalamin levels have significantly increased in all the patients, with a mean of +161.6±79.3pg/mL in the food-cobalamin malabsorption group (P<0,00005) and +136.7±67.4pg/mL in the pernicious anemia group (P<0,0001). Hematological parameters have been normalized in 90 % of the patients, independently of the cause of the cobalamin deficiency. Only 1 patient presented an urticarial reaction.

CONCLUSION

This study confirms the efficacy and safety of oral cobalamin therapy in food-cobalamin malabsorption and also in case of pernicious anemia.

Links

Publisher Full Text
linkinghub.elsevier.com
em-consulte.com

Authors+Show Affiliations

Troilo A
Hôpitaux universitaires de Strasbourg, service médecine interne, diabète et maladies métaboliques, clinique médicale B, 67091 Strasbourg cedex, France.
Mecili M
No affiliation info available
Ciobanu E
No affiliation info available
Boddi V
No affiliation info available
D'Elios MM
No affiliation info available
Andrès E
No affiliation info available

MeSH

Administration, OralAdultAgedAged, 80 and overAnemia, PerniciousDose-Response Relationship, DrugDrug EruptionsFemaleFollow-Up StudiesHumansMalabsorption SyndromesMaleRetrospective StudiesTreatment OutcomeVitamin B 12Vitamin B 12 Deficiency

Pub Type(s)

English Abstract
Journal Article

Language

fre

PubMed ID

20708373

Citation

Troilo, Arianna, et al. "[Oral Vitamin B12: Efficacy and Safety Data in 31 Patients With Pernicious Anemia and Food-cobalamin Malabsorption]." Presse Medicale (Paris, France : 1983), vol. 39, no. 12, 2010, pp. e273-9.
Troilo A, Mecili M, Ciobanu E, et al. [Oral vitamin B12: Efficacy and safety data in 31 patients with pernicious anemia and food-cobalamin malabsorption]. Presse Med. 2010;39(12):e273-9.
Troilo, A., Mecili, M., Ciobanu, E., Boddi, V., D'Elios, M. M., & Andrès, E. (2010). [Oral vitamin B12: Efficacy and safety data in 31 patients with pernicious anemia and food-cobalamin malabsorption]. Presse Medicale (Paris, France : 1983), 39(12), e273-9. https://doi.org/10.1016/j.lpm.2010.03.027
Troilo A, et al. [Oral Vitamin B12: Efficacy and Safety Data in 31 Patients With Pernicious Anemia and Food-cobalamin Malabsorption]. Presse Med. 2010;39(12):e273-9. PubMed PMID: 20708373.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Oral vitamin B12: Efficacy and safety data in 31 patients with pernicious anemia and food-cobalamin malabsorption]. AU - Troilo,Arianna, AU - Mecili,Mustapha, AU - Ciobanu,Ecaterina, AU - Boddi,Vieri, AU - D'Elios,Mario M, AU - Andrès,Emmanuel, Y1 - 2010/08/12/ PY - 2009/12/21/received PY - 2010/02/20/revised PY - 2010/03/30/accepted PY - 2010/8/17/entrez PY - 2010/8/17/pubmed PY - 2011/1/5/medline SP - e273 EP - 9 JF - Presse medicale (Paris, France : 1983) JO - Presse Med VL - 39 IS - 12 N2 - OBJECTIVE: The aim of this study is to validate the efficacy and safety of oral cobalamin therapy in the treatment of cobalamin deficiency related to various causes. PATIENT AND METHOD: It's a retrospective study, including 31 patients with documented cobalamin deficiency related to food-cobalamin malabsorption (n=20) and pernicious anemia (n=11). These patients were treated at least for 3 months with oral cyanocobalamin, between 125 to 1000microg per day. Serum cobalamin levels and hematological parameters were compared before and after the therapy and in relation with the nature of cobalamin deficiency. Safety data were also recorded. RESULTS: After 3 months of therapy, the serum cobalamin levels have significantly increased in all the patients, with a mean of +161.6±79.3pg/mL in the food-cobalamin malabsorption group (P<0,00005) and +136.7±67.4pg/mL in the pernicious anemia group (P<0,0001). Hematological parameters have been normalized in 90 % of the patients, independently of the cause of the cobalamin deficiency. Only 1 patient presented an urticarial reaction. CONCLUSION: This study confirms the efficacy and safety of oral cobalamin therapy in food-cobalamin malabsorption and also in case of pernicious anemia. SN - 2213-0276 UR - https://www.unboundmedicine.com/medline/citation/20708373/[Oral_vitamin_B12:_Efficacy_and_safety_data_in_31_patients_with_pernicious_anemia_and_food_cobalamin_malabsorption]_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0755-4982(10)00424-0 DB - PRIME DP - Unbound Medicine ER -