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Exposure to isoflavone-containing soy products and endothelial function: a Bayesian meta-analysis of randomized controlled trials.
Nutr Metab Cardiovasc Dis 2012; 22(3):182-91NM

Abstract

BACKGROUND AND AIMS

To determine whether and to what degree exposure to isoflavone-containing soy products affects EF. Endothelial dysfunction has been identified as an independent coronary heart disease risk factor and a strong predictor of long-term cardiovascular morbidity and mortality. Data on the effects of exposure to isoflavone-containing soy products on EF are conflicting.

METHODS AND RESULTS

A comprehensive literature search was conducted using the PUBMED database (National Library of Medicine, Bethesda, MD) inclusively through August 21, 2009 on RCTs using the keywords: soy, isoflavone, phytoestrogen, EF, flow mediated vasodilation, and FMD. A Bayesian meta-analysis was conducted to provide a comprehensive account of the effect of isoflavone-containing soy products on EF, as measured by FMD. A total of 17 RCTs were selected as having sufficient data for study inclusion. The overall mean absolute change in FMD (95% Bayesian CI) for isoflavone-containing soy product interventions was 1.15% (-0.52, 2.75). When the effects of separate interventions were considered, the treatment effect for isolated isoflavones was 1.98% (0.07, 3.97) compared to 0.72% (-1.39, 2.90) for isoflavone-containing soy protein. The models were not improved when considering study-specific effects such as cuff measurement location, prescribed dietary modification, and impaired baseline FMD.

CONCLUSIONS

Cumulative evidence from the RCTs included in this meta-analysis indicates that exposure to soy isoflavones can modestly, but significantly, improve EF as measured by FMD. Therefore, exposure to isoflavone supplements may beneficially influence vascular health.

Authors+Show Affiliations

Department of Biostatistical Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Review

Language

eng

PubMed ID

20709515

Citation

Beavers, D P., et al. "Exposure to Isoflavone-containing Soy Products and Endothelial Function: a Bayesian Meta-analysis of Randomized Controlled Trials." Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 22, no. 3, 2012, pp. 182-91.
Beavers DP, Beavers KM, Miller M, et al. Exposure to isoflavone-containing soy products and endothelial function: a Bayesian meta-analysis of randomized controlled trials. Nutr Metab Cardiovasc Dis. 2012;22(3):182-91.
Beavers, D. P., Beavers, K. M., Miller, M., Stamey, J., & Messina, M. J. (2012). Exposure to isoflavone-containing soy products and endothelial function: a Bayesian meta-analysis of randomized controlled trials. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 22(3), pp. 182-91. doi:10.1016/j.numecd.2010.05.007.
Beavers DP, et al. Exposure to Isoflavone-containing Soy Products and Endothelial Function: a Bayesian Meta-analysis of Randomized Controlled Trials. Nutr Metab Cardiovasc Dis. 2012;22(3):182-91. PubMed PMID: 20709515.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Exposure to isoflavone-containing soy products and endothelial function: a Bayesian meta-analysis of randomized controlled trials. AU - Beavers,D P, AU - Beavers,K M, AU - Miller,M, AU - Stamey,J, AU - Messina,M J, Y1 - 2010/08/14/ PY - 2010/01/20/received PY - 2010/05/20/revised PY - 2010/05/24/accepted PY - 2010/8/17/entrez PY - 2010/8/17/pubmed PY - 2012/7/10/medline SP - 182 EP - 91 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 22 IS - 3 N2 - BACKGROUND AND AIMS: To determine whether and to what degree exposure to isoflavone-containing soy products affects EF. Endothelial dysfunction has been identified as an independent coronary heart disease risk factor and a strong predictor of long-term cardiovascular morbidity and mortality. Data on the effects of exposure to isoflavone-containing soy products on EF are conflicting. METHODS AND RESULTS: A comprehensive literature search was conducted using the PUBMED database (National Library of Medicine, Bethesda, MD) inclusively through August 21, 2009 on RCTs using the keywords: soy, isoflavone, phytoestrogen, EF, flow mediated vasodilation, and FMD. A Bayesian meta-analysis was conducted to provide a comprehensive account of the effect of isoflavone-containing soy products on EF, as measured by FMD. A total of 17 RCTs were selected as having sufficient data for study inclusion. The overall mean absolute change in FMD (95% Bayesian CI) for isoflavone-containing soy product interventions was 1.15% (-0.52, 2.75). When the effects of separate interventions were considered, the treatment effect for isolated isoflavones was 1.98% (0.07, 3.97) compared to 0.72% (-1.39, 2.90) for isoflavone-containing soy protein. The models were not improved when considering study-specific effects such as cuff measurement location, prescribed dietary modification, and impaired baseline FMD. CONCLUSIONS: Cumulative evidence from the RCTs included in this meta-analysis indicates that exposure to soy isoflavones can modestly, but significantly, improve EF as measured by FMD. Therefore, exposure to isoflavone supplements may beneficially influence vascular health. SN - 1590-3729 UR - https://www.unboundmedicine.com/medline/citation/20709515/Exposure_to_isoflavone_containing_soy_products_and_endothelial_function:_a_Bayesian_meta_analysis_of_randomized_controlled_trials_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-4753(10)00129-8 DB - PRIME DP - Unbound Medicine ER -