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Type 2 diabetes mellitus as a risk factor for the onset of depression: a systematic review and meta-analysis.
Diabetologia 2010; 53(12):2480-6D

Abstract

AIMS/HYPOTHESIS

An earlier meta-analysis showed that diabetes is a risk factor for the development and/or recurrence of depression. Yet whether this risk is different for studies using questionnaires than for those relying on diagnostic criteria for depression has not been examined. This study examined the association of diabetes and the onset of depression by reviewing the literature and conducting a meta-analysis of longitudinal studies on this topic.

METHODS

EMBASE, MEDLINE and PsycInfo were searched for articles published up to September 2009. All studies that examined the relationship between type 2 diabetes and the onset of depression were included. Pooled relative risks were calculated using fixed and random effects models.

RESULTS

Eleven studies met our inclusion criteria for this meta-analysis. Based on the pooled data, including 48,808 cases of type 2 diabetes without depression at baseline, the pooled relative risk was 1.24 (95% CI 1.09-1.40) for the random effects model. This risk was significantly higher for studies relying on diagnostic criteria of depression than for studies using questionnaires. However, this difference was no longer significant when controlled for year of publication.

CONCLUSIONS/INTERPRETATION

Compared with non-diabetic controls, people with type 2 diabetes have a 24% increased risk of developing depression. The mechanisms underlying this relationship are still unclear and warrant further research.

Authors+Show Affiliations

School of Psychology, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK. a.nouwen@bhm.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review

Language

eng

PubMed ID

20711716

Citation

Nouwen, A, et al. "Type 2 Diabetes Mellitus as a Risk Factor for the Onset of Depression: a Systematic Review and Meta-analysis." Diabetologia, vol. 53, no. 12, 2010, pp. 2480-6.
Nouwen A, Winkley K, Twisk J, et al. Type 2 diabetes mellitus as a risk factor for the onset of depression: a systematic review and meta-analysis. Diabetologia. 2010;53(12):2480-6.
Nouwen, A., Winkley, K., Twisk, J., Lloyd, C. E., Peyrot, M., Ismail, K., & Pouwer, F. (2010). Type 2 diabetes mellitus as a risk factor for the onset of depression: a systematic review and meta-analysis. Diabetologia, 53(12), pp. 2480-6. doi:10.1007/s00125-010-1874-x.
Nouwen A, et al. Type 2 Diabetes Mellitus as a Risk Factor for the Onset of Depression: a Systematic Review and Meta-analysis. Diabetologia. 2010;53(12):2480-6. PubMed PMID: 20711716.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Type 2 diabetes mellitus as a risk factor for the onset of depression: a systematic review and meta-analysis. AU - Nouwen,A, AU - Winkley,K, AU - Twisk,J, AU - Lloyd,C E, AU - Peyrot,M, AU - Ismail,K, AU - Pouwer,F, AU - ,, Y1 - 2010/08/14/ PY - 2010/02/17/received PY - 2010/07/13/accepted PY - 2010/8/17/entrez PY - 2010/8/17/pubmed PY - 2011/2/25/medline SP - 2480 EP - 6 JF - Diabetologia JO - Diabetologia VL - 53 IS - 12 N2 - AIMS/HYPOTHESIS: An earlier meta-analysis showed that diabetes is a risk factor for the development and/or recurrence of depression. Yet whether this risk is different for studies using questionnaires than for those relying on diagnostic criteria for depression has not been examined. This study examined the association of diabetes and the onset of depression by reviewing the literature and conducting a meta-analysis of longitudinal studies on this topic. METHODS: EMBASE, MEDLINE and PsycInfo were searched for articles published up to September 2009. All studies that examined the relationship between type 2 diabetes and the onset of depression were included. Pooled relative risks were calculated using fixed and random effects models. RESULTS: Eleven studies met our inclusion criteria for this meta-analysis. Based on the pooled data, including 48,808 cases of type 2 diabetes without depression at baseline, the pooled relative risk was 1.24 (95% CI 1.09-1.40) for the random effects model. This risk was significantly higher for studies relying on diagnostic criteria of depression than for studies using questionnaires. However, this difference was no longer significant when controlled for year of publication. CONCLUSIONS/INTERPRETATION: Compared with non-diabetic controls, people with type 2 diabetes have a 24% increased risk of developing depression. The mechanisms underlying this relationship are still unclear and warrant further research. SN - 1432-0428 UR - http://www.unboundmedicine.com/medline/citation/20711716/full_citation L2 - https://dx.doi.org/10.1007/s00125-010-1874-x DB - PRIME DP - Unbound Medicine ER -