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Mitochondrial Na+/Ca2+ exchanger, a new target for neuroprotection in rat hippocampal slices.
Biochem Biophys Res Commun. 2010 Sep 10; 400(1):140-4.BB

Abstract

We tested here the hypothesis that the pharmacological modulation of the mitochondrial Na(+)/Ca(2+) exchanger (mNCX) could be a new neuroprotective strategy to rescue stressed vulnerable neurons from death. We used rat hippocampal slices incubated with veratridine to cause neuronal death through a mechanism involving Na(+) and Ca(2+) overload. CGP37157 (CGP), an inhibitor of the mNCX, rescued veratridine vulnerable neurons from death, showing an EC(50) of 5 μM. This neuroprotection was associated to mitigation of veratridine-elicited overproduction of free radicals and to inhibition of the p38 MAPK-linked apoptotic pathway. These results suggest that the mNCX could become a new target to develop compounds with potential therapeutic neuroprotective actions in neurodegenerative diseases.

Authors+Show Affiliations

Instituto Teófilo Hernando, Facultad de Medicina, Universidad Autónoma de Madrid, 28029 Madrid, Spain.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20713022

Citation

Nicolau, Santos M., et al. "Mitochondrial Na+/Ca2+ Exchanger, a New Target for Neuroprotection in Rat Hippocampal Slices." Biochemical and Biophysical Research Communications, vol. 400, no. 1, 2010, pp. 140-4.
Nicolau SM, Egea J, López MG, et al. Mitochondrial Na+/Ca2+ exchanger, a new target for neuroprotection in rat hippocampal slices. Biochem Biophys Res Commun. 2010;400(1):140-4.
Nicolau, S. M., Egea, J., López, M. G., & García, A. G. (2010). Mitochondrial Na+/Ca2+ exchanger, a new target for neuroprotection in rat hippocampal slices. Biochemical and Biophysical Research Communications, 400(1), 140-4. https://doi.org/10.1016/j.bbrc.2010.08.028
Nicolau SM, et al. Mitochondrial Na+/Ca2+ Exchanger, a New Target for Neuroprotection in Rat Hippocampal Slices. Biochem Biophys Res Commun. 2010 Sep 10;400(1):140-4. PubMed PMID: 20713022.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mitochondrial Na+/Ca2+ exchanger, a new target for neuroprotection in rat hippocampal slices. AU - Nicolau,Santos M, AU - Egea,Javier, AU - López,Manuela G, AU - García,Antonio G, Y1 - 2010/08/14/ PY - 2010/07/29/received PY - 2010/08/07/accepted PY - 2010/8/18/entrez PY - 2010/8/18/pubmed PY - 2010/10/12/medline SP - 140 EP - 4 JF - Biochemical and biophysical research communications JO - Biochem Biophys Res Commun VL - 400 IS - 1 N2 - We tested here the hypothesis that the pharmacological modulation of the mitochondrial Na(+)/Ca(2+) exchanger (mNCX) could be a new neuroprotective strategy to rescue stressed vulnerable neurons from death. We used rat hippocampal slices incubated with veratridine to cause neuronal death through a mechanism involving Na(+) and Ca(2+) overload. CGP37157 (CGP), an inhibitor of the mNCX, rescued veratridine vulnerable neurons from death, showing an EC(50) of 5 μM. This neuroprotection was associated to mitigation of veratridine-elicited overproduction of free radicals and to inhibition of the p38 MAPK-linked apoptotic pathway. These results suggest that the mNCX could become a new target to develop compounds with potential therapeutic neuroprotective actions in neurodegenerative diseases. SN - 1090-2104 UR - https://www.unboundmedicine.com/medline/citation/20713022/Mitochondrial_Na+/Ca2+_exchanger_a_new_target_for_neuroprotection_in_rat_hippocampal_slices_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-291X(10)01514-7 DB - PRIME DP - Unbound Medicine ER -