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The increase in theta/beta ratio on resting-state EEG in boys with attention-deficit/hyperactivity disorder is mediated by slow alpha peak frequency.

Abstract

Attention-deficit/hyperactivity disorder (ADHD) was found to be characterized by a deviant pattern of electrocortical activity during resting state, particularly increased theta and decreased beta activity. The first objective of the present study is to confirm whether individuals with slow alpha peak frequency contribute to the finding of increased theta activity in ADHD. The second objective is to explore the relation between resting-state brain oscillations and specific cognitive functions. From 49 boys with ADHD and 49 healthy control boys, resting-state EEG during eyes open and eyes closed was recorded, and a variety of cognitive tasks were administered. Theta and beta power and theta/beta ratio were calculated using both fixed frequency bands and individualized frequency bands. As expected, theta/beta ratio, calculated using fixed frequency bands, was significantly higher in ADHD children than control children. However, this group effect was not significant when theta/beta ratio was assessed using individualized frequency bands. No consistent relation was found between resting-state brain oscillations and cognition. The present results suggest that previous findings of increased theta/beta ratio in ADHD may reflect individuals with slow alpha peak frequencies in addition to individuals with true increased theta activity. Therefore, the often reported theta/beta ratio in ADHD can be considered a non-specific measure combining several distinct neurophysiological subgroups such as frontal theta and slowed alpha peak frequencies. Future research should elucidate the functional role of resting-state brain oscillations by investigating neurophysiological subgroups, which may have a clearer relation to cognitive functions than single frequency bands.

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  • Authors+Show Affiliations

    ,

    Department of Psychiatry, Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands. M.Lansbergen@psy.umcn.nl

    , , ,

    Source

    MeSH

    Adolescent
    Alpha Rhythm
    Analysis of Variance
    Attention Deficit Disorder with Hyperactivity
    Beta Rhythm
    Child
    Electroencephalography
    Electrooculography
    Humans
    Male
    Neuropsychological Tests
    Rest
    Statistics as Topic
    Theta Rhythm

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    20713113

    Citation

    Lansbergen, Marieke M., et al. "The Increase in Theta/beta Ratio On Resting-state EEG in Boys With Attention-deficit/hyperactivity Disorder Is Mediated By Slow Alpha Peak Frequency." Progress in Neuro-psychopharmacology & Biological Psychiatry, vol. 35, no. 1, 2011, pp. 47-52.
    Lansbergen MM, Arns M, van Dongen-Boomsma M, et al. The increase in theta/beta ratio on resting-state EEG in boys with attention-deficit/hyperactivity disorder is mediated by slow alpha peak frequency. Prog Neuropsychopharmacol Biol Psychiatry. 2011;35(1):47-52.
    Lansbergen, M. M., Arns, M., van Dongen-Boomsma, M., Spronk, D., & Buitelaar, J. K. (2011). The increase in theta/beta ratio on resting-state EEG in boys with attention-deficit/hyperactivity disorder is mediated by slow alpha peak frequency. Progress in Neuro-psychopharmacology & Biological Psychiatry, 35(1), pp. 47-52. doi:10.1016/j.pnpbp.2010.08.004.
    Lansbergen MM, et al. The Increase in Theta/beta Ratio On Resting-state EEG in Boys With Attention-deficit/hyperactivity Disorder Is Mediated By Slow Alpha Peak Frequency. Prog Neuropsychopharmacol Biol Psychiatry. 2011 Jan 15;35(1):47-52. PubMed PMID: 20713113.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The increase in theta/beta ratio on resting-state EEG in boys with attention-deficit/hyperactivity disorder is mediated by slow alpha peak frequency. AU - Lansbergen,Marieke M, AU - Arns,Martijn, AU - van Dongen-Boomsma,Martine, AU - Spronk,Desirée, AU - Buitelaar,Jan K, Y1 - 2010/08/13/ PY - 2010/06/01/received PY - 2010/07/21/revised PY - 2010/08/05/accepted PY - 2010/8/18/entrez PY - 2010/8/18/pubmed PY - 2011/5/4/medline SP - 47 EP - 52 JF - Progress in neuro-psychopharmacology & biological psychiatry JO - Prog. Neuropsychopharmacol. Biol. Psychiatry VL - 35 IS - 1 N2 - Attention-deficit/hyperactivity disorder (ADHD) was found to be characterized by a deviant pattern of electrocortical activity during resting state, particularly increased theta and decreased beta activity. The first objective of the present study is to confirm whether individuals with slow alpha peak frequency contribute to the finding of increased theta activity in ADHD. The second objective is to explore the relation between resting-state brain oscillations and specific cognitive functions. From 49 boys with ADHD and 49 healthy control boys, resting-state EEG during eyes open and eyes closed was recorded, and a variety of cognitive tasks were administered. Theta and beta power and theta/beta ratio were calculated using both fixed frequency bands and individualized frequency bands. As expected, theta/beta ratio, calculated using fixed frequency bands, was significantly higher in ADHD children than control children. However, this group effect was not significant when theta/beta ratio was assessed using individualized frequency bands. No consistent relation was found between resting-state brain oscillations and cognition. The present results suggest that previous findings of increased theta/beta ratio in ADHD may reflect individuals with slow alpha peak frequencies in addition to individuals with true increased theta activity. Therefore, the often reported theta/beta ratio in ADHD can be considered a non-specific measure combining several distinct neurophysiological subgroups such as frontal theta and slowed alpha peak frequencies. Future research should elucidate the functional role of resting-state brain oscillations by investigating neurophysiological subgroups, which may have a clearer relation to cognitive functions than single frequency bands. SN - 1878-4216 UR - https://www.unboundmedicine.com/medline/citation/20713113/The_increase_in_theta/beta_ratio_on_resting_state_EEG_in_boys_with_attention_deficit/hyperactivity_disorder_is_mediated_by_slow_alpha_peak_frequency_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-5846(10)00307-6 DB - PRIME DP - Unbound Medicine ER -