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Dietary acrylamide intake and risk of esophageal cancer in a population-based case-control study in Sweden.
Int J Cancer. 2011 Feb 01; 128(3):676-81.IJ

Abstract

Acrylamide is a potential carcinogen, which commonly occurs in some food items. The relation between acrylamide and esophageal cancer deserves attention. In a Swedish nationwide, population-based case-control study, data were collected on diet among other variables in 1995-1997 through personal interviews. Included were 189 cases of esophageal adenocarcinoma (participation rate 88%), 262 cases of gastroesophageal junctional adenocarcinoma (84%), 167 cases of esophageal squamous cell carcinoma (73%), and 820 control participants (73%). Dietary intake of acrylamide exposure was assessed from a food-frequency questionnaire and categorized into quartiles based on the consumption among the control participants. Unconditional logistic regression was used to calculate odds ratios (OR) with 95% confidence intervals (CI), with multivariable adjustment for known risk factors. Among participants in the highest quartile of acrylamide exposure compared to the lowest, the adjusted risk of all esophageal tumors combined was increased (OR 1.23; 95% CI 1.02-1.75), particularly among overweight or obese persons (OR 1.88; 95% CI 1.06-3.34). Increased point risk estimates were found for each type of esophageal cancer, but the association with esophageal squamous cell carcinoma seemed stronger and was statistically significant, particularly among nonsmokers in the highest quartile of acrylamide exposure (adjusted OR 2.82; 95% CI 1.16-6.87). Regarding squamous cell carcinoma only, a dose-response association was identified (p for trend 0.01). Dietary intake of acrylamide might be a risk exposure for esophageal cancer, a stronger association among overweight or obese persons was indicated.

Authors+Show Affiliations

Department of Molecular Medicine and Surgery, Upper Gastrointestinal Research, Karolinska Institutet, Stockholm, Sweden. yulan.lin.184@student.ki.seNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20715108

Citation

Lin, Yulan, et al. "Dietary Acrylamide Intake and Risk of Esophageal Cancer in a Population-based Case-control Study in Sweden." International Journal of Cancer, vol. 128, no. 3, 2011, pp. 676-81.
Lin Y, Lagergren J, Lu Y. Dietary acrylamide intake and risk of esophageal cancer in a population-based case-control study in Sweden. Int J Cancer. 2011;128(3):676-81.
Lin, Y., Lagergren, J., & Lu, Y. (2011). Dietary acrylamide intake and risk of esophageal cancer in a population-based case-control study in Sweden. International Journal of Cancer, 128(3), 676-81. https://doi.org/10.1002/ijc.25608
Lin Y, Lagergren J, Lu Y. Dietary Acrylamide Intake and Risk of Esophageal Cancer in a Population-based Case-control Study in Sweden. Int J Cancer. 2011 Feb 1;128(3):676-81. PubMed PMID: 20715108.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary acrylamide intake and risk of esophageal cancer in a population-based case-control study in Sweden. AU - Lin,Yulan, AU - Lagergren,Jesper, AU - Lu,Yunxia, PY - 2010/8/18/entrez PY - 2010/8/18/pubmed PY - 2011/1/15/medline SP - 676 EP - 81 JF - International journal of cancer JO - Int J Cancer VL - 128 IS - 3 N2 - Acrylamide is a potential carcinogen, which commonly occurs in some food items. The relation between acrylamide and esophageal cancer deserves attention. In a Swedish nationwide, population-based case-control study, data were collected on diet among other variables in 1995-1997 through personal interviews. Included were 189 cases of esophageal adenocarcinoma (participation rate 88%), 262 cases of gastroesophageal junctional adenocarcinoma (84%), 167 cases of esophageal squamous cell carcinoma (73%), and 820 control participants (73%). Dietary intake of acrylamide exposure was assessed from a food-frequency questionnaire and categorized into quartiles based on the consumption among the control participants. Unconditional logistic regression was used to calculate odds ratios (OR) with 95% confidence intervals (CI), with multivariable adjustment for known risk factors. Among participants in the highest quartile of acrylamide exposure compared to the lowest, the adjusted risk of all esophageal tumors combined was increased (OR 1.23; 95% CI 1.02-1.75), particularly among overweight or obese persons (OR 1.88; 95% CI 1.06-3.34). Increased point risk estimates were found for each type of esophageal cancer, but the association with esophageal squamous cell carcinoma seemed stronger and was statistically significant, particularly among nonsmokers in the highest quartile of acrylamide exposure (adjusted OR 2.82; 95% CI 1.16-6.87). Regarding squamous cell carcinoma only, a dose-response association was identified (p for trend 0.01). Dietary intake of acrylamide might be a risk exposure for esophageal cancer, a stronger association among overweight or obese persons was indicated. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/20715108/Dietary_acrylamide_intake_and_risk_of_esophageal_cancer_in_a_population_based_case_control_study_in_Sweden_ L2 - https://doi.org/10.1002/ijc.25608 DB - PRIME DP - Unbound Medicine ER -