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[Roles of cyclin-dependent kinase 5 in central nervous system development and neurodegenerative diseases].
Sheng Li Xue Bao. 2010 Aug 25; 62(4):295-308.SL

Abstract

Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase, and plays multiple roles in neuron development and synaptic plasticity. The active form of Cdk5 is found primarily in the central nervous system (CNS) due to its activator proteins p35 or p39 ubiquitously expressed in neuronal cells. Normally, the transcription and activity of Cdk5 are strictly regulated by several ways. In the physiological condition, Cdk5 plays a key role in the CNS development by phosphorylating the specific serine or threonine site of numerous substrate proteins that are closely associated with the neuronal migration, synaptogenesis, synaptic transmission as well as synaptic plasticity. Under pathological conditions, p35 can be truncated into p25, which can strongly and consistently activate Cdk5, change the cellular localization of Cdk5 and lead to neuronal death ultimately. The increasing evidence has showed that Cdk5 is involved in the pathogenesis of many neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, Huntington's disease and amyotrophic lateral sclerosis etc., indicating that Cdk5 may be a potential target in the treatment of the neurodegenerative diseases. In this article, we reviewed the recent progress regarding the roles of Cdk5 in CNS development and neurodegenerative diseases.

Authors+Show Affiliations

Institutes of Brain Science, Institute of Neurobiology and State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

chi

PubMed ID

20717630

Citation

Chen, Jie, and Zhong-Feng Wang. "[Roles of Cyclin-dependent Kinase 5 in Central Nervous System Development and Neurodegenerative Diseases]." Sheng Li Xue Bao : [Acta Physiologica Sinica], vol. 62, no. 4, 2010, pp. 295-308.
Chen J, Wang ZF. [Roles of cyclin-dependent kinase 5 in central nervous system development and neurodegenerative diseases]. Sheng Li Xue Bao. 2010;62(4):295-308.
Chen, J., & Wang, Z. F. (2010). [Roles of cyclin-dependent kinase 5 in central nervous system development and neurodegenerative diseases]. Sheng Li Xue Bao : [Acta Physiologica Sinica], 62(4), 295-308.
Chen J, Wang ZF. [Roles of Cyclin-dependent Kinase 5 in Central Nervous System Development and Neurodegenerative Diseases]. Sheng Li Xue Bao. 2010 Aug 25;62(4):295-308. PubMed PMID: 20717630.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Roles of cyclin-dependent kinase 5 in central nervous system development and neurodegenerative diseases]. AU - Chen,Jie, AU - Wang,Zhong-Feng, PY - 2010/8/19/entrez PY - 2010/8/19/pubmed PY - 2013/1/25/medline SP - 295 EP - 308 JF - Sheng li xue bao : [Acta physiologica Sinica] JO - Sheng Li Xue Bao VL - 62 IS - 4 N2 - Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase, and plays multiple roles in neuron development and synaptic plasticity. The active form of Cdk5 is found primarily in the central nervous system (CNS) due to its activator proteins p35 or p39 ubiquitously expressed in neuronal cells. Normally, the transcription and activity of Cdk5 are strictly regulated by several ways. In the physiological condition, Cdk5 plays a key role in the CNS development by phosphorylating the specific serine or threonine site of numerous substrate proteins that are closely associated with the neuronal migration, synaptogenesis, synaptic transmission as well as synaptic plasticity. Under pathological conditions, p35 can be truncated into p25, which can strongly and consistently activate Cdk5, change the cellular localization of Cdk5 and lead to neuronal death ultimately. The increasing evidence has showed that Cdk5 is involved in the pathogenesis of many neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, Huntington's disease and amyotrophic lateral sclerosis etc., indicating that Cdk5 may be a potential target in the treatment of the neurodegenerative diseases. In this article, we reviewed the recent progress regarding the roles of Cdk5 in CNS development and neurodegenerative diseases. SN - 0371-0874 UR - https://www.unboundmedicine.com/medline/citation/20717630/[Roles_of_cyclin_dependent_kinase_5_in_central_nervous_system_development_and_neurodegenerative_diseases]_ L2 - http://www.actaps.com.cn/qikan/manage/wenzhang/2010-4-02.pdf DB - PRIME DP - Unbound Medicine ER -