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Postinfectious bronchiolitis obliterans in children: clinical and pulmonary function findings.
Pediatr Pulmonol 2010; 45(12):1180-5PP

Abstract

AIM

Postinfectious bronchiolitis obliterans (PIBO) is an infrequent yet potentially severe disorder following acute lower pulmonary infection (ALRI) in children. In infants and young children PIBO have been strongly associated with Adenovirus (Ad). The purpose of this study was to analyze the clinical features and pulmonary function findings in children with PIBO. Cases caused by Ad were compared with cases in which no viral agent was identified.

METHODS

Fifty-eight children with PIBO were prospectively studied. Clinical data and pulmonary function tests (spirometry and plethysmography) were evaluated. Patients were divided in two groups according to the identification of the causal agent. Group 1 (G1): Adenovirus (+) Group 2: No etiologic agent identified.

RESULTS

Fifty-eight patients (male/female ratio 3.4:1); median age 8 years; mean age at initial injury 11 months; median time of hospitalization at acute stage of disease 60 days. Spirometry: FVC 68 ± 13%, FEV1 40.5 ± 11%, FMMF(25-75%) 16.7 ± 7.5%. Pletysmography: TLC 136 ± 22%, FRC 208 ± 50%, RV 343 ± 102%, RV/TLC 59 ± 10, SGaw 0.05 ± 0.02. When clinical, spirometric and plethysmographic data were compared, no statistically significant difference was found between the two groups.

CONCLUSIONS

PIBO is an extremely crippling lung disease with significant obstructive pattern in PFT. Both analyzed groups shared similar characteristics in the acute phase of the disease and in the severity of the sequelar pulmonary disease.

Authors+Show Affiliations

Pulmonology Department, Hospital de Pediatria Dr Juan P Garrahan, Buenos Aires, Argentina. vaguerre@garrahan.gov.arNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

20717912

Citation

Aguerre, V, et al. "Postinfectious Bronchiolitis Obliterans in Children: Clinical and Pulmonary Function Findings." Pediatric Pulmonology, vol. 45, no. 12, 2010, pp. 1180-5.
Aguerre V, Castaños C, Pena HG, et al. Postinfectious bronchiolitis obliterans in children: clinical and pulmonary function findings. Pediatr Pulmonol. 2010;45(12):1180-5.
Aguerre, V., Castaños, C., Pena, H. G., Grenoville, M., & Murtagh, P. (2010). Postinfectious bronchiolitis obliterans in children: clinical and pulmonary function findings. Pediatric Pulmonology, 45(12), pp. 1180-5. doi:10.1002/ppul.21304.
Aguerre V, et al. Postinfectious Bronchiolitis Obliterans in Children: Clinical and Pulmonary Function Findings. Pediatr Pulmonol. 2010;45(12):1180-5. PubMed PMID: 20717912.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Postinfectious bronchiolitis obliterans in children: clinical and pulmonary function findings. AU - Aguerre,V, AU - Castaños,C, AU - Pena,H Gonzalez, AU - Grenoville,M, AU - Murtagh,P, Y1 - 2010/08/17/ PY - 2009/11/20/received PY - 2010/04/18/revised PY - 2010/04/22/accepted PY - 2010/8/19/entrez PY - 2010/8/19/pubmed PY - 2011/3/30/medline SP - 1180 EP - 5 JF - Pediatric pulmonology JO - Pediatr. Pulmonol. VL - 45 IS - 12 N2 - AIM: Postinfectious bronchiolitis obliterans (PIBO) is an infrequent yet potentially severe disorder following acute lower pulmonary infection (ALRI) in children. In infants and young children PIBO have been strongly associated with Adenovirus (Ad). The purpose of this study was to analyze the clinical features and pulmonary function findings in children with PIBO. Cases caused by Ad were compared with cases in which no viral agent was identified. METHODS: Fifty-eight children with PIBO were prospectively studied. Clinical data and pulmonary function tests (spirometry and plethysmography) were evaluated. Patients were divided in two groups according to the identification of the causal agent. Group 1 (G1): Adenovirus (+) Group 2: No etiologic agent identified. RESULTS: Fifty-eight patients (male/female ratio 3.4:1); median age 8 years; mean age at initial injury 11 months; median time of hospitalization at acute stage of disease 60 days. Spirometry: FVC 68 ± 13%, FEV1 40.5 ± 11%, FMMF(25-75%) 16.7 ± 7.5%. Pletysmography: TLC 136 ± 22%, FRC 208 ± 50%, RV 343 ± 102%, RV/TLC 59 ± 10, SGaw 0.05 ± 0.02. When clinical, spirometric and plethysmographic data were compared, no statistically significant difference was found between the two groups. CONCLUSIONS: PIBO is an extremely crippling lung disease with significant obstructive pattern in PFT. Both analyzed groups shared similar characteristics in the acute phase of the disease and in the severity of the sequelar pulmonary disease. SN - 1099-0496 UR - https://www.unboundmedicine.com/medline/citation/20717912/Postinfectious_bronchiolitis_obliterans_in_children:_clinical_and_pulmonary_function_findings_ L2 - https://doi.org/10.1002/ppul.21304 DB - PRIME DP - Unbound Medicine ER -