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[Association between HLA-DQA1 gene polymorphism and the outcomes of hepatitis B virus infection].

Abstract

OBJECTIVE

To investigate the association between HLA-DQA1 gene polymorphism and the outcomes of hepatitis B virus infection in Chinese Han population.

METHODS

A total of 180 consecutive patients with biopsy-proven hepatitis B virus infection (120 patients with chronic hepatitis B and 60 patients with asymptomatic HBV carrier) and 60 subjects who resolved from HBV infection spontaneously were studied. Genotype of human leukocyte antigen(HLA)-DQA1 was detected by polymerase chain reaction sequence specific primer(PCR-SSP).

RESULTS

(1) The frequency of HLA-DQA1 * 0201 allele in chronic hepatitis B group was significant higher than the frequency in resolved from HBV infection spontaneously group (38.3% vs. 5.8%, P < 0.001, A = 10.04, 95% CI: 4.48-22.48). The frequency of HLA-DQA1 * 0102 allele in chronic hepatitis B group was significant lower than the frequency in resolved from HBV infection spontaneously group (9.6% vs. 36.7%, P < 0.001, A = 0.183, 95% CI: 0.10-0.32). (2) The frequency of HLA-DQA1 * 0201 allele in chronic hepatitis B group was significant higher than the frequency in asymptomatic HBV carrier group (38.3% vs. 7.5%, P < 0.01, A = 7.667, 95% CI:3.7-15.87). The frequency of HLA-DQA1 * 0102 allele in chronic hepatitis B group was significant lower than the frequency in asymptomatic HBV carrier group (20% vs. 9.6%, P < 0.01, A = 0.424, 95% CI: 0.23-0.79).

CONCLUSION

HLA-DQA1 gene polymorphism may play an important role in the outcomes of hepatitis B virus infection in-Chinese Han population. The HLA-DQA1 * 0102 allele could keep individuals away from HBV infection, and HLA-DQA1 * 0201 allele could aggravate persistant infection of HBV and hepatic inflammatory.

Authors+Show Affiliations

Hangzhou 6th Hospital, Hangzhou 310014, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

20718347

Citation

Xun, Yun-hao, et al. "[Association Between HLA-DQA1 Gene Polymorphism and the Outcomes of Hepatitis B Virus Infection]." Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi = Zhonghua Shiyan He Linchuang Bingduxue Zazhi = Chinese Journal of Experimental and Clinical Virology, vol. 23, no. 6, 2009, pp. 430-3.
Xun YH, Guo JC, Shi WZ, et al. [Association between HLA-DQA1 gene polymorphism and the outcomes of hepatitis B virus infection]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2009;23(6):430-3.
Xun, Y. H., Guo, J. C., Shi, W. Z., Shi, J. P., & Liu, C. L. (2009). [Association between HLA-DQA1 gene polymorphism and the outcomes of hepatitis B virus infection]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi = Zhonghua Shiyan He Linchuang Bingduxue Zazhi = Chinese Journal of Experimental and Clinical Virology, 23(6), 430-3.
Xun YH, et al. [Association Between HLA-DQA1 Gene Polymorphism and the Outcomes of Hepatitis B Virus Infection]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2009;23(6):430-3. PubMed PMID: 20718347.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Association between HLA-DQA1 gene polymorphism and the outcomes of hepatitis B virus infection]. AU - Xun,Yun-hao, AU - Guo,Jian-chun, AU - Shi,Wei-zhen, AU - Shi,Jun-ping, AU - Liu,Chang-ling, PY - 2010/8/20/entrez PY - 2010/8/20/pubmed PY - 2010/9/18/medline SP - 430 EP - 3 JF - Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology JO - Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi VL - 23 IS - 6 N2 - OBJECTIVE: To investigate the association between HLA-DQA1 gene polymorphism and the outcomes of hepatitis B virus infection in Chinese Han population. METHODS: A total of 180 consecutive patients with biopsy-proven hepatitis B virus infection (120 patients with chronic hepatitis B and 60 patients with asymptomatic HBV carrier) and 60 subjects who resolved from HBV infection spontaneously were studied. Genotype of human leukocyte antigen(HLA)-DQA1 was detected by polymerase chain reaction sequence specific primer(PCR-SSP). RESULTS: (1) The frequency of HLA-DQA1 * 0201 allele in chronic hepatitis B group was significant higher than the frequency in resolved from HBV infection spontaneously group (38.3% vs. 5.8%, P < 0.001, A = 10.04, 95% CI: 4.48-22.48). The frequency of HLA-DQA1 * 0102 allele in chronic hepatitis B group was significant lower than the frequency in resolved from HBV infection spontaneously group (9.6% vs. 36.7%, P < 0.001, A = 0.183, 95% CI: 0.10-0.32). (2) The frequency of HLA-DQA1 * 0201 allele in chronic hepatitis B group was significant higher than the frequency in asymptomatic HBV carrier group (38.3% vs. 7.5%, P < 0.01, A = 7.667, 95% CI:3.7-15.87). The frequency of HLA-DQA1 * 0102 allele in chronic hepatitis B group was significant lower than the frequency in asymptomatic HBV carrier group (20% vs. 9.6%, P < 0.01, A = 0.424, 95% CI: 0.23-0.79). CONCLUSION: HLA-DQA1 gene polymorphism may play an important role in the outcomes of hepatitis B virus infection in-Chinese Han population. The HLA-DQA1 * 0102 allele could keep individuals away from HBV infection, and HLA-DQA1 * 0201 allele could aggravate persistant infection of HBV and hepatic inflammatory. SN - 1003-9279 UR - https://www.unboundmedicine.com/medline/citation/20718347/[Association_between_HLA_DQA1_gene_polymorphism_and_the_outcomes_of_hepatitis_B_virus_infection]_ L2 - http://www.diseaseinfosearch.org/result/3332 DB - PRIME DP - Unbound Medicine ER -