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Preparation of monodisperse chitosan microcapsules with hollow structures using the SPG membrane emulsification technique.
Langmuir. 2010 Sep 21; 26(18):14854-60.L

Abstract

We describe herein successful preparations of monodisperse chitosan microcapsules with hollow structures using the SPG membrane emulsification technique. Two preparation procedures were examined in this study. In the first method, monodisperse calcium alginate microspheres were prepared and then coated with unmodified chitosan. Subsequently, tripolyphosphate treatment was conducted to physically cross-link chitosan and solubilize the alginate core at the same time. In the second method, photo-cross-linkable chitosan was coated onto the monodisperse calcium alginate microspheres, followed by UV irradiation to chemically cross-link the chitosan shell and tripolyphosphate treatment to solubilize the core. For both methods, it was determined that the average diameters of the chitosan microcapsules depended on those of the calcium alginate microparticles and that the microcapsules have hollow structures. In addition, the first physical cross-linking method using tripolyphosphate was found to be preferable to obtain the hollow structure, compared with the second method using chemical cross-linking by UV irradiation. This was because of the difference in the resistance to permeation of the solubilized alginate through the chitosan shell layers.

Authors+Show Affiliations

Department of Chemical System Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan. akamatsu@cc.kogakuin.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20718480

Citation

Akamatsu, Kazuki, et al. "Preparation of Monodisperse Chitosan Microcapsules With Hollow Structures Using the SPG Membrane Emulsification Technique." Langmuir : the ACS Journal of Surfaces and Colloids, vol. 26, no. 18, 2010, pp. 14854-60.
Akamatsu K, Chen W, Suzuki Y, et al. Preparation of monodisperse chitosan microcapsules with hollow structures using the SPG membrane emulsification technique. Langmuir. 2010;26(18):14854-60.
Akamatsu, K., Chen, W., Suzuki, Y., Ito, T., Nakao, A., Sugawara, T., Kikuchi, R., & Nakao, S. (2010). Preparation of monodisperse chitosan microcapsules with hollow structures using the SPG membrane emulsification technique. Langmuir : the ACS Journal of Surfaces and Colloids, 26(18), 14854-60. https://doi.org/10.1021/la101967u
Akamatsu K, et al. Preparation of Monodisperse Chitosan Microcapsules With Hollow Structures Using the SPG Membrane Emulsification Technique. Langmuir. 2010 Sep 21;26(18):14854-60. PubMed PMID: 20718480.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preparation of monodisperse chitosan microcapsules with hollow structures using the SPG membrane emulsification technique. AU - Akamatsu,Kazuki, AU - Chen,Wei, AU - Suzuki,Yukimitsu, AU - Ito,Taichi, AU - Nakao,Aiko, AU - Sugawara,Takashi, AU - Kikuchi,Ryuji, AU - Nakao,Shin-ichi, PY - 2010/8/20/entrez PY - 2010/8/20/pubmed PY - 2011/1/5/medline SP - 14854 EP - 60 JF - Langmuir : the ACS journal of surfaces and colloids JO - Langmuir VL - 26 IS - 18 N2 - We describe herein successful preparations of monodisperse chitosan microcapsules with hollow structures using the SPG membrane emulsification technique. Two preparation procedures were examined in this study. In the first method, monodisperse calcium alginate microspheres were prepared and then coated with unmodified chitosan. Subsequently, tripolyphosphate treatment was conducted to physically cross-link chitosan and solubilize the alginate core at the same time. In the second method, photo-cross-linkable chitosan was coated onto the monodisperse calcium alginate microspheres, followed by UV irradiation to chemically cross-link the chitosan shell and tripolyphosphate treatment to solubilize the core. For both methods, it was determined that the average diameters of the chitosan microcapsules depended on those of the calcium alginate microparticles and that the microcapsules have hollow structures. In addition, the first physical cross-linking method using tripolyphosphate was found to be preferable to obtain the hollow structure, compared with the second method using chemical cross-linking by UV irradiation. This was because of the difference in the resistance to permeation of the solubilized alginate through the chitosan shell layers. SN - 1520-5827 UR - https://www.unboundmedicine.com/medline/citation/20718480/Preparation_of_monodisperse_chitosan_microcapsules_with_hollow_structures_using_the_SPG_membrane_emulsification_technique_ L2 - https://doi.org/10.1021/la101967u DB - PRIME DP - Unbound Medicine ER -