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Cancers attributable to human papillomavirus infection.
Sex Health 2010; 7(3):244-52SH

Abstract

Although the human papillomavirus (HPV) vaccine was introduced primarily as a cervical cancer prevention vaccine, HPV has a causal role in several types of cancer. This article reviews the epidemiological evidence for the role of HPV in human cancer, and describes Australian trends in these cancers. HPV is a necessary cause of cervical cancer. The currently vaccine-preventable subtypes of HPV 16 and 18 are responsible for ~70% of cervical cancer. The introduction of an organised Pap smear program in Australia led to a steep decline in incidence over the past decades. HPV can be detected in ~40% and 70% of vulval and vaginal cancers respectively. Rates of these cancers have been stable over the past 20 years. The prevalence of HPV in penile cancer is ~50% and incidence has not recently changed. For anal cancer, ~85% of cases are HPV positive, and incidence has increased significantly in both men and women over the past 20 years. In the oral cavity, ~35% of oropharyngeal cancers and ~25% of other oral cavity cancers are HPV positive. The incidence of HPV-related oral cavity and oropharyngeal cancers is increasing, whereas incidence at HPV-unrelated sites is decreasing. Overall, 1154 HPV-related cancer cases were potentially preventable by vaccination. If HPV-related cancers at non-cervical sites are prevented by vaccination, then a similar number of cancer cases will be prevented as in the cervix. However, almost one-quarter of the potentially preventable cancer cases are in men, who are not included in the current national immunisation program.

Authors+Show Affiliations

National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, NSW 2021, Australia. agrulich@nchecr.unsw.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

20719211

Citation

Grulich, Andrew E., et al. "Cancers Attributable to Human Papillomavirus Infection." Sexual Health, vol. 7, no. 3, 2010, pp. 244-52.
Grulich AE, Jin F, Conway EL, et al. Cancers attributable to human papillomavirus infection. Sex Health. 2010;7(3):244-52.
Grulich, A. E., Jin, F., Conway, E. L., Stein, A. N., & Hocking, J. (2010). Cancers attributable to human papillomavirus infection. Sexual Health, 7(3), pp. 244-52. doi:10.1071/SH10020.
Grulich AE, et al. Cancers Attributable to Human Papillomavirus Infection. Sex Health. 2010;7(3):244-52. PubMed PMID: 20719211.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cancers attributable to human papillomavirus infection. AU - Grulich,Andrew E, AU - Jin,Fengyi, AU - Conway,E Lynne, AU - Stein,Alicia N, AU - Hocking,Jane, PY - 2010/02/18/received PY - 2010/04/19/accepted PY - 2010/8/20/entrez PY - 2010/8/20/pubmed PY - 2010/12/21/medline SP - 244 EP - 52 JF - Sexual health JO - Sex Health VL - 7 IS - 3 N2 - Although the human papillomavirus (HPV) vaccine was introduced primarily as a cervical cancer prevention vaccine, HPV has a causal role in several types of cancer. This article reviews the epidemiological evidence for the role of HPV in human cancer, and describes Australian trends in these cancers. HPV is a necessary cause of cervical cancer. The currently vaccine-preventable subtypes of HPV 16 and 18 are responsible for ~70% of cervical cancer. The introduction of an organised Pap smear program in Australia led to a steep decline in incidence over the past decades. HPV can be detected in ~40% and 70% of vulval and vaginal cancers respectively. Rates of these cancers have been stable over the past 20 years. The prevalence of HPV in penile cancer is ~50% and incidence has not recently changed. For anal cancer, ~85% of cases are HPV positive, and incidence has increased significantly in both men and women over the past 20 years. In the oral cavity, ~35% of oropharyngeal cancers and ~25% of other oral cavity cancers are HPV positive. The incidence of HPV-related oral cavity and oropharyngeal cancers is increasing, whereas incidence at HPV-unrelated sites is decreasing. Overall, 1154 HPV-related cancer cases were potentially preventable by vaccination. If HPV-related cancers at non-cervical sites are prevented by vaccination, then a similar number of cancer cases will be prevented as in the cervix. However, almost one-quarter of the potentially preventable cancer cases are in men, who are not included in the current national immunisation program. SN - 1448-5028 UR - https://www.unboundmedicine.com/medline/citation/20719211/Cancers_attributable_to_human_papillomavirus_infection_ L2 - https://www.who.int/reproductivehealth/publications/cancers/a92126/en/ DB - PRIME DP - Unbound Medicine ER -