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A case of relapse with drug-susceptible M. leprae after multidrug therapy.
Int J Lepr Other Mycobact Dis. 1991 Jun; 59(2):242-7.IJ

Abstract

A male born in 1930 was diagnosed as smear-positive borderline leprosy in 1971, and was treated with dapsone and/or sulfamethoxypyridazine from 1972 to 1980 with clinical improvement. However, new skin lesions with smears strongly positive appeared in August 1980, and he was diagnosed as having downgraded to lepromatous (LL) leprosy, but the bacilli recovered from the skin biopsy were fully susceptible to both dapsone and rifampin by mouse foot pad technique. Between 1981 and 1983, the patient was treated with 24 months of rifampin 600 mg and dapsone 100 mg daily, supplemented with prothionamide 500 mg daily during the initial 3 months, and his skin lesions gradually improved during treatment with the combined regimen. Afterward, the patient was kept under surveillance without treatment. From 1984 to 1986, his skin smears were negative, and no bacilli could be found from a skin biopsy taken in 1985. Then in 1987, 52 months after stopping treatment, new skin lesions appeared with a high concentration of Mycobacterium leprae (2 x 10(6)/mg tissue). The drug-susceptibility test again demonstrated that the organisms were fully susceptible to both dapsone and rifampin. Apparently the relapse was due to remultiplication of drug-susceptible persisters.

Authors+Show Affiliations

Hôpital Clarac, Centre Hospitalier Regional Universitaire de Fort-de-France, Martinique, French West Indies.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

2071981

Citation

Constant-Desportes, M, et al. "A Case of Relapse With Drug-susceptible M. Leprae After Multidrug Therapy." International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association, vol. 59, no. 2, 1991, pp. 242-7.
Constant-Desportes M, Guelpa-Lauras CC, Carolina JC, et al. A case of relapse with drug-susceptible M. leprae after multidrug therapy. Int J Lepr Other Mycobact Dis. 1991;59(2):242-7.
Constant-Desportes, M., Guelpa-Lauras, C. C., Carolina, J. C., Léoture, A., Grosset, J. H., & Sansarricq, H. (1991). A case of relapse with drug-susceptible M. leprae after multidrug therapy. International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association, 59(2), 242-7.
Constant-Desportes M, et al. A Case of Relapse With Drug-susceptible M. Leprae After Multidrug Therapy. Int J Lepr Other Mycobact Dis. 1991;59(2):242-7. PubMed PMID: 2071981.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A case of relapse with drug-susceptible M. leprae after multidrug therapy. AU - Constant-Desportes,M, AU - Guelpa-Lauras,C C, AU - Carolina,J C, AU - Léoture,A, AU - Grosset,J H, AU - Sansarricq,H, PY - 1991/6/1/pubmed PY - 1991/6/1/medline PY - 1991/6/1/entrez SP - 242 EP - 7 JF - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association JO - Int J Lepr Other Mycobact Dis VL - 59 IS - 2 N2 - A male born in 1930 was diagnosed as smear-positive borderline leprosy in 1971, and was treated with dapsone and/or sulfamethoxypyridazine from 1972 to 1980 with clinical improvement. However, new skin lesions with smears strongly positive appeared in August 1980, and he was diagnosed as having downgraded to lepromatous (LL) leprosy, but the bacilli recovered from the skin biopsy were fully susceptible to both dapsone and rifampin by mouse foot pad technique. Between 1981 and 1983, the patient was treated with 24 months of rifampin 600 mg and dapsone 100 mg daily, supplemented with prothionamide 500 mg daily during the initial 3 months, and his skin lesions gradually improved during treatment with the combined regimen. Afterward, the patient was kept under surveillance without treatment. From 1984 to 1986, his skin smears were negative, and no bacilli could be found from a skin biopsy taken in 1985. Then in 1987, 52 months after stopping treatment, new skin lesions appeared with a high concentration of Mycobacterium leprae (2 x 10(6)/mg tissue). The drug-susceptibility test again demonstrated that the organisms were fully susceptible to both dapsone and rifampin. Apparently the relapse was due to remultiplication of drug-susceptible persisters. SN - 0148-916X UR - https://www.unboundmedicine.com/medline/citation/2071981/A_case_of_relapse_with_drug_susceptible_M__leprae_after_multidrug_therapy_ DB - PRIME DP - Unbound Medicine ER -