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MC4R variant is associated with BMI but not response to resistance training in young females.
Obesity (Silver Spring) 2011; 19(3):662-6O

Abstract

Recently, a genome-wide association study (GWAS) that identified eight single-nucleotide polymorphisms (SNPs) associated with BMI highlighted a possible neuronal influence on the development of obesity. We hypothesized these SNPs would govern the response of BMI and subcutaneous fat to resistance training in young individuals (age = 24 years). We genotyped the eight GWAS-identified SNPs in the article by Willer et al. in a cohort (n = 796) that undertook a 12-week resistance-training program. Females with a copy of the rare allele (C) for rs17782313 (MC4R) had significantly higher BMIs (

CC/CT

n = 174; 24.70 ± 0.33 kg/m², TT: n = 278; 23.41 ± 0.26 kg/m², P = 0.002), and the SNP explained 1.9% of overall variation in BMI. Males with a copy of the rare allele (T) for rs6548238 (TMEM18) had lower amounts of subcutaneous fat pretraining (CT/TT: n = 65; 156,534 ± 7,415 mm³, CC: n = 136; 177,825 ± 5,139 mm³, P = 0.019) and males with a copy of the rare allele (A) for rs9939609 (FTO) lost a significant amount of subcutaneous fat with exercise (

AT/AA

n = 83; -798.35 ± 2,624.30 mm³, TT: n = 47; 9,435.23 ± 3,494.44 mm³, P = 0.021). Females with a copy of the G allele for a missense variant in the SH2B1 (rs7498665) was associated with less change of subcutaneous fat volume with exercise (

AG/GG

n = 191; 9,813 ± 2,250 mm³ vs. AA: n = 126; 770 ± 2,772 mm³; P = 0.011). These data support the original finding that there is an association between measures of obesity and a variant near the MC4R gene and extends these results to a younger population and implicates FTO, TMEM18, and SH2B1 polymorphisms in subcutaneous fat regulation.

Authors+Show Affiliations

Research Center for Genetic Medicine, Children's National Medical Center, Washington, DC, USA. fsuer@cnmcresearch.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

20725061

Citation

Orkunoglu-Suer, Funda E., et al. "MC4R Variant Is Associated With BMI but Not Response to Resistance Training in Young Females." Obesity (Silver Spring, Md.), vol. 19, no. 3, 2011, pp. 662-6.
Orkunoglu-Suer FE, Harmon BT, Gordish-Dressman H, et al. MC4R variant is associated with BMI but not response to resistance training in young females. Obesity (Silver Spring). 2011;19(3):662-6.
Orkunoglu-Suer, F. E., Harmon, B. T., Gordish-Dressman, H., Clarkson, P. M., Thompson, P. D., Angelopoulos, T. J., ... Devaney, J. M. (2011). MC4R variant is associated with BMI but not response to resistance training in young females. Obesity (Silver Spring, Md.), 19(3), pp. 662-6. doi:10.1038/oby.2010.180.
Orkunoglu-Suer FE, et al. MC4R Variant Is Associated With BMI but Not Response to Resistance Training in Young Females. Obesity (Silver Spring). 2011;19(3):662-6. PubMed PMID: 20725061.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - MC4R variant is associated with BMI but not response to resistance training in young females. AU - Orkunoglu-Suer,Funda E, AU - Harmon,Brennan T, AU - Gordish-Dressman,Heather, AU - Clarkson,Priscilla M, AU - Thompson,Paul D, AU - Angelopoulos,Theodore J, AU - Gordon,Paul M, AU - Hubal,Monica J, AU - Moyna,Niall M, AU - Pescatello,Linda S, AU - Visich,Paul S, AU - Zoeller,Robert F, AU - Hoffman,Eric P, AU - Devaney,Joseph M, Y1 - 2010/08/19/ PY - 2010/8/21/entrez PY - 2010/8/21/pubmed PY - 2011/10/5/medline SP - 662 EP - 6 JF - Obesity (Silver Spring, Md.) JO - Obesity (Silver Spring) VL - 19 IS - 3 N2 - UNLABELLED: Recently, a genome-wide association study (GWAS) that identified eight single-nucleotide polymorphisms (SNPs) associated with BMI highlighted a possible neuronal influence on the development of obesity. We hypothesized these SNPs would govern the response of BMI and subcutaneous fat to resistance training in young individuals (age = 24 years). We genotyped the eight GWAS-identified SNPs in the article by Willer et al. in a cohort (n = 796) that undertook a 12-week resistance-training program. Females with a copy of the rare allele (C) for rs17782313 (MC4R) had significantly higher BMIs ( CC/CT: n = 174; 24.70 ± 0.33 kg/m², TT: n = 278; 23.41 ± 0.26 kg/m², P = 0.002), and the SNP explained 1.9% of overall variation in BMI. Males with a copy of the rare allele (T) for rs6548238 (TMEM18) had lower amounts of subcutaneous fat pretraining (CT/TT: n = 65; 156,534 ± 7,415 mm³, CC: n = 136; 177,825 ± 5,139 mm³, P = 0.019) and males with a copy of the rare allele (A) for rs9939609 (FTO) lost a significant amount of subcutaneous fat with exercise ( AT/AA: n = 83; -798.35 ± 2,624.30 mm³, TT: n = 47; 9,435.23 ± 3,494.44 mm³, P = 0.021). Females with a copy of the G allele for a missense variant in the SH2B1 (rs7498665) was associated with less change of subcutaneous fat volume with exercise ( AG/GG: n = 191; 9,813 ± 2,250 mm³ vs. AA: n = 126; 770 ± 2,772 mm³; P = 0.011). These data support the original finding that there is an association between measures of obesity and a variant near the MC4R gene and extends these results to a younger population and implicates FTO, TMEM18, and SH2B1 polymorphisms in subcutaneous fat regulation. SN - 1930-739X UR - https://www.unboundmedicine.com/medline/citation/20725061/MC4R_variant_is_associated_with_BMI_but_not_response_to_resistance_training_in_young_females_ L2 - https://doi.org/10.1038/oby.2010.180 DB - PRIME DP - Unbound Medicine ER -