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Bone mineral density, vitamin D, and disease activity in children newly diagnosed with inflammatory bowel disease.
Dig Dis Sci. 2011 Mar; 56(3):825-9.DD

Abstract

BACKGROUND AND AIM

The aim of this study was to examine bone mineral density and serum 25-hydroxy vitamin D in relation to disease activity in children newly diagnosed with IBD.

METHODS

In a cross-sectional analytic study, 60 children newly diagnosed with IBD (39 with Crohn's disease [CD], mean age 12.2 ± 2.1 years; and 21 with ulcerative colitis [UC], mean age 12.4 ± 3.7 years) were recruited. Fifty-six age- and sex-matched children without IBD were invited as controls (mean age 11.3 ± 4.2 years). Serum 25-hydroxy vitamin D for patients and controls was measured at diagnosis. Patients' adjusted lumbar spine bone mineral density (BMD) z scores were measured. Activity indices for both CD and UC were calculated.

RESULTS

The serum level of 25-hydroxy vitamin D was significantly lower in children with IBD compared to the control group (P = 0.04). BMD was significantly lower in patients with CD compared to those with UC (P = 0.039). There was no correlation between vitamin D levels, BMD z scores or disease activity indices for both CD and UC.

CONCLUSIONS

Serum vitamin D level is significantly lower in children with newly diagnosed IBD compared to those without. However, vitamin D levels are not affected by disease severity. It seems that BMD status may not be affected by vitamin D levels or disease severity in this cohort. Larger prospective controlled studies are needed to confirm these findings.

Authors+Show Affiliations

Division of Pediatric Gastroenterology, Alder Hey Children's NHS Foundation Trust, Eaton Road, Liverpool, L12 2AP, UK. wael.el-matary@alderhey.nhs.ukNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20725784

Citation

El-Matary, Wael, et al. "Bone Mineral Density, Vitamin D, and Disease Activity in Children Newly Diagnosed With Inflammatory Bowel Disease." Digestive Diseases and Sciences, vol. 56, no. 3, 2011, pp. 825-9.
El-Matary W, Sikora S, Spady D. Bone mineral density, vitamin D, and disease activity in children newly diagnosed with inflammatory bowel disease. Dig Dis Sci. 2011;56(3):825-9.
El-Matary, W., Sikora, S., & Spady, D. (2011). Bone mineral density, vitamin D, and disease activity in children newly diagnosed with inflammatory bowel disease. Digestive Diseases and Sciences, 56(3), 825-9. https://doi.org/10.1007/s10620-010-1380-5
El-Matary W, Sikora S, Spady D. Bone Mineral Density, Vitamin D, and Disease Activity in Children Newly Diagnosed With Inflammatory Bowel Disease. Dig Dis Sci. 2011;56(3):825-9. PubMed PMID: 20725784.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bone mineral density, vitamin D, and disease activity in children newly diagnosed with inflammatory bowel disease. AU - El-Matary,Wael, AU - Sikora,Sheena, AU - Spady,Donald, Y1 - 2010/08/20/ PY - 2010/04/23/received PY - 2010/07/29/accepted PY - 2010/8/21/entrez PY - 2010/8/21/pubmed PY - 2011/4/28/medline SP - 825 EP - 9 JF - Digestive diseases and sciences JO - Dig Dis Sci VL - 56 IS - 3 N2 - BACKGROUND AND AIM: The aim of this study was to examine bone mineral density and serum 25-hydroxy vitamin D in relation to disease activity in children newly diagnosed with IBD. METHODS: In a cross-sectional analytic study, 60 children newly diagnosed with IBD (39 with Crohn's disease [CD], mean age 12.2 ± 2.1 years; and 21 with ulcerative colitis [UC], mean age 12.4 ± 3.7 years) were recruited. Fifty-six age- and sex-matched children without IBD were invited as controls (mean age 11.3 ± 4.2 years). Serum 25-hydroxy vitamin D for patients and controls was measured at diagnosis. Patients' adjusted lumbar spine bone mineral density (BMD) z scores were measured. Activity indices for both CD and UC were calculated. RESULTS: The serum level of 25-hydroxy vitamin D was significantly lower in children with IBD compared to the control group (P = 0.04). BMD was significantly lower in patients with CD compared to those with UC (P = 0.039). There was no correlation between vitamin D levels, BMD z scores or disease activity indices for both CD and UC. CONCLUSIONS: Serum vitamin D level is significantly lower in children with newly diagnosed IBD compared to those without. However, vitamin D levels are not affected by disease severity. It seems that BMD status may not be affected by vitamin D levels or disease severity in this cohort. Larger prospective controlled studies are needed to confirm these findings. SN - 1573-2568 UR - https://www.unboundmedicine.com/medline/citation/20725784/Bone_mineral_density_vitamin_D_and_disease_activity_in_children_newly_diagnosed_with_inflammatory_bowel_disease_ L2 - https://doi.org/10.1007/s10620-010-1380-5 DB - PRIME DP - Unbound Medicine ER -