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Molecular interaction fields and 3D-QSAR studies of p53-MDM2 inhibitors suggest additional features of ligand-target interaction.
J Chem Inf Model. 2010 Aug 23; 50(8):1451-65.JC

Abstract

The design and optimization of small molecule inhibitors of the murine double minute clone 2-p53 (p53-MDM2) interaction has attracted a great deal of interest as a way to novel anticancer therapies. Herein we report 3D-QSAR studies of 41 small molecule inhibitors based on the use of molecular interaction fields and docking experiments as part of an approach to generating predictive models of MDM2 affinity and shedding further light on the structural elements of the ligand-target interaction. These studies have yielded predictive models explaining much of the variance of the 41 compound training set and satisfactorily predicting with 75% success an external test set of 36 compounds. Not surprisingly, and in full agreement with previous data, inspection of the 3D-QSAR coefficients reveals that the major driving force for potent inhibition is given by the hydrophobic interaction between the inhibitors and the p53 binding cleft of MDM2. More surprisingly, and challenging previous suggestions, the projection of the 3D-QSAR coefficients back onto the experimental structures of MDM2 provides an intriguing hypothesis concerning an active role played by the N-terminal region of MDM2 in ligand binding.

Authors+Show Affiliations

Dipartimento di Chimica e Tecnologia del Farmaco, Universita di Perugia, via del Liceo 1, 06123 Perugia, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20726601

Citation

Dezi, Cristina, et al. "Molecular Interaction Fields and 3D-QSAR Studies of p53-MDM2 Inhibitors Suggest Additional Features of Ligand-target Interaction." Journal of Chemical Information and Modeling, vol. 50, no. 8, 2010, pp. 1451-65.
Dezi C, Carotti A, Magnani M, et al. Molecular interaction fields and 3D-QSAR studies of p53-MDM2 inhibitors suggest additional features of ligand-target interaction. J Chem Inf Model. 2010;50(8):1451-65.
Dezi, C., Carotti, A., Magnani, M., Baroni, M., Padova, A., Cruciani, G., Macchiarulo, A., & Pellicciari, R. (2010). Molecular interaction fields and 3D-QSAR studies of p53-MDM2 inhibitors suggest additional features of ligand-target interaction. Journal of Chemical Information and Modeling, 50(8), 1451-65. https://doi.org/10.1021/ci100113p
Dezi C, et al. Molecular Interaction Fields and 3D-QSAR Studies of p53-MDM2 Inhibitors Suggest Additional Features of Ligand-target Interaction. J Chem Inf Model. 2010 Aug 23;50(8):1451-65. PubMed PMID: 20726601.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Molecular interaction fields and 3D-QSAR studies of p53-MDM2 inhibitors suggest additional features of ligand-target interaction. AU - Dezi,Cristina, AU - Carotti,Andrea, AU - Magnani,Matteo, AU - Baroni,Massimo, AU - Padova,Alessandro, AU - Cruciani,Gabriele, AU - Macchiarulo,Antonio, AU - Pellicciari,Roberto, PY - 2010/8/24/entrez PY - 2010/8/24/pubmed PY - 2010/12/21/medline SP - 1451 EP - 65 JF - Journal of chemical information and modeling JO - J Chem Inf Model VL - 50 IS - 8 N2 - The design and optimization of small molecule inhibitors of the murine double minute clone 2-p53 (p53-MDM2) interaction has attracted a great deal of interest as a way to novel anticancer therapies. Herein we report 3D-QSAR studies of 41 small molecule inhibitors based on the use of molecular interaction fields and docking experiments as part of an approach to generating predictive models of MDM2 affinity and shedding further light on the structural elements of the ligand-target interaction. These studies have yielded predictive models explaining much of the variance of the 41 compound training set and satisfactorily predicting with 75% success an external test set of 36 compounds. Not surprisingly, and in full agreement with previous data, inspection of the 3D-QSAR coefficients reveals that the major driving force for potent inhibition is given by the hydrophobic interaction between the inhibitors and the p53 binding cleft of MDM2. More surprisingly, and challenging previous suggestions, the projection of the 3D-QSAR coefficients back onto the experimental structures of MDM2 provides an intriguing hypothesis concerning an active role played by the N-terminal region of MDM2 in ligand binding. SN - 1549-960X UR - https://www.unboundmedicine.com/medline/citation/20726601/Molecular_interaction_fields_and_3D_QSAR_studies_of_p53_MDM2_inhibitors_suggest_additional_features_of_ligand_target_interaction_ L2 - https://doi.org/10.1021/ci100113p DB - PRIME DP - Unbound Medicine ER -